PERIODONTITIS

This study tests a new treatment for chronic gum disease (periodontitis) using stem cells from donated teeth. The stem cells are injected into the gums to help regrow tissue and bone, potentially avoiding the need for traditional surgery. The trial will include 30 adults with adv…

This pilot study tests whether a weekly diabetes medication (GLP-1RA) can improve gum health in people with both periodontitis and type 2 diabetes. Researchers will measure changes in gum pocket depth, bleeding, and tooth mobility in 30 adults. Results will help design a larger, …

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure (MINST) helps heal advanced gum disease better than deep cleaning alone. Twenty adults with severe gum disease will be randomly assigned to use either the active mouthwash or a plac…

This study looks at whether adding hyaluronic acid gel to standard deep-cleaning treatment helps gums heal better in smokers with advanced gum disease. Researchers will compare gum pockets treated with the gel plus cleaning versus cleaning alone in 23 participants. They will meas…

This study tests an experimental injection called LP-005 for people with moderate-to-severe gum disease (periodontitis). About 100 adults will receive either the drug or a placebo to see if it reduces gum inflammation, bleeding, and bone loss. The goal is to control the disease a…

This study tests a new mouthwash called Amphion in 60 adults with gum disease (periodontitis). Participants will use the mouthwash along with standard deep cleaning to see if it reduces plaque and gum bleeding better than cleaning alone. The mouthwash works by forming a physical …

This study tests if adding special gels (sodium hypochlorite/amino acid and cross-linked hyaluronic acid) to standard deep cleaning helps treat periodontitis, a serious gum infection. About 78 adults with deep gum pockets will receive one of three treatments and be checked after …

This study tests whether a toothpaste and powder made from tinder fungus can improve gum health in people with advanced gum disease (periodontitis). About 70 adults will use either the fungus-based products or a regular toothpaste alongside standard deep cleaning. The main goal i…

This study tests whether using a laser along with ultrasonic cleaning is as good as the standard manual plus ultrasonic cleaning for treating advanced gum disease. About 174 adults with severe periodontitis will receive one of the two treatments. The goal is to see if the laser m…

This study compares two types of gum dressings (Ora-Aid and Coe-Pak) placed after a deep cleaning procedure for people with moderate gum disease. Twenty-five adults with Stage 3 periodontitis will receive both dressings on different sides of their mouth to see which one reduces p…

This study will check if simple methods like mouth photos, smartphone images, X-rays, and questionnaires can accurately find gum disease compared to a standard dental exam. About 2,000 adults will take part across five centers. The goal is to develop AI tools that make screening …

This study aims to see if a self-reported questionnaire can accurately identify gum disease (periodontitis or gingivitis) in adults in Saudi Arabia. About 291 participants will fill out the questionnaire and then receive a standard dental exam on the same visit. The results will …

This study aims to validate an Italian version of a widely used gum disease screening questionnaire and develop an improved version with extra questions. Researchers will enroll 495 adults across 10 Italian centers to see how accurately the questionnaire identifies people with pe…

This study will test whether chewing xylitol-containing gum during pregnancy can reduce the risk of preterm birth and low birthweight. About 6,000 pregnant women in Malawi will be randomly assigned to chew gum with a high or low dose of xylitol, or a placebo gum. The goal is to s…

This study looks at whether people with multiple sclerosis (MS) have different gum health compared to those without MS. Researchers will measure gum disease signs, bacteria, and immune markers in saliva from 100 adults. The goal is to better understand how these two chronic infla…

This observational study looks at how gum disease (periodontitis) and chronic kidney disease might be connected. Researchers will study mouth and gut bacteria in 80 adults aged 18 to 75 to see if there is a link. The goal is to better understand the relationship, not to test a tr…

This study looks at how obesity is linked to oral health problems like gum disease and cavities. Researchers will follow 400 adults who are getting weight-loss treatment (diet or surgery) and check their mouth health over 18 months. The goal is to see if losing weight improves de…

This study looks at whether routine gum cleaning can improve heart health in people with stable angina. Researchers will measure certain blood markers before and three months after a standard dental cleaning. The goal is to understand the link between gum disease and heart diseas…

This study looks at whether eating a diet that causes inflammation can make gum disease worse in people with metabolic syndrome (a cluster of conditions like high blood sugar and belly fat). Researchers will track the diets and gum health of 100 adults to see if there's a link. T…

This study looks at how metabolic syndrome—a group of conditions like high blood pressure, high blood sugar, and extra belly fat—might make gum disease worse. Researchers will measure gum inflammation and tissue loss in 100 adults to see if a special score called PISA can help pr…

This study looks at whether teeth that bear more chewing force are more likely to have severe gum disease. Researchers will measure bite patterns in 50 adults with natural teeth or fixed dental work. The goal is to understand the link between chewing loads and gum health, which c…

This study will compare 88 people with oral lichen planus (a chronic mouth condition) to 88 healthy people to see if they have more gum disease. Participants will get standard dental exams. The goal is to understand if these two conditions are linked, which could help dentists pr…

This study aims to find out if tiny plastic particles, called microplastics, are present in the deep gum pockets of people with severe gum disease (periodontitis). Researchers will collect plaque samples from 25 adults with advanced gum disease who have not yet started treatment.…

This observational study will enroll 100 adults with chronic kidney disease to see if a diet that causes inflammation is linked to worse gum disease. Researchers will measure participants' gum health and calculate a dietary inflammation score from food records. The goal is to und…

This study looks at whether non-surgical gum treatment can change levels of asprosin, a protein linked to heart health, in 60 adults with both stable angina and gum disease. Participants will receive standard gum therapy, and their blood asprosin levels will be measured before an…

This study will check if the amount of plaque in a person's mouth can predict how well non-surgical gum treatment works. About 100 adults with gum disease will get standard deep cleaning, and their gum health will be checked at 3, 6, 9, and 12 months after. The goal is to see if …

This study looks at how common and severe gum disease is in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare them to people with chronic kidney disease and healthy volunteers. Participants ge…