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Coffee might boost gum Healing—A trial puts it to the test

NCT ID NCT07747545

Disease control Sponsor: Haoran Feng Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 19, 2026 · Updated 3 times

Summary

This trial asks whether daily caffeine intake can improve recovery after standard gum disease treatment. About 90 adults with periodontitis will receive non-surgical treatment and then be randomly assigned to avoid caffeine or consume low or moderate amounts for 6 months. Researchers will track gum health and measure inflammation and oral bacteria in saliva to see if caffeine makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dietary caffeine
What this could lead to
If caffeine helps, it could offer a simple dietary way to support gum recovery and reduce inflammation after periodontal treatment.
What could go wrong
This is a small, early-stage trial, and results may not apply to everyone. Caffeine can also cause side effects like jitteriness or sleep issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 55 years. * Diagnosed with periodontitis according to the 2018 Classification of Periodontal and Peri-Implant Diseases and Conditions. * First visit for periodontal treatment and eligible for standard non-surgical periodontal therapy. * Willing and able to comply with the dietary intervention and scheduled follow-up visits. * Able to understand the study procedures and provide written informed consent. * Able to communicate effectively and complete study questionnaires and follow-up assessments. Exclusion Criteria: * Pregnant or breastfeeding women, or women planning pregnancy during the study period. * History of periodontal treatment within the previous 6 months. * Current smokers or tobacco users. * Use of antibiotics, anti-inflammatory drugs, immunosuppressive agents, or medications known to affect periodontal status within the previous 3 months. * Presence of systemic diseases that may influence periodontal conditions, including diabetes mellitus, hypertension, or hyperlipidemia. * Severe systemic diseases, psychiatric disorders, or other conditions that may interfere with study participation or protocol compliance. * Allergy or intolerance to caffeine or inability to comply with the dietary caffeine intervention. * Individuals with limited hand function or other conditions preventing adequate oral hygiene practices.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Stomatological Hospital of Xuzhou Medical University

    Xuzhou, Jiangsu, 221000, China

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