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Could a simple mouthwash boost gum disease healing?

NCT ID NCT07203872

Disease control Sponsor: Guy's and St Thomas' NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for six months. Researchers will measure gum pocket depth, take saliva and blood samples, and track healing to see if the combination works better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2025

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 to 70 2. Diagnosis of periodontitis stage III-IV 3. Presence of at least 1 deep intrabony defect (both PPD and radiographic defects \>6mm) 4. Full-mouth dichotomous plaque score\>30% 5. Willing to voluntarily sign the informed consent. Exclusion Criteria: 1. Previous periodontal treatment to the study site within 6 months 2. Use of systemic antibiotics within 3 months 3. Weekly regular use of non-steroidal anti-inflammatory drugs 4. Contributing medical history according to the examining clinician (e.g. diabetes mellitus) 5. Smoking history (current or within 5 years) 6. Allergic to any ingredient present in the products used in study. 7. Presence of systemic diseases, which affects bone and/or connective tissue metabolism 8. Concurrent participation in other clinical studies. 9. Pregnant or breastfeeding.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal diseases Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Oral Clinical Research Unit (OCRU) at King's College London (KCL)

    London, SE1 9RT, United Kingdom

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