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Spit test could spot gum disease before It's too late

NCT ID NCT07254039

Diagnosis Sponsor: Ostergotland County Council, Sweden Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is developing a new, non-invasive saliva test that uses artificial intelligence to detect gum disease (periodontitis) early. Researchers will collect saliva from 200 adults—some with gum disease and some healthy—and analyze it with a special sensor. The goal is to see if the AI can accurately tell who has the disease, which could lead to quicker, easier diagnosis at the dentist's office.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AI-assisted electrochemical sensor platform
What this could lead to
If successful, this could lead to a simple, non-invasive saliva test for early gum disease detection, enabling faster treatment and preventing tooth loss.
What could go wrong
This is an early observational study with 200 people. The sensor may not be accurate enough in real-world settings, and AI models may not generalize well beyond this small sample.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult participants (≥18 years) will be recruited from an affiliated dental clinic. The study population consists of two groups: (1) patients clinically diagnosed with periodontitis according to the 2018 AAP/EFP classification, and (2) periodontally healthy adults with no signs of periodontal disease. All participants must be able to provide informed consent and a saliva sample according to study protocol.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adults ≥18 years. Able and willing to provide written informed consent. Ability to provide an unstimulated whole saliva sample per protocol (no food, drink, gum, toothbrushing, or smoking within 60 minutes prior to sampling). Periodontitis group: Clinical diagnosis of periodontitis according to 2018 AAP/EFP criteria (e.g., interdental CAL ≥3 mm at ≥2 non-adjacent teeth with radiographic bone loss; probing pocket depth ≥4 mm in ≥2 teeth). Healthy control group: No clinical signs of periodontal disease (no probing depths \>3 mm, bleeding on probing \<10%, and no radiographic bone loss). Exclusion Criteria: Systemic antibiotics or systemic anti-inflammatory/immunosuppressive therapy within the past 3 months. Periodontal therapy (scaling/root planing or surgery) within the past 6 months. Current acute oral infection or abscess. Systemic conditions known to markedly alter saliva composition/flow (e.g., Sjögren's syndrome, prior head-and-neck radiation, ongoing chemotherapy, uncontrolled diabetes). Use of strongly xerogenic medications not on a stable dose ≥4 weeks, or clinically significant hyposalivation preventing sampling. Inability to comply with sampling procedures (e.g., cannot abstain from food/drink/tobacco for 60 minutes prior to sampling). Pregnancy or lactation.

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Conditions

The condition(s) this trial relates to.

disease periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biomarkers (D23.050.301) Diagnostic Periodontal diseases SALIVA

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

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