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Gum disease may throw off the body's internal wiring — a heart-rhythm test puts the idea to the test

NCT ID NCT07735312

Knowledge-focused Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This study investigates whether chronic gum disease (periodontitis) is linked to changes in the autonomic nervous system — the body's automatic 'wiring' that controls heart rate, digestion, and stress responses. Researchers will measure heart rate variability, a marker of nervous system balance, in 50 adults with and without periodontitis. They will also check blood levels of inflammatory markers to see if any connection involves inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-surgical periodontal therapy (scaling and root planing)
What this could lead to
If a link is found, it could point toward better ways to monitor or manage the body-wide effects of gum disease.
What could go wrong
This is a small observational study, so it cannot prove cause and effect. Results may not apply to everyone with periodontitis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged between 35 and 50 years; * Presence of at least 15 teeth, excluding third molars and teeth indicated for extraction; * Individuals diagnosed with generalized stage III or IV, grade B or C periodontitis according to the 2017 Classification of Periodontal and Peri-Implant Diseases and Conditions; * At least 30% of teeth presenting probing depth and clinical attachment loss ≥ 5 mm with bleeding on probing; * Ability and willingness to provide written informed consent. Exclusion Criteria: * Completely edentulous individuals; * Individuals presenting fewer than 15 teeth; * Pregnant women; * Smokers; * Individuals diagnosed with type 1 or type 2 diabetes mellitus; * Individuals with chronic systemic diseases, including chronic arterial hypertension, class III or IV heart failure, or Parkinson's disease; * Individuals with pacemakers or atrial fibrillation/flutter; * Individuals who received periodontal treatment within the previous 12 months; * Individuals who used systemic antibiotics within the previous 6 months; * Individuals with contraindications to periodontal procedures; * Individuals requiring antibiotic prophylaxis before periodontal treatment; * Individuals with blood dyscrasias or anticoagulant conditions associated with increased bleeding risk.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac electrophysiology Periodontitis

Contacts and locations

Locations

  • FORP-USP

    Ribeirão Preto, São Paulo, 14.040-904, Brazil

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