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Could a deep clean for your gums also protect your heart?

NCT ID NCT07311512

Knowledge-focused Sponsor: Mahdi Mutahar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how standard gum disease treatments—deep cleaning with or without a special mouthwash—change proteins in your saliva and affect blood vessel health. Researchers will study 30 adults with gum disease to see if these treatments help or harm the good bacteria that support heart health. The goal is to understand how taking care of your gums might also protect your heart.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must have a minimum of 2 natural teeth in each sextant (at least 12 teeth overall). * Individuals with clinically diagnosed gingivitis and/or early periodontitis (stage 1 and 2) * Must not have undergone periodontal maintenance therapy (PMPR) within the last 6 months. * Must not currently be wearing orthodontic appliances, due to their effect on oral microbiota and plaque composition. * Must not be using removable orthodontic appliances, as they increase plaque accumulation. * Must not have taken any antibiotic treatments within the last 3 months. * Must be able to provide written informed consent. * Individuals with dental erosion or caries will still be included but matched during the baseline visit. Exclusion Criteria: * Individuals under regular medication within one month of the study start date for any medical condition (such as hypertension and/or diabetes) * Pregnant or breastfeeding individuals. * Individuals requiring an interpreter or who are non-English speakers. * Individuals unable to provide written informed consent. * Individuals participating in another ongoing clinical study (other than observational studies) within 3 months prior to or during this study. * Individuals who have used mouthwash or tongue scrapers in the last 6 weeks. * Individuals who consume 20 or more cigarettes per day. * Individuals who consume more than 5 alcoholic drinks per day.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder gingivitis periodontal disorder periodontitis vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardio vascular disease Endothelial function and arterial stiffness Oral-systemic link Periodontal disease (PD) Vascular dysfunction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Portsmouth

    RECRUITING

    Portsmouth, Hampshire, PO1 2QG, United Kingdom

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Other studies related to the condition(s) this trial covers.