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Saliva test may spot gum disease early, saving teeth

NCT ID NCT06576856

Diagnosis Sponsor: Midwestern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether certain proteins and metals in saliva can signal the start of gum disease before teeth are damaged. Researchers measured these markers in 106 adults with healthy gums or various stages of gum disease. The goal was to find a way to predict gum disease earlier, so dentists could step in sooner.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple saliva test that helps dentists catch gum disease early, before teeth are damaged.
What could go wrong
This was a small, observational study that only looked for patterns, not a treatment. The findings may not lead to a reliable test without much larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

106 people

The number who actually took part.

Started

Nov 2021

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The literature does not display a consistent number of estimate participants for reliable assessment of salivary markers; with correlate studies reporting to have included from 100 to 1000 participants. We aim to invite up to 200 subjects to participate in this research. Subjects will be allocated into four categories following the four stages of periodontitis from AAP classification, plus a fifth category as periodontal health individuals for control group. The results of this cohort will be analyzed to detect an effect size of 0.5 at the 0.05 significance level.

Ages

30 to 99 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * (1) 40 years of age or older with a healthy medical history and not meeting any of the exclusion criteria; * (2) requiring definitive periodontal treatment/routine care; and * (3) retaining a minimum of 20 teeth and without active carious lesions Exclusion Criteria: * 1\) with systemic illness affecting their immune system (i.e. diabetes, rheumatoid arthritis, etc); * (2) currently on chronic anti-inflammatory medications (i.e. steroids, TNFα-inhibitors, etc); and * (3) previously underwent active periodontal therapy within the past 2 years; * (4) who cannot read or speak English.

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Conditions

The condition(s) this trial relates to.

disease periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal disease, staging, salivary markers, diagnosis

Contacts and locations

Locations

  • Midwestern Univerity

    Downers Grove, Illinois, 60515, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.