Could a saliva test spot kidney trouble in diabetics?
NCT ID NCT07498894
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the link between gum disease and diabetes complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify simple saliva tests to detect gum disease or kidney complications earlier in people with diabetes.
- What could go wrong
- This is a small, completed observational study, not a treatment trial. The findings may not lead to any new tests or treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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126 people
The number who actually took part.
- Started
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Jun 2024
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Newly diagnosed type 2 diabetic subjects were recruited from patients diagnosed with type 2 diabetes for less than 5 years attending the outpatient clinic of the Department of Endocrinology, Pamukkale University Hospital and subsequently referred to the Department of Periodontology. Following periodontal examination, participants were diagnosed as periodontally healthy, gingivitis, or periodontitis, and were allocated to the corresponding study groups according to their periodontal status.
- Ages
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20 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Newly diagnosed diabetes: Diagnosed with type 2 diabetes mellitus for less than 5 years and the absence of any diabetic vascular complications * Diabetic nephropathy: Urinary albumin-to-creatinine ratio \>30 mg/g Exclusion Criteria: * Having fewer than 15 natural teeth * Pregnancy or lactation * History of malignancy * Use of systemic antibiotics or anti-inflammatory drugs within the 6 months prior to study enrollment * Periodontal treatment within the previous 6 months * Type 1 diabetes mellitus, gestational diabetes mellitus, or secondary diabetes mellitus
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Pamukkale University Faculty of Dentistry
Denizli, 20160, Turkey (Türkiye)
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