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Gum disease breakthrough? own blood may boost healing

NCT ID NCT07525531

Disease control Sponsor: Ondokuz Mayıs University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding platelet-rich fibrin (PRF) or injectable PRF, made from a patient's own blood, to standard deep cleaning can improve gum health in people with periodontitis. 56 participants received either standard treatment alone or with PRF/i-PRF added. Researchers measured gum pocket depth, attachment levels, and inflammation markers over 6 weeks to see if the blood-based treatments help gums heal better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich fibrin (PRF) and injectable platelet-rich fibrin (i-PRF) from the patient's own blood
What this could lead to
If it works, this could point toward a simple, natural way to boost gum healing after standard deep cleaning, potentially reducing the need for more invasive treatments.
What could go wrong
This is a small, early-stage study with only 56 participants, so results may not apply to everyone. The treatment is an add-on, not a standalone cure, and its long-term benefits are still unclear.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

56 people

The number who actually took part.

Started

Apr 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Voluntary consent to participate in the study * Individuals aged 18 years or older * Systemically healthy individuals * Abstaining from the use of any drugs for any purpose * No periodontal treatment history in the past six months * Individuals who do not smoke Exclusion Criteria: * Absence of willingness to engage in the studies * Individuals under the age of 18 * Existence of any systemic disease influencing periodontal condition and consistent medication usage * Administration of local or systemic antibiotics within the preceding six months * Chronicle of periodontal therapy during the past six months * History of any periodontal surgical intervention within the past 12 months * Pregnancy or lactation in female subjects * Teeth with endodontic lesion or mobility degrees 2 and 3

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

Contacts and locations

Locations

  • Ondokuz Mayıs University

    Samsun, Atakum, 55200, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.