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Could your gums predict Alzheimer's? new study investigates blood clues

NCT ID NCT07069244

Knowledge-focused Sponsor: Uskudar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study analyzed blood test results from 100 people over age 50 to see if there is a connection between gum inflammation and Alzheimer's disease. Researchers measured gum health and looked at various blood cell counts. The goal was to find blood markers that might link these two conditions, but the study only looked back at existing data, so it cannot prove that one causes the other.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify blood markers that link gum disease to Alzheimer's, potentially leading to earlier detection or risk assessment.
What could go wrong
This is a small, retrospective study that only looks at past data. It cannot prove cause and effect, and results may not apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Aug 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals with periodontitis with Alzheimer's disease (Case group), Individuals with periodontitis without Alzheimer's disease (Control group)

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between March 2022 and July 2025, those who applied to the Periodontics Departments of the Dentistry Faculties of Uskudar University, Bezmialem Vakif University and Bolu Abant Izzet Baysal University, * Informed consent form was obtained during the examination, * Over 50 years of age, * Non-smoker and non-alcoholic, * No psychiatric disorders affecting cognitive status and no medication affecting cognitive status, * Complete blood count was performed within the 6 months prior to the date of inclusion in the study, * No dental treatment within the last 1 year, * Periodontal examination was performed by expert periodontologists who calibrated the inter- and intra-examination, * Individuals diagnosed with periodontitis as a result of periodontal examination and radiographic examination, and * For individuals diagnosed with Alzheimer's disease: Recording their stage according to the Clinical Dementia Rating (CDR) and Standardized Mini-Mental Test (SMMT) scores Exclusion Criteria: * Individuals with fewer than 10 teeth, * Individuals with uncontrolled systemic disease, * Individuals who regularly use anti-inflammatories or corticosteroids

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Conditions

The condition(s) this trial relates to.

Alzheimer disease periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Biomarkers / blood Blood cell count Periodontal disease Periodontal inflammation Periodontitis

Contacts and locations

Locations

  • Bezmialem Vakif University

    Istanbul, Turkey (Türkiye)

  • Bolu Abant Izzet Baysal University

    Bolu, Turkey (Türkiye)

  • Uskudar University

    Istanbul, Turkey (Türkiye)

More trials for these conditions

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