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Sleep hormone gel boosts gum disease therapy?

NCT ID NCT07605767

Disease control Sponsor: Liaquat College of Medicine and Dentistry Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a melatonin gel applied to the gums can improve the results of standard deep-cleaning treatment for gum disease. Thirty adults with periodontitis received either the melatonin gel or a placebo gel alongside their regular dental cleaning. Researchers measured changes in gum pocket depth and attachment levels after three months to see if melatonin provided extra benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

30 people

The number who actually took part.

Started

Nov 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-45 years * Patients diagnosed with periodontitis with clinical attachment loss (CAL) between 3-4 mm * Systemically healthy individuals * Patients with controlled systemic diseases (ASA I \& II) * Patients willing to participate and provide informed consent Exclusion Criteria: * Smokers or tobacco users * Pregnant or lactating females * Patients with uncontrolled diabetes mellitus (HbA1c \>6.5%) * Patients who received periodontal therapy within the last 6 months * Patients who used antibiotics, anti-inflammatory drugs, sleeping pills, or antioxidant supplements within the last 6 months * Individuals working night shifts -Patients with mental illness or neuromuscular disorders- * Patients unwilling to participate or unable to comply with follow-up visits

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Melatonin Periodontal disease

Contacts and locations

Locations

  • Liaquat College of Medicine and Dentistry

    Karachi, Sindh, 7290, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.