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Gum disease breakthrough? own blood gel may boost healing

NCT ID NCT07363135

Disease control Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a gel made from patients' own blood, called albumin platelet-rich fibrin (Alb-PRF), can improve gum healing after deep cleaning for advanced gum disease. Twenty-three adults with Stage 3 periodontitis received the gel in deep gum pockets on one side of the mouth, while the other side got standard cleaning alone. Researchers measured gum pocket depth, attachment levels, and growth factors over 6 months to see if the gel leads to better tissue repair.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
albumin platelet-rich fibrin (Alb-PRF) gel
What this could lead to
If it works, this could lead to a better way to heal gums and bone after deep cleaning, reducing tooth loss from advanced gum disease.
What could go wrong
This is a small, early study with only 23 people, so results may not apply to everyone. The gel is experimental and may not improve healing over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23 people

The number who actually took part.

Started

Nov 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being diagnosed with Stage 3 Grade B periodontitis * Being between the ages of 18-65 * Vertical bone defects in two quadrants Exclusion Criteria: * Smoking * Having a systemic disease * Taking any medication * Being pregnant or breastfeeding * Having received chemotherapy, radiotherapy or immunosuppressant treatments * Having received periodontal treatment in the last 6 months•Having used antibiotics in the last 6 months

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Conditions

The condition(s) this trial relates to.

Camurati-Engelmann Syndrome periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis Periodontitis (stage 3)

Contacts and locations

Locations

  • Gulhane Faculty of Dentistry, University of Health Sciences, Ankara, Turkey

    Ankara, Keçiören, 06010, Turkey (Türkiye)

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