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Gum disease breakthrough? new gel boosts standard cleaning

NCT ID NCT06731777

Disease control Sponsor: Universidade Federal de Alfenas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a special oral gel called PHTALOX® could make standard deep-cleaning treatments for gum disease more effective. Forty-five adults with moderate to severe periodontitis received standard scaling and root planing, plus either the PHTALOX® gel, a chlorhexidine gel, or a placebo gel. The researchers measured gum pocket depth and attachment levels after 45 days to see if the new gel improved healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PHTALOX® (iron tetracarboxyphthalocyanine) oral gel
What this could lead to
If it works, this gel could become a simple, painless addition to standard dental cleanings to help control gum disease better.
What could go wrong
This is a small, early-stage trial with only 45 people and a short 45-day follow-up. The results may not apply to everyone, and the gel's long-term safety and effectiveness are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Jan 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with periodontitis stages II to IV (moderate to severe) grades A-C, with at least two non-adjacent interproximal sites showing probing depth (PD) ≥5 mm, clinical attachment level (CAL) ≥3 mm, and bleeding on probing Exclusion Criteria: * Medical conditions requiring antibiotic prophylaxis or that could influence the response to treatment. * History of periodontal treatment within the last 6 months. * Use of medications affecting periodontal tissues within the last 3 months (antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressants, or calcium channel blockers). * Smokers or former smokers within the last 12 months. * Pregnancy. * Extensive prosthetic rehabilitation. * Undergoing orthodontic treatment. * Individuals with blood dyscrasias. * Alcoholism. * Use of illicit drugs.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

Contacts and locations

Locations

  • Universidade Federal de Alfenas

    Alfenas, Minas Gerais, 37130-001, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.