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Gut and gums: does sleeve gastrectomy tame inflammation in the mouth?

NCT ID NCT07731412

Disease control Sponsor: George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This pilot study tests whether laparoscopic sleeve gastrectomy, a weight-loss surgery, can reduce markers of inflammation in saliva and improve gum health in adults with both obesity and periodontitis (gum disease). Participants are randomly assigned to either surgery or non-surgical weight management, and their gum condition and inflammatory markers are tracked for six months. The goal is to see if treating obesity through surgery might also help control gum inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
laparoscopic sleeve gastrectomy
What this could lead to
If this pilot shows promise, it could pave the way for a larger trial testing whether weight-loss surgery improves gum health and reduces inflammation in people with obesity.
What could go wrong
This is a small pilot study with only 32 participants, so results may not apply to everyone. Surgery carries risks, and any benefits for gum health may be modest or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

32 people

The number who actually took part.

Started

Dec 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 65 years. * Body mass index (BMI) ≥35 kg/m² with one or more obesity-related comorbidities, or BMI ≥40 kg/m². * Stage I-III periodontitis according to the 2018 periodontitis stage/grade classification. * At least 12 natural teeth in each dental arch. * Written informed consent provided before enrollment. Exclusion Criteria: * • Smoking more than 10 cigarettes per day. * Periodontal treatment within the previous 6 months. * Pregnancy or lactation. * Previous bariatric surgery. * Active autoimmune disorder, malignant disease, or another systemic disease known to markedly affect periodontal inflammation. * Recent antibiotic use * Recent systemic corticosteroid use * Regular non-steroidal anti-inflammatory drug use within 90 days before enrollment. * Current anti-obesity glucagon-like peptide-1 (GLP-1) therapy.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Periodontitis

Contacts and locations

Locations

  • George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures

    Târgu Mureş, 540136, Romania

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