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Your own blood may boost gum healing after surgery

NCT ID NCT07207668

Disease control Sponsor: Halil Ata BIÇAKÇIOGLU Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a gel made from patients' own blood (injectable platelet-rich fibrin, or i-PRF) could improve healing after standard gum surgery for periodontitis. 42 adults with deep gum pockets received surgery alone or surgery plus i-PRF and a root-cleaning gel. Researchers measured changes in pocket depth and gum attachment over 6 months. The goal was to see if this simple addition could lead to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Injectable platelet-rich fibrin (i-PRF) made from your own blood
What this could lead to
If it works, this could offer a simple, natural way to improve gum healing after standard surgery for periodontitis.
What could go wrong
This is a small, early study with only 42 people, so results may not apply to everyone. The treatment is an add-on to surgery, not a standalone cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

42 people

The number who actually took part.

Started

Feb 2023

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years and older * Diagnosis of Stage II-IV periodontitis * Presence of ≥3 adjacent teeth with probing pocket depth (PPD) ≥5 mm * Systemically healthy individuals * Non-smokers * Ability and willingness to comply with oral hygiene instructions and study follow-up visits Exclusion Criteria: * Systemic diseases or conditions affecting periodontal healing (e.g., uncontrolled diabetes, immunodeficiency) * Pregnancy or lactation * Current or previous smokers * Use of medications that may affect periodontal status (e.g., immunosuppressants, bisphosphonates) * Previous periodontal treatment within the last 6 months

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Conditions

The condition(s) this trial relates to.

chronic periodontitis Periodontal Pocket periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic periodontitis (disorder) Periodontitis

Contacts and locations

Locations

  • Gazi University Faculty of Dentistry, Department of Periodontology

    Ankara, 06590, Turkey (Türkiye)

More trials for these conditions

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