Gum disease breakthrough? hyaluronic acid gel may rival standard treatment
NCT ID NCT07230522
First seen Nov 17, 2025 · Last updated Jun 23, 2026 · Updated 32 times
Summary
This study tested whether a hyaluronic acid gel (HyaDent BG) works as well as Emdogain, a standard treatment, for repairing bone defects caused by gum disease. Both were used with a bone graft material during surgery. Seventeen adults with advanced periodontitis took part. The goal was to see if the hyaluronic acid could reduce pocket depth, improve gum attachment, and increase bone fill similarly to Emdogain.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Departement of Periodontology, Faculty of Dental Medicine, Medical University of Sofia
Sofia, Bulgaria
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyaluronic acid gel (HyaDent BG) and enamel matrix proteins (Emdogain)
What this could lead to
If hyaluronic acid works as well as Emdogain, it could offer a simpler, possibly cheaper option to help regrow bone lost to gum disease.
What could go wrong
This is a very small study (17 people) with no blinding, so results may not hold up in larger trials. Gum disease often requires ongoing care, so this is not a permanent fix.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.