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Gum disease chemical clue: adropin levels may reveal hidden inflammation

NCT ID NCT07695857

Knowledge-focused Sponsor: Giresun University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study measures levels of a substance called adropin in the gum fluid and blood of people with periodontitis (severe gum disease) and compares them to healthy gums. Researchers want to see if adropin changes after standard non-surgical gum treatment, and how it relates to a known inflammation marker, TNF-alfa. The goal is to better understand the body's response to gum disease and its treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nonsurgical periodontal therapy (scaling and root planing)
What this could lead to
If adropin levels change with treatment, it may point to a new marker for gum disease severity or healing.
What could go wrong
This is a small, early observational study. It only looks at chemical levels, not long-term health outcomes, and may not apply to smokers or people with other diseases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Apr 2018

Finished

Nov 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Criteria for healthy control group: BOP \< 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction. Criteria for periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.

Ages

27 to 49 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * having at least 20 natural teeth, excluding third molars * having no systemic disease * non-smokers * Diagnosed with periodontally health and periodontitis patients Exclusion Criteria: * having any systemic diseases * smoking * current pregnancy or lactation * a history of periodontal treatment in the past 6 months * using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

Contacts and locations

Locations

  • Giresun University

    Giresun, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.