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Zinc-Infused bone graft shows promise for rebuilding gums

NCT ID NCT07313254

Disease control Sponsor: Suez Canal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new combination treatment for gum disease-related bone loss. Thirty adults with deep gum pockets received a graft made from zinc-substituted nano-hydroxyapatite (a bone-like material) mixed with advanced platelet-rich fibrin (a blood-derived healing scaffold). The goal was to see if this approach improves gum health and bone regrowth better than standard surgery. Researchers measured gum inflammation, plaque, pocket depth, and attachment levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
zinc-substituted nano-hydroxyapatite bone graft combined with advanced platelet-rich fibrin block
What this could lead to
If successful, this could offer a better way to regenerate bone and gum tissue in people with advanced gum disease, potentially saving teeth that might otherwise be lost.
What could go wrong
This is a small, early study with only 30 participants, so results may not apply to everyone. The procedure is surgical and carries typical risks like infection or graft failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Jan 2023

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adequate oral hygiene conditions. 2. Age range from 20 years to 50 years. 3. All patients will be physically healthy. 4. Patients who are co-operatively motivated. Exclusion Criteria: 1. Those who smoke. 2. Women who are pregnant. 3. Patients with poorly controlled systemic diseases which preclude local anesthesia or surgical procedures.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal diseases Periodontitis

Contacts and locations

Locations

  • Eman Yehia

    Ismailia, Ismailia Governorate, 54321, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.