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Can new biomaterials regrow bone in advanced gum disease?

NCT ID NCT07738705

Disease control Sponsor: Lake Erie College of Osteopathic Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests different combinations of biomaterials used during gum surgery to treat class II furcation defects—areas where bone loss has occurred between the roots of molars. The goal is to see which combination best encourages bone regrowth and improves gum thickness. Adults with advanced periodontitis and at least one affected molar may participate. The study measures bone gain and gum changes using 3D imaging over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Surgical procedure using different biomaterial combinations (NovaBone, allograft, microderm or collagen membranes)
What this could lead to
If successful, this could identify a better biomaterial combination to regenerate bone and gum tissue in people with advanced gum disease, potentially improving tooth retention.
What could go wrong
This is a small, early-stage trial with 48 participants, so results may not apply broadly. Surgery carries risks like infection or poor healing, and the outcome depends on individual response.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

48 people

The number who actually took part.

Started

Apr 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Adults diagnosed with Stage III or Stage IV periodontitis presenting with at least one mandibular molar with a Class II furcation defect requiring regenerative surgical treatment. * Ability and willingness to provide written informed consent. * Medically stable and able to undergo periodontal surgery. * Willingness to comply with all study procedures and follow-up visits. Exclusion Criteria * Stage I or Stage II periodontitis. * Current smokers. * Uncontrolled diabetes mellitus. * Alcohol or substance use disorder. * Chronic inflammatory diseases requiring continuous anti-inflammatory therapy. * Current use of bisphosphonates or other medications associated with medication-related osteonecrosis of the jaw. * Current use of medications known to induce gingival enlargement. * Continuous use of systemic antibiotics or anti-inflammatory medications. * Pregnant or breastfeeding individuals. * Known allergy or hypersensitivity to the antibiotics, local anesthetics, or other study-related medications. * Medical conditions that, in the investigator's judgment, make the participant unsuitable for periodontal surgery or study participation.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal furcation lesions

Contacts and locations

Locations

  • LECOM School of Dental Medicine

    Bradenton, Florida, 34211, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.