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Laser light could boost gum disease treatment

NCT ID NCT07080762

Disease control Sponsor: Universita di Verona Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether adding a light-activated therapy, called antimicrobial photodynamic therapy (aPDT), to standard deep-cleaning for gum disease could kill more bacteria and improve gum health. Fifty adults with severe periodontitis received standard cleaning alone or with aPDT. The goal was to see if the combination leads to better bacterial reduction and shallower gum pockets.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antimicrobial photodynamic therapy (aPDT) using a photosensitizer and laser light
What this could lead to
If it works, this could offer a simple, non-invasive way to boost the effectiveness of standard gum disease treatment, potentially leading to better long-term gum health.
What could go wrong
This is a small, completed study with only 50 participants, so results may not apply to everyone. The added benefit of aPDT over standard care alone may be modest or not clinically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Jan 2024

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 84 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 84 years; * Good general health status; * Diagnosis of severe periodontitis involving at least 30% of all teeth, with at least three non-adjacent teeth presenting three sites with probing pocket depth (PPD) greater than 4 mm in at least two quadrants, and having lost at least four teeth due to periodontitis; * Presence of at least 16 teeth, with a minimum of four teeth per quadrant. Exclusion Criteria: * Pregnancy or breastfeeding; * Presence of decompensated systemic diseases that may compromise the outcomes of the study or the patient's health; * Regular use of antibiotics; * Regular use of anti-inflammatory drugs (NSAIDs, corticosteroids, or aspirin); * Use of anticoagulant medications; * History of systemic antibiotic therapy within six months prior to enrollment; * History of any periodontal therapy within six months prior to enrollment; * Presence of severe mental or cognitive disorders.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antimicrobial photodynamic therapy Periodontitis Photodynamic therapy (PDT)

Contacts and locations

Locations

  • Alessia Verona

    Verona, VR, 37134, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.