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Gum disease study probes hidden links to oxygen and metabolism

NCT ID NCT07182448

Knowledge-focused Sponsor: Istanbul Medipol University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study looked at how low oxygen levels and a metabolic pathway called the kynurenine pathway are involved in gum inflammation (periodontitis). Researchers collected blood and saliva from 45 healthy adults with either periodontitis or healthy gums. They measured markers of inflammation, oxygen response, and oxidative stress to better understand the disease process.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

45 people

The number who actually took part.

Started

Feb 2023

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Periodontally healthy and stage 3 garde B periodontitis patients were enrolled in this study

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * systemically healthy * clinical diagnosis of periodontitis * clinical diagnosis of periodontal health Exclusion Criteria: * decline to participate and being under 18 \&amp; over 65 years of age; * having any systemic inflammatory diseases such as diabetes, rheumatoid arthritis, or systemic conditions, including immunodeficiency syndrome, cardiovascular disorders, or hepatic disorders; * the use of antibiotics and/or anti-inflammatory nonsteroidal anti-inflammatory drugs within 3 months preceding the study; * having nonsurgical periodontal treatment (previous 6 months); * having surgical periodontal treatment (previous 12 months); * having \<20 natural teeth excluding the third molars.

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Conditions

The condition(s) this trial relates to.

Hypoxia periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diagnose disease Periodontitis

Contacts and locations

Locations

  • Istanbul Medipol University

    Istanbul, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.