New combo treatment offers hope for sensitive teeth after gum therapy

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. No reported or clinically detected dentin hypersensitivity prior to the initiation of non-surgical periodontal therapy. 2\. Presence of at least five teeth with probing pocket depths (PPD) ≥6 mm. 3. Systemically healthy individuals with no history of systemic diseases that may interfere with periodontal outcomes. 4\. Absence of deep restorations or visible cracks in the teeth adjacent to those selected for hypersensitivity evaluation. 5\. No previous treatment for dentin hypersensitivity and no current use of desensitizing toothpaste or products. 6\. Clinical diagnosis of Stage III or IV periodontitis, involving periodontal support loss in more than 30% of teeth. 7\. A clinical attachment level (CAL) ≥5 mm and radiographic evidence of bone loss extending to the mid-root level. 8\. Age 18 years or older at the time of enrollment Exclusion Criteria: * 1\. Use of antibiotics or analgesic medications at the time of screening or during the course of the study. 2\. Pregnancy or breastfeeding. 3. Receipt of periodontal therapy within the preceding 6 months. 4. Smoking history of 10 or more cigarettes per day. 5. Regular use of desensitizing toothpaste or other anti-hypersensitivity agents. 6\. Presence of parafunctional oral habits (e.g., bruxism, clenching). 7. Existence of non-carious cervical lesions such as erosion, attrition, or abrasion on study or adjacent teeth. 8\. High frequency of acidic dietary intake. 9. Inability to meet hypersensitivity perception thresholds following non-surgical periodontal therapy, defined as a Visual Analog Scale (VAS) score \>4 and Schiff Cold Air Sensitivity Scale score of 2 or 3. 10\. Contraindications to the use of Er,Cr:YSGG laser therapy, including but not limited to: known allergies to local or topical anesthetics, presence of cardiac devices (e.g., pacemakers or implantable defibrillators), respiratory disease, bleeding disorders, or immunosuppressive conditions. In such cases, written clearance from a physician is required. 11\. Known or suspected allergy to any component of the Gluma Desensitizer, specifically hydroxymethyl methacrylate or glutaraldehyde.