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Gum disease study reveals hidden inflammation clues in dental fluid

NCT ID NCT07503041

Knowledge-focused Sponsor: Oral Health Centre of Expertise in Western Norway Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examined fluid from deep gum pockets in 30 people with severe periodontitis, both smokers and non-smokers. Researchers measured 40 inflammatory markers before and after non-surgical deep cleaning. The goal was to see which markers change with treatment and whether smokers respond differently, helping to better understand gum disease and its management.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-surgical periodontal therapy (deep cleaning and plaque removal)
What this could lead to
If successful, this could help identify which inflammatory markers best predict gum disease severity and treatment success, potentially guiding more personalized care.
What could go wrong
This is a small, completed observational study with only 30 participants. The findings may not apply to broader populations, and the biomarkers identified may not prove useful in routine practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Jan 2016

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with severe periodontitis referred to our specialist clinic

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: healthy - Exclusion Criteria: pregnant, autoimmune disease, antibiotic use last 3 months \-

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Conditions

The condition(s) this trial relates to.

chronic periodontitis Inflammation Periodontal Pocket periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis Periodontitis chronic generalized severe

Contacts and locations

Locations

  • Postboks 2354 Møllendal

    Bergen, 5867, Norway

More trials for these conditions

Other studies related to the condition(s) this trial covers.