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Gum surgery upgrade: enamel proteins and bone graft show promise

NCT ID NCT07119307

Disease control Sponsor: Rungta College of Dental Sciences and Research Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This completed study tested a surgical technique called Entire Papilla Preservation (EPPT) alone or with added enamel matrix derivative and bone graft for repairing bone defects from gum disease. Fifty-eight adults with moderate to severe periodontitis took part. The goal was to see if adding these materials improves gum attachment and reduces pocket depth better than surgery alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
enamel matrix derivative and bone mineral derived xenograft
What this could lead to
If successful, this could improve surgical outcomes for repairing bone damage caused by gum disease, potentially saving teeth.
What could go wrong
This is a small, completed Phase 4 trial with 58 participants, so results may not apply to everyone. The procedure is surgical and carries typical risks like infection or gum recession.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

58 people

The number who actually took part.

Started

May 2023

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * stage II or III periodontitis, according to WWP 2017 classification of periodontal diseases in need of periodontal regenerative treatment for isolated intrabony defects * single-rooted teeth/multi-rooted teeth without furcation involvement Exclusion Criteria: * uncontrolled or poorly controlled diabetes, * unstable or life-threatening conditions, or requiring antibiotic prophylaxis, * History of use of medications since last 6 months (immunosuppressants and antibiotics), * Subjects allergic to medications, * Pregnant or lactating women, Smokers/users of other tobacco products, * Subjects showing unacceptable oral hygiene maintenance after initial phase I therapy and * multiple interconnected vertical defects.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intrabony periodontal defect Periodontal diseases

Contacts and locations

Locations

  • Rungta College of Dental Sciences and Research

    Bhilai, Chhattisgarh, 490024, India

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