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Gum surgery combo shows promise for regrowing bone in periodontitis patients

NCT ID NCT07233733

Disease control Sponsor: Phạm Đình Thiên Khải Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a gum surgery that combines a connective tissue graft with a special protein gel (enamel matrix derivative) to help regrow bone and gum tissue in people with advanced gum disease. Seventeen adults with deep gum pockets received the treatment, and researchers measured improvements in bone fill, gum attachment, and tissue stability over six months. The goal was to see if this approach leads to better healing and gum appearance compared to the patient's starting condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

17 people

The number who actually took part.

Started

Jun 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥18 years old who can provide written informed consent. * Diagnosis of stage III-IV periodontitis (2017 World Workshop). * Completed initial non-surgical periodontal therapy with good plaque control. * Full-mouth plaque score (FMPS) ≤20% and full-mouth bleeding score (FMBS) ≤20%. * Presence of ≥1 intrabony periodontal defect with an intrabony component ≥3 mm, confirmed clinically and radiographically. * Probing pocket depth (PPD) at the study site ≥6 mm. Exclusion Criteria: * Systemic conditions or medications that could affect periodontal healing (e.g., diabetes mellitus, immunodeficiency, bisphosphonates, corticosteroids, immunosuppressants). * Current smokers or former heavy smokers. * Pregnancy or lactation. * Teeth with untreated endodontic lesions or non-vital status; furcation involvement class II-III. * Untreated occlusal trauma or tooth mobility grade II-III. * Third molars.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal diseases Regeneration

Contacts and locations

Locations

  • University of Medicine and Pharmacy at Ho Chi Minh City - Faculty of Odonto-Stomatology

    Ho Chi Minh City, Ho Chi Minh City, 700000, Vietnam

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