Otorhinolaryngologic disease

This phase 2 trial is testing whether robotic surgery alone can control HPV-related throat cancer, potentially sparing patients the long-term side effects of chemotherapy and radiation. The study enrolls people with HPV-positive oropharyngeal cancer whose tumors are removable and…

This study tests whether the Butantan-Dengue vaccine is safe and works well in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable on low or no immune-suppressing drugs. Participants receive one vaccine dose and are monitored f…

This study tests a new whole-cell pneumococcal vaccine (wSp) in healthy children aged around 7 to 9 months who already received standard pneumonia vaccines. The goal is to see if wSp reduces pneumococcal bacteria in the nose and boosts immune protection. Researchers will compare …

This phase 2 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can shrink advanced squamous cell cancers of the nasal cavity and sinuses better than chemotherapy alone. About 35 adults with newly diagnosed, untreated stage II to IVb disease …

This phase II trial is testing whether the combination of cabozantinib (a targeted therapy) and nivolumab (an immunotherapy) can shrink or stabilize advanced melanoma and head and neck cancers that have stopped responding to prior immunotherapy. Researchers are also checking if t…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This trial tests whether fospropofol disodium, a newer form of propofol, can improve the surgical field quality during endoscopic sinus surgery compared to standard propofol anesthesia. The study includes adults aged 18-65 with chronic rhinosinusitis who are scheduled for sinus s…

This phase III trial tests whether adding the immunotherapy drug serplulimab to standard induction chemotherapy can allow patients with advanced nasopharyngeal cancer to skip concurrent chemotherapy during radiation. The study plans to enroll 456 adults aged 18-65 with stage II-I…

This phase II trial tests whether adding the immunotherapy drug relatlimab to standard nivolumab maintenance therapy can extend the time before cancer grows or spreads in patients with recurrent or metastatic nasopharyngeal cancer linked to Epstein-Barr virus. Participants first …

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Normally, some patients also get radiation afterward to lower the risk of cancer coming back. This trial tests whether it's safe to skip that radiation if a blood test two weeks after su…

This early-phase study tests whether adding the experimental drug ipatasertib to standard chemotherapy and radiation is safe and effective for people with advanced head and neck cancer. Ipatasertib may help stop cancer cell growth. About 46 participants will receive the combinati…

This study compares two treatments after surgery for stage III-IVA head and neck cancer: radiation alone versus radiation plus the chemotherapy drug cisplatin. The goal is to see which approach better prevents the cancer from returning, especially in patients with certain TP53 ge…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy (gemcitabine and cisplatin) before radiation therapy is safe and effective for children and young adults (up to age 21) with newly diagnosed nasopharyngeal carcinoma. The goal is to see if t…

This study tests a new handheld device called CLiKX that helps doctors place ear tubes in children and adults with chronic ear infections or fluid buildup. The device uses sensors and controlled force to make the procedure more precise. Researchers will check if the tube is place…

This phase II trial is testing whether adding chemotherapy or chemo-immunotherapy before standard salvage surgery can improve outcomes for patients with PD-L1 positive head and neck cancer that has come back. About 180 participants will receive either carboplatin and paclitaxel, …

This phase 2 trial tests whether pravastatin (a cholesterol drug) or a combination of pentoxifylline and vitamin E can prevent lymphedema and fibrosis (swelling and scarring) caused by radiation therapy in head and neck cancer patients. About 295 adults with oropharyngeal cancer …

This study tests whether adding cetuximab to standard immunotherapy (pembrolizumab) helps people with advanced head and neck cancer that has stopped responding to platinum chemotherapy live longer. About 158 adults with cancer that has returned or spread will receive either pembr…

This study looks at the best way to treat people with p53-mutant oral dysplasia (abnormal cells in the mouth) and early-stage oral cancer. About 636 adults will be placed into three groups based on their diagnosis and receive either monitoring, surgery, or surgery plus neck disse…

This study tests whether adding an experimental drug (CDX-1140) to a standard immunotherapy (cemiplimab) before surgery can shrink advanced head and neck cancers more than the immunotherapy alone. About 44 people with stage III-IV head and neck cancer will receive either the comb…

This study tests whether the biologic drug depemokimab, given as a shot, can shrink nasal polyps in Japanese adults with chronic sinusitis and nasal polyps who have not been helped by standard treatments. Participants receive depemokimab without using steroid nasal sprays. The ma…

This study tests a new drug called AVZO-1418 in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if it shrinks tumors. About 480 adults will take part, receiving the drug alone or with other treatments.

This early-stage study tests an experimental drug called IMGS-001 in about 105 people with advanced solid tumors that have come back or not improved after standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. The study has two parts: first, t…

This early-phase trial is testing whether a drug called camonsertib, combined with a precise type of radiation, can help control head and neck cancers that have come back or cannot be removed by surgery. About 39 adults with these cancers will receive the drug along with focused …

This early-phase trial is testing a new approach for people with head and neck cancer that has returned or spread after standard chemotherapy. The treatment combines a gene therapy injection (EDS01) given directly into a tumor with an immunotherapy drug (toripalimab) given throug…

This early-phase trial tests whether adding mild heat therapy (thermotherapy) to standard chemoradiation is safe and tolerable for people with advanced head and neck cancer. The heat, applied once a week, aims to make the cancer more sensitive to treatment. The study includes two…

This trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can help people with sinonasal cancer, a rare cancer of the nasal cavity and sinuses. Participants receive toripalimab along with carboplatin and docetaxel, then undergo sur…

This Phase 3 trial tests whether combining two drugs, MRG003 and pucotenlimab, works better than standard chemotherapy for people with nasopharyngeal cancer that has returned or spread. About 446 participants will be randomly assigned to receive either the new combo or one of thr…

This phase 3 trial is testing whether giving radiation only when needed (salvage therapy) works as well as giving it right away after immunotherapy and chemotherapy in people with nasopharyngeal cancer that has spread. The goal is to see if delaying radiation can reduce side effe…

This phase II trial tests whether a personalized, reduced-volume radiation plan can safely lower side effects after surgery for head and neck cancer. About 50 patients will receive radiation only to high-risk areas, skipping some traditionally treated zones. The goal is to see if…

This trial tests whether proton therapy causes fewer side effects than standard photon radiation in people with early tonsil cancer. About 100 patients will be randomly assigned to receive one of the two radiation types, both aimed at curing the cancer. Researchers will track acu…

This trial tests whether a daily probiotic pill can improve gut health and lower heart disease risk in 250 people living with HIV who drink heavily. Heavy drinking changes gut bacteria, which may raise inflammation and heart disease risk. Researchers will measure changes in gut b…

This trial is testing whether an experimental DNA vaccine called VB10.16, when combined with the standard immunotherapy drug pembrolizumab, can help people with a type of head and neck cancer linked to HPV16. The study includes adults with recurrent or metastatic cancer in the or…

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study follows 200 adults with severe chronic sinusitis and nasal polyps who are starting tezepelumab as part of their routine care. Researchers will track changes in symptoms and quality of life over up to two years using patient questionnaires. The goal is to see how well t…

This phase III trial compares a new, shorter radiation approach to the standard 7-week chemoradiation for patients with HPV-positive oropharynx cancer. The experimental treatment uses a precise, high-dose radiation boost to the tumor followed by a reduced-dose chemoradiation cour…

This phase II trial is testing whether combining becotatug vedotin with a PD-1 inhibitor can help people with recurrent nasopharyngeal carcinoma (a type of throat cancer). Participants will receive the drug combination for three cycles, then be evaluated for surgery. The goal is …

This phase II trial is testing whether the immunotherapy drug pembrolizumab (Keytruda) alone can work better than the usual combination of chemotherapy and radiation after surgery for head and neck cancer that has come back or is a new primary tumor. About 188 adults aged 18-79 w…

This phase II trial tests whether adapting radiation plans mid-treatment using MRI scans can reduce swallowing difficulties in patients with advanced oropharynx (throat) cancer. Participants receive standard chemoradiation, but half are randomly assigned to have their radiation p…

This study tests whether rimegepant, a dissolving tablet, can prevent migraines in children and adolescents ages 6 to under 18. About 640 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces the number of migraine days p…

This study tests whether giving less radiation to healthy lymph nodes can reduce side effects for people with oropharynx cancer. The approach uses a computer model to personalize which lymph nodes need treatment. The trial will enroll 120 patients and track if cancer returns in u…

This phase 3 trial tests whether a personalized radiation plan, which expands the treatment area based on each patient's tumor margins, can control nasopharyngeal cancer as well as the standard approach. The study includes 568 adults with newly diagnosed, non-metastatic disease. …

This study compares two treatments for people with advanced head and neck cancer who cannot use the standard drug cisplatin. About 454 participants will receive either cetuximab (a targeted antibody) or a chemotherapy combo (carboplatin + paclitaxel) alongside precise radiation t…

This study is checking how well the Solo+ tympanostomy tube works in people with middle ear infections. Researchers will review doctor notes, monitor how the tubes function after surgery, and ask patients or their parents about their experience. The goal is to gather real-world i…

This trial tests whether giving extra chemotherapy or a combination of chemotherapy and immunotherapy after standard treatment can improve outcomes for people with nasopharyngeal carcinoma. The choice of treatment is based on each patient's risk level, determined by changes in a …

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This trial is testing whether a blood test that detects HPV DNA can help doctors safely reduce the amount of radiation given after surgery for HPV-positive throat cancer. After surgery, patients with undetectable HPV DNA in their blood may receive a lower dose of radiation, while…

This trial is testing an investigational drug called ARV-6723, given as a pill, in people with advanced solid tumors. The drug is designed to help the immune system recognize and attack cancer cells. The study will test ARV-6723 alone and in combination with pembrolizumab, an imm…

This study is testing whether taking the antibiotic metronidazole and using a chlorhexidine mouth rinse for 10 days before surgery can lower the amount of bacteria living inside oral cancer tumors. The researchers will compare bacteria levels before and after treatment in 30 adul…

This trial tests whether a blood test that detects HPV DNA can help doctors personalize treatment for people with HPV-related throat cancer. Participants receive radiation therapy, with or without chemotherapy, but the intensity is adjusted based on their blood test results and c…

This phase 2 trial is testing whether the immunotherapy drug atezolizumab, given before surgery, can help treat HPV-related throat cancer that can be removed. About 20 adults with stage I oropharyngeal cancer will receive two doses of atezolizumab followed by standard surgery. Th…

This trial tests whether removing fewer lymph nodes from the neck (selective dissection, levels I-IV) works as well as the standard more extensive removal (modified dissection, levels I-V) in people with oral cancer that has spread to a single lymph node. The goal is to see if th…

This trial compares two types of neck surgery for people with oral cancer that has not spread to lymph nodes. One surgery removes lymph nodes from levels I to IV, while the other removes only levels I to III. The goal is to see whether the less extensive surgery can control cance…

This study will compare three FDA-approved biologic drugs (dupilumab, omalizumab, and mepolizumab) in 504 adults with chronic sinusitis and nasal polyps. The goal is to see which drug works best for different patients and whether simple tests can predict who will improve the most…

This phase II trial is testing whether a sentinel lymph node biopsy can guide radiation therapy to only one side of the neck in people with oral cavity squamous cell carcinoma. Currently, standard treatment often involves radiating both sides of the neck, which can harm saliva pr…

This trial tests whether a 12-week smell training program can help people who lost their sense of smell after COVID-19. Participants will sniff four different scents twice daily, with one group using rose, orange, clove, and eucalyptus, and another using cheese, coffee, strawberr…

This study tests whether a balloon coated with the drug paclitaxel, used during standard sinus surgery, can reduce the need for additional procedures or medications in adults with chronic sinusitis. About 300 participants will receive either the drug-coated balloon or a plain bal…

This study is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy (cisplatin and gemcitabine) can help people with recurrent or metastatic nasopharyngeal cancer that hasn't been treated before. About 100 participants will receive the combination int…

This trial compares two oral antibiotics—trimethoprim-sulfamethoxazole (TMP-SMX) and clindamycin—to see which works better for children with invasive MRSA infections, such as bone, joint, or deep tissue infections. About 100 children aged 60 days to 18 years will take one of the …

This phase 2 trial tests a combination of two drugs—becotatug vedotin (a targeted antibody-drug conjugate) and epirubicin (a standard chemo)—in 40 people with EGFR-positive, recurrent sinonasal adenoid cystic carcinoma that cannot be surgically removed. The goal is to shrink the …

This trial tests a new nanoparticle spray containing the steroid triamcinolone acetonide for people recovering from endoscopic sinus surgery. The spray is designed to deliver the drug directly to the nasal cavity to reduce inflammation and improve healing. Researchers compare it …

This study is for people with HPV-related throat cancer. After surgery, patients receive lower-than-standard doses of radiation and sometimes chemotherapy, based on their risk level. The goal is to keep cancer from coming back while reducing side effects like weight loss. About 1…

This study tests a new treatment for people whose nose and throat cancer has returned and cannot be removed with surgery. The treatment combines an immunotherapy drug (PD-1 antibody) with two chemotherapy drugs, followed by targeted radiation. The goal is to see if this approach …

This study tests a new drug called BL-B01D1 combined with an immunotherapy (PD-1 antibody) in people with advanced lung cancer, nasopharyngeal cancer, or other solid tumors that have spread. The goal is to see if the combination can shrink tumors and control the disease. About 57…

This trial studies people with HPV-positive oropharynx cancer whose tumors can be surgically removed. After surgery, patients are grouped by risk: low-risk patients get no further treatment, intermediate-risk get a lower dose of radiation, and high-risk get lower-dose radiation p…

This study tests an experimental drug called CUE-101 in 30 people with HPV16-positive throat cancer. The drug is given before standard treatments like surgery or chemoradiation to see if it safely boosts the body's immune cells to fight the cancer. Researchers will monitor side e…

This study tests whether a handheld device that strengthens the muscles used for breathing and swallowing can improve speech in children aged 5 to 17 with velopharyngeal dysfunction, a condition where the soft palate does not close properly, causing nasal-sounding speech. Partici…

This phase II trial tests two drugs—becotatug vedotin and pucotenlimab—given before surgery to people with advanced hypopharyngeal cancer. The goal is to shrink tumors enough to improve surgical outcomes and possibly preserve the voice box. About 52 participants will receive thre…

This phase III trial tests whether a shorter, 'immune sandwich' regimen works as well as full-course immunotherapy for locally advanced nasopharyngeal carcinoma. The experimental group gets induction chemotherapy plus two immune-targeting drugs (toripalimab and nimotuzumab), then…

This study tests the drug adalimumab (Tebiovio®) in 30 adults with non-infectious uveitis, an inflammatory eye disease. The goal is to see if the drug can control inflammation and prevent treatment failure. Participants will receive injections and be monitored for up to 24 weeks.…

This Phase III trial tests whether adding an experimental drug called becotatug vedotin to standard anti-PD1 immunotherapy can better control advanced nasopharyngeal carcinoma that has spread or returned. About 86 adults whose cancer has stabilized after initial chemoimmunotherap…

This phase 3 trial tests whether using a special scan (SPECT-CT) to guide radiation to only one side of the neck works as well as standard radiation to both sides for people with oropharyngeal cancer. The study includes 510 participants with early-stage cancer on one side of the …

This trial tests a new drug called JS207, a bispecific antibody that targets two proteins (PD1 and VEGF) involved in cancer growth and immune evasion. It is being studied in people with recurrent or metastatic nasopharyngeal carcinoma, a type of throat cancer, who have already tr…

This trial investigates whether the antiviral drug ganciclovir can help people with moderate-to-severe allergic rhinitis that doesn't improve with standard treatments. Participants receive either ganciclovir capsules or a placebo for two weeks, alongside a nasal steroid spray. Re…

This early-stage trial tests a custom-made vaccine for recurrent respiratory papillomatosis (RRP), a rare condition where non-cancerous growths keep coming back in the throat. The vaccine is made from each patient's own immune cells and designed to target the virus that causes RR…

This trial tests a vaccine called BVAC-E6E7 in people with head and neck cancer linked to HPV types 16 or 18 that cannot be removed by surgery or has spread. The vaccine is designed to teach the immune system to attack cancer cells. The study first checks safety and the best dose…

This study is testing an experimental device called a vestibular implant, which is surgically placed behind the ear to stimulate the balance nerve. The goal is to see if it can improve walking and balance in adults with long-term dizziness that hasn't improved with other treatmen…

This trial investigates whether adding ivonescimab—a drug that targets both PD-1 and VEGF—to standard chemotherapy can shrink locally advanced oral or oropharyngeal cancers before surgery. About 20 adults with resectable stage II–IVA disease will receive two cycles of the combina…

This phase 2 trial tests whether adding low-dose radiation to standard chemoimmunotherapy can better control liver tumors in people with nasopharyngeal carcinoma that has spread to the liver. The study will enroll 26 adults aged 18 to 70. Participants will receive low-dose radiat…

This study compares a personalized surgical approach using sleep endoscopy to standard tonsil removal in 240 children aged 2-17 with small tonsils and moderate-to-severe obstructive sleep apnea. The goal is to see if tailoring surgery to each child's specific airway blockages imp…

This Phase 2 trial tests a new way to give radiation for sinus cancer after endoscopic surgery. Instead of radiating the whole sinus area, doctors will use a 'dose painting' technique that targets only the areas where cancer was found. The goal is to see if this reduces side effe…

This study tests whether programming a cochlear implant based on each person's unique inner ear structure improves hearing compared to the standard one-size-fits-all approach. Adults with severe to profound hearing loss who already have a MED-EL cochlear implant will receive both…

This study tests a dog allergy immunotherapy called Alutard SQ Dog in 40 adults with moderate-to-severe dog allergy. Participants receive increasing doses over 13 weeks, then maintenance shots every 6-8 weeks for a year. Their symptoms and lung function are measured before and af…

This Phase 2 trial tests PollenVax, a new immunotherapy for people with moderate-to-severe allergic rhinitis caused by mugwort pollen. The treatment is given as four weekly shots before the pollen season. Researchers will compare symptom scores and medication use between the Poll…

This study tests whether giving three drugs (gemcitabine, docetaxel, and toripalimab) before standard radiation can safely improve outcomes for people with a specific throat cancer caused by the Epstein-Barr virus. About 24 adults with advanced but not spread cancer will receive …

This study tests whether custom 3D-printed titanium implants can safely and effectively rebuild facial bones in 30 adults with defects from injury, cancer surgery, or birth conditions. Each implant is designed from CT scans to match the patient's unique anatomy. Researchers will …

This study looks at whether people with a type of throat cancer linked to the Epstein-Barr virus can safely receive lower doses of radiation after initial chemotherapy. The goal is to see if reducing radiation can still control the cancer while causing fewer long-term side effect…

This study tests whether a single infusion of a patient's own genetically engineered immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before the patient receives standard treatment like chemo-radiation or surgery. The trial enrolls 15 adults with advanced…

This study tests a new immunotherapy for people with advanced HPV-related cancers, such as cervical, throat, anal, and penile cancers. Participants receive specially engineered immune cells designed to attack cancer cells carrying the HPV16 virus. The goal is to see if this treat…

This study tests a single surgery that combines sinus endoscopy with oral surgery to treat sinusitis caused by dental issues. 36 adults who haven't improved with standard dental or medical care will receive this procedure. The goal is to see if this combined approach works better…

This study tests a personalized approach for people with advanced nasopharyngeal cancer. After standard chemoradiation, some patients get extra therapy to prevent the cancer from returning. But this extra therapy can cause side effects. The trial uses a new risk model (RAIRI) to …

This study tests a drug called afatinib in 25 adults with Fanconi anemia who have advanced head and neck cancer that cannot be removed by surgery. Afatinib is a pill that blocks a protein helping cancer grow. The goal is to see if it can shrink tumors and control the disease. Res…

This study tests a new antibody called HMBD-001 combined with two existing cancer drugs (cetuximab and docetaxel) in people with advanced squamous cell cancers of the lung, head and neck, esophagus, cervix, or skin. The goal is to see if the combination is safe and can shrink tum…

This Phase 2 trial is testing whether adding low-dose radiotherapy to a standard chemotherapy regimen (gemcitabine and cisplatin) plus the immunotherapy drug toripalimab can help control recurrent or metastatic nasopharyngeal carcinoma. About 55 adults aged 18-65 with confirmed n…

This phase II trial is testing whether giving radiation only to the side of the neck where the cancer is found can reduce dry mouth and other side effects in people with HPV-positive oropharynx cancer. About 22 participants will receive radiation (with or without chemotherapy) to…

This study is testing whether a lower dose of radiation (30 Gy) can safely treat HPV-positive oropharyngeal cancer while reducing side effects. About 31 adults with this type of throat cancer will receive the reduced radiation along with standard chemotherapy. The main goal is to…

This study follows 900 adults with severe chronic sinusitis and nasal polyps who are taking biologic drugs. Researchers will track how these treatments affect quality of life, symptoms, and side effects over 5 years. The goal is to see which patients benefit most based on their h…

This phase 3 trial tests whether adding toripalimab (an immunotherapy) to capecitabine (a chemotherapy pill) as maintenance therapy works better than capecitabine alone for people with high-risk nasopharyngeal carcinoma. The study enrolls 264 adults aged 18-70 who have completed …

This study tests a new drug called Becotatug Vedotin in children aged 2 to 18 with certain solid tumors that have come back or spread. The drug targets a protein called EGFR found on many cancer cells. The main goal is to see if the drug is safe and to find the best dose, while a…

This study tests whether using ultrasound during oral cancer surgery helps surgeons remove tumors more completely. About 150 adults with early-stage oral cancer will be randomly assigned to standard surgery or surgery guided by real-time ultrasound. The goal is to see if ultrasou…

This early-stage trial is testing whether injecting the local anesthetic lidocaine into HPV-related throat tumors before robotic surgery is safe and might help destroy more cancer cells. About 30 adults with HPV-positive oropharyngeal cancer will receive the injection during a ro…

This study tests a combination of three drugs—an EGFR antibody, a PD-1 inhibitor, and chemotherapy—in people whose nasopharyngeal cancer has returned or spread. The goal is to see if this mix can slow or stop the cancer from growing. About 148 adults aged 18-75 who have not had p…

This study tests a combination of three drugs (sintilimab, anlotinib, and chemotherapy) in 33 adults with recurrent or metastatic nasopharyngeal cancer that has not responded to prior immunotherapy. The goal is to see if this combo can shrink tumors or control the disease. Partic…

This phase 3 trial tests whether a structured nutrition plan (including supplements, feeding tubes, or IV nutrition) helps malnourished patients with advanced nasopharyngeal carcinoma maintain weight and improve their prognosis. About 266 participants will receive either standard…

This early-phase trial is testing whether a nasal spray vaccine (WSK-IM05) combined with an immunotherapy drug (tislelizumab) can safely shrink HPV-positive throat tumors before surgery. Nine adults with newly diagnosed, resectable HPV-positive oropharyngeal cancer will receive t…

This phase II trial is testing whether combining two types of radiation (SBRT and low-dose radiation) with an immunotherapy drug (toripalimab) and chemotherapy can help control recurrent or metastatic nasopharyngeal carcinoma. The study will enroll 148 participants who have not r…

This study is testing whether taking three oral chemotherapy drugs together is safe and practical for patients with head and neck cancer that has returned or spread. The trial focuses on people living in rural Midwest areas, making it easier for them to participate from home. The…

This phase 3 trial tests whether adding an immunotherapy drug (cadonilimab) and low-dose radiation to standard chemotherapy can improve outcomes for people with advanced nasopharyngeal cancer. About 380 participants will be randomly assigned to receive either the new combination …

This phase 3 trial tests whether adding an immunotherapy drug called toripalimab to standard chemoradiotherapy helps people with recurrent nasopharyngeal carcinoma live longer. About 212 participants whose cancer has returned after prior treatment and who cannot have surgery will…

This study is for people with a rare sinus cancer called sinonasal adenoid cystic carcinoma. The treatment delivers high-dose chemotherapy directly to the tumor through a small tube in an artery, aiming to shrink it as much as possible. After three sessions, doctors check if the …

This study compares two flapless surgical techniques used alongside braces to see which better improves gum and bone changes. Forty adults with mild to moderate crowding will receive either a soft tissue graft or a bone graft during their orthodontic treatment. Researchers will m…

This study compares a standard 6-week radiation course after surgery to a shorter 3-week course for people with head and neck cancer. The goal is to see if the shorter schedule works just as well at preventing cancer from coming back. About 369 participants will be randomly assig…

This phase 3 trial tests whether adding an immunotherapy drug (PD-1 antibody) to standard chemoradiotherapy helps people with recurrent nasopharyngeal carcinoma live longer. About 212 participants whose cancer has returned after prior treatment and cannot be surgically removed wi…

This study compares two surgical techniques for treating nasopharyngeal cancer that has come back after radiation. 500 participants will be randomly assigned to receive either low-temperature plasma ablation or high-frequency electrocautery. The goal is to see which method leads …

This study tests whether it is safe to skip radiation to the lymph nodes in the neck after surgery for early-stage oral cancer. About 396 adults aged 18-70 with certain high-risk features will be randomly assigned to receive or not receive this radiation. The goal is to see if sk…

This study is testing whether a reduced dose of radiation can safely treat HPV-positive oropharyngeal (throat) cancer. About 111 patients will receive a lower total radiation dose than usual, with some also getting chemotherapy if needed. The goal is to see if this approach keeps…

This phase 3 trial tests whether adding a precise form of radiation (SBRT) to the immunotherapy drug camrelizumab helps control cancer better than camrelizumab alone in people with nasopharyngeal cancer that has spread to a few spots (oligometastatic). About 188 adults whose prim…

This study is testing whether giving less radiation, based on a patient's HPV type and levels of HPV DNA in the blood, can control throat cancer as well as standard higher doses. About 250 adults with favorable-prognosis oropharyngeal cancer will receive 70, 60, or 50 gray of rad…

This study tests two ideas at once: adding a drug called ATRA (Vesanoid) to standard treatment, and using a smaller radiation area that targets the tumor more precisely. It includes 460 adults with certain types of head and neck cancer that haven't spread across the midline. The …

This study tests whether adding an immunotherapy drug (penpulimab) to standard chemotherapy and radiation, followed by maintenance immunotherapy, works better than the usual maintenance drug capecitabine for people with high-risk nasopharyngeal cancer. About 142 participants with…

This study looks at a surgery called selective laryngeal reinnervation for people whose vocal cords are paralyzed on both sides, making it hard to breathe. Researchers will track 15 adults aged 18 to 70 to see if the surgery improves breathing symptoms and lung function. The goal…

This study is testing whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy can control HPV-positive throat cancer as well as the usual high dose (70 Gy). The goal is to reduce side effects from radiation while still keeping the cancer from coming bac…

This study tests three new ways to deliver the chemotherapy drug cisplatin directly to tumors in the mouth or lungs. The goal is to kill cancer cells while reducing side effects on the rest of the body. About 40 adults with early-stage oral or lung cancer will receive the treatme…

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study is testing whether people with early-stage HPV-positive throat cancer can be treated with radiation alone at a lower dose, instead of the usual full-dose radiation plus chemotherapy. The goal is to see if this gentler approach can keep the cancer from coming back while…

This study is for people with head and neck cancer. It compares two types of radiation therapy: one that treats only the cancer and nearby lymph nodes (INRT) and one that treats a larger area (ENI). The goal is to see if the smaller treatment area works just as well and causes fe…

This phase 2 trial tests whether anakinra (Kineret), an anti-inflammatory drug, can improve hearing in people with Meniere's disease or autoimmune inner ear disease who cannot take steroids. About 57 participants will receive daily injections of anakinra or a placebo for 42 days,…

This phase 2 trial is testing whether a year-long combination of tislelizumab (an immunotherapy) and low-dose capecitabine (a chemotherapy pill) can prevent cancer relapse in 53 patients with high-risk nasopharyngeal carcinoma. Participants have already received standard chemothe…

This study tests whether nisin, a natural preservative found in some foods, can safely change the bacteria in the mouths of people with oral cavity squamous cell carcinoma. About 40 patients will take nisin before and after their standard surgery. The goal is to find a safe dose …

This phase 2 trial is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy can help people with advanced laryngeal or hypopharyngeal cancer avoid having their voice box removed. The study will enroll 87 adults whose cancer has not been treated before…

This study tests a drug called becotatug vedotin in people with advanced nasopharyngeal cancer whose tumors didn't shrink enough after standard chemo-immunotherapy. About 59 adults will receive the drug during and after radiation therapy. The goal is to see if this approach can p…

This early-phase study tests whether specially engineered immune cells (CAR-T and TCR-T) can safely fight Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma that has returned or not responded to treatment. About 24 adults will receive one of two types of cell therapy, wit…

This study tests whether Yiyuancong, a traditional Chinese medicine made from food-like ingredients, can help people with sudden hearing loss. About 128 adults aged 18-60 will take the formula for 1-2 months, and their hearing will be measured with standard tests. The goal is to …

This study tests whether a blood test that detects HPV DNA can guide doctors to safely use a lower dose of radiation for people with HPV-related throat cancer. About 45 adults with early-stage HPV-positive oropharyngeal cancer will receive radiation and chemotherapy. The goal is …

This study looks at whether people with Takayasu arteritis, a rare blood vessel disease, can safely stop taking biologic medications after being in remission for a long time. About 40 participants who have been on biologics for at least 3 years and have no active disease will slo…

This study is for people with HPV-positive oropharyngeal (throat) cancer who have had surgery. Researchers want to see if giving a lower dose of radiation to a smaller area (just the neck, not the original tumor site) works as well as the standard higher dose. The goal is to redu…

This phase II trial is testing whether adding the immunotherapy drug Toripalimab to different platinum-based chemotherapy regimens, followed by standard chemoradiotherapy, can improve outcomes for people with locally advanced nasopharyngeal cancer. About 243 participants will be …

This phase 3 trial tests whether a new drug (Becotatug vedotin) plus immunotherapy (sintilimab) and standard chemoradiation works better than current standard treatment for high-risk nasopharyngeal cancer. About 266 adults with advanced but non-spread cancer will be randomly assi…

This study tests whether giving less radiation after surgery for certain head and neck cancers can reduce long-term side effects, like trouble swallowing, without allowing the cancer to come back. About 508 adults who have had surgery and need standard post-op radiation will be r…

This study is testing whether a dietary supplement called IDP (Immune Defense Protein) can reduce the length and severity of cold and flu symptoms in people aged 60 and older. About 300 participants will take either a low or high dose of IDP or a placebo daily during cold and flu…

This study is testing a precise type of radiation called proton therapy for people whose nasopharyngeal cancer has come back. The goal is to see if it can control the cancer while causing fewer severe side effects than standard treatments. About 52 adults with recurrent, non-spre…

This study follows 15 adults (ages 22–90) with severe, long-term balance disorders caused by inner ear damage. Participants have already received a vestibular implant, a device that electrically stimulates the balance nerve to help restore steadiness and clear vision during movem…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells, given alone or with the immunotherapy drug pembrolizumab, for people with head and neck cancer that has returned or spread. The main goals are to check safety, find the best dose, and see i…

This phase 3 trial is testing whether a lower dose of radiation, combined with chemotherapy and an immunotherapy drug called Camrelizumab, can control stage III nasopharyngeal cancer as well as the standard higher dose. About 593 patients whose tumors respond well to initial trea…

This phase II trial is testing whether giving the immunotherapy drug cemiplimab (sometimes with chemotherapy) before standard treatment can shrink tumors enough to allow less intense local therapy, such as reduced radiation or surgery. The goal is to maintain high cure rates whil…

This study tests whether a shorter, lower-dose course of radiation after robotic surgery can improve quality of life for people with HPV-related throat cancer. About 42 adults who have had robotic surgery will receive a reduced radiation schedule. The goal is to see if this appro…

This phase II trial is testing whether adding an immunotherapy drug (envafolimab) and a blood-vessel blocker (endostatin) to standard chemoradiotherapy can improve outcomes for 30 people with locally advanced nasopharyngeal carcinoma. The main goal is to see how many patients hav…

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink or control advanced head and neck cancer that has grown after initial therapy. About 40 adults whose cancer has spread or returned will receive the combination. The goal is to see how ma…

This phase II trial tests whether adding lovastatin, a common cholesterol-lowering drug, to the immunotherapy pembrolizumab can help shrink tumors in people with head and neck cancer that has returned or spread. The study will enroll 28 adults whose tumors express PD-L1. Research…

This study looks at whether giving radiation therapy after surgery can delay the return of early-stage tongue cancer in patients who have certain risk factors. About 190 adults aged 18 to 70 will be randomly assigned to either receive radiation or just be monitored. The goal is t…

This Phase 2 trial is testing whether giving the immunotherapy drug toripalimab along with standard chemotherapy before surgery or radiation can shrink HPV16-positive oropharyngeal (throat) tumors by at least 50%. The study enrolls 30 patients with advanced but localized disease.…

This study is testing whether a lower dose of radiation, guided by a blood test that detects HPV DNA from tumors, can safely treat head and neck cancer. About 90 adults with squamous cell carcinoma of the oropharynx will receive reduced radiation to the neck. The goal is to see i…

This study tests whether giving patients with a specific type of throat cancer (p16+ oropharyngeal cancer) a personalized, less intense treatment can keep cancer from coming back while reducing side effects. About 150 adults with early-stage disease will either have surgery follo…

This study is for people whose nasopharyngeal cancer has come back after initial treatment and cannot be removed by surgery. Participants first receive a combination of chemotherapy and an immunotherapy drug (PD-1 inhibitor). Those whose tumors shrink or disappear are then random…

This phase 3 trial tests whether adding the immunotherapy drug sintilimab to chemotherapy before and after surgery can improve outcomes for people with advanced oral cancer. About 104 participants will be randomly assigned to receive either the combination therapy or standard sur…

This study looks at whether using only targeted radiation (IMRT) can effectively control stage IB nasopharyngeal cancer in patients without high-risk features. About 169 adults aged 18-70 with newly diagnosed, early-stage disease will be followed to see how many remain cancer-fre…

This phase 2 trial is testing whether giving the immunotherapy drug tislelizumab along with chemotherapy before surgery can shrink advanced squamous cell carcinoma of the ear canal. The goal is to make surgery easier and safer, especially to protect important nerves near the ear.…

This study tests a combination of two immune-boosting drugs (iparomlimab and tuvonralimab) plus a targeted antibody (nimotuzumab) in people with advanced nasopharyngeal cancer that got worse after standard first treatment. About 41 adults aged 18-70 will receive the therapy to se…

This pilot study is testing whether a combination of two targeted drugs (nimotuzumab and toripalimab) plus standard chemotherapy can shrink locally advanced tonsillar cancer before surgery. Ten adults with resectable tumors will receive the treatment for 2-4 cycles, then have sur…

This study tests a custom 3D-printed splint that holds open a child's collapsing airway. The splint is made of a material that the body absorbs over about five years. The trial includes 35 children with severe tracheobronchomalacia who need breathing support. Researchers will che…

This Phase 1 trial tests TQB6411, an antibody-drug conjugate designed to bind to EGFR and c-Met proteins on tumor cells, blocking their growth signals and releasing a toxin to kill the cells. The study will enroll 216 adults with advanced malignant tumors to find the safest dose …

This study compares two radiation methods—proton therapy and standard photon therapy—for people with advanced nasopharyngeal cancer. All 300 participants will receive chemotherapy and immunotherapy alongside radiation. The goal is to see which approach causes fewer severe side ef…

This study tests whether two drugs—bosentan and dapagliflozin—can improve blood vessel function in people with large vessel vasculitis, a condition that damages arteries and raises the risk of heart attacks and strokes. Sixty adults with stable disease will take both drugs for 6 …

This study tests a vestibular implant in 15 older adults (ages 65-90) with chronic balance issues due to bilateral vestibular hypofunction. The implant electrically stimulates the inner ear to improve balance and vision. Researchers will measure changes in gait and eye reflexes o…

This study tests a vestibular implant, a device surgically placed in the inner ear to electrically stimulate balance nerves. It aims to improve balance, posture, and vision in up to 8 adults with bilateral vestibular hypofunction, a condition causing chronic dizziness and instabi…

This study is for people with advanced nasopharyngeal cancer (a type of throat cancer) whose tumors shrank significantly after initial chemotherapy and immunotherapy. It compares a lower dose of radiation therapy to the standard dose, both given with additional chemo and immunoth…

This study compares a lower dose of radiation (40.2Gy) to the standard dose (49.2Gy) for people with stage II nasopharyngeal cancer that responds well to chemotherapy. All participants also receive immunotherapy. The goal is to see if the lower dose can control the cancer just as…

This study tests whether people with HPV-positive throat cancer can safely receive a lower dose of radiation if their tumor shrinks quickly during early treatment. About 120 participants will be monitored for 2 years to see if the reduced treatment still prevents cancer from comi…

This study tests whether giving radiation only to the parts of the neck where cancer has spread works as well as treating the entire neck in people with nasopharyngeal carcinoma. About 462 adults with stage I–III disease will be randomly assigned to receive either standard or ind…

This study tests a gene therapy called Zopapogene imadenovec (Zopa) in 30 adults with recurrent respiratory papillomatosis (RRP), a condition causing non-cancerous throat tumors that often require repeated surgeries. One group will check how the virus used in the therapy leaves t…

This trial tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery. The program provides education, social support, and better coordination among doctors. Researchers will compare it to usual care in 532 adults w…

This phase II trial tests a new approach for recurrent nasopharyngeal carcinoma (a type of throat cancer) that has come back after initial treatment and cannot be removed by surgery. The treatment combines a special radiation schedule (low and high doses) with an immunotherapy dr…

This study tests a new drug (YL201) combined with an immunotherapy (toripalimab), with or without chemotherapy (cisplatin), in people whose nasopharyngeal cancer has come back or spread. The goal is to see if the combination is safe and helps control the cancer. About 202 adults …

This phase 2 trial tests HLX43, a drug that targets a protein called PD-L1 on cancer cells and delivers a toxin to kill them. It is for people with recurrent or metastatic nasopharyngeal carcinoma who have failed or cannot tolerate second-line therapy. About 70 participants will …

This phase 3 trial tests whether using a sentinel lymph node biopsy to guide radiation can safely reduce the amount of neck radiation in people with certain head and neck cancers. The goal is to lower long-term side effects like severe dry mouth while still controlling the cancer…

This pilot study is testing whether people with early-stage oral or throat cancer (T1-N0 or T2-N0) can safely have their tumor removed as an outpatient, going home the same day. The procedure also includes a sentinel lymph node biopsy to check for cancer spread. Researchers will …

This study is testing whether a lower dose of radiation after surgery can safely treat HPV-positive head and neck cancer while reducing long-term side effects. About 304 participants will receive either standard or reduced radiation, with or without chemotherapy. The goal is to s…

This study tests a new care coordination system called PRONTO-HN for head and neck cancer patients. The system uses a risk model to identify patients likely to need radiation after surgery and then coordinates appointments and alerts to reduce delays. Researchers will compare 85 …

This study tests a new surgical technique using a thin skin flap from the groin area to rebuild the mouth or throat after cancer removal. The goal is to see if it causes fewer problems at the donor site compared to standard flaps. Forty adults with head and neck cancer will be fo…

This study tests the drug belzutifan in 100 people with von Hippel-Lindau (VHL) syndrome, a genetic condition that causes tumors in various organs. Researchers will track how well the drug shrinks tumors and how long it takes for the disease to progress, while also monitoring sid…

This study looks at two methods to help doctors prescribe fewer antibiotics for children with ear infections when they aren't needed. One method uses changes to electronic health records and feedback reports for doctors. The other adds a shared decision-making tool that involves …

Researchers are evaluating a dynamic risk prediction model for severe myelosuppression in adults with nasopharyngeal carcinoma who receive systemic anticancer treatment. The model estimates the risk of grade 3 or higher anemia, low platelets, or low white blood cells during thera…

Researchers are testing whether a fluorescent dye called cRGD-ZW800-1 can help surgeons see laryngeal and hypopharyngeal tumors more clearly during total laryngectomy. The trial has two parts: first, to find the best dose of the dye by measuring how brightly it lights up tumor ti…

Researchers at Gødstrup Hospital are studying whether balance and dizziness problems in young children come from the inner ear's balance system. The study includes 30 children aged 6 months to 10 years who have delayed gross motor development or dizziness and balance issues. Chil…

Researchers are studying how often children with sensorineural hearing loss also have problems with their balance system. The study enrolls 48 children aged 3 to 10 with hearing loss in one or both ears. Children complete questionnaires and a series of balance and inner-ear tests…

Researchers at 32 medical centers in Europe, the USA, and South Africa are testing two new questionnaires designed to measure how severe chronic rhinosinusitis feels and how well it is controlled. About 1,000 patients with chronic rhinosinusitis, with or without nasal polyps, fil…

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual physical exam versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound improves acc…

This study aims to build a massive screening cohort of one million people to improve early detection of nasopharyngeal carcinoma, a cancer linked to Epstein-Barr virus (EBV). Participants aged 30 to 69 will provide blood, saliva, and nasal brush samples for EBV antibody and DNA t…

This trial tests a fluorescent probe called TTP-ICG that targets Trop2, a protein often found on oral cancer cells. Researchers will soak tissue samples from people with oral tumors in the probe and use near-infrared imaging to see if it can distinguish cancer from benign growths…

This study tests a new imaging device called the Active Biopsy Guidance System to help doctors decide when and where to take tissue samples (biopsies) from mouth lesions. About 90 adults with suspicious mouth spots or a history of oral cancer will participate. The goal is to see …

This study is testing a special camera that uses a laser to take microscopic pictures of suspicious spots inside the mouth. The goal is to see if these images can help doctors diagnose oral cancers and guide surgery. About 140 people with oral cancer will have their lesions image…

This trial tests whether a short wave infrared (SWIR) otoscope can more accurately diagnose middle ear fluid in children than a standard white light otoscope. About 100 children scheduled for ear tube surgery will have images taken with both devices. The presence or absence of fl…

This Phase 3 trial is testing whether combining a special PET scan (PSMA PET) with MRI can detect prostate cancer better than standard methods. About 204 men with suspected prostate cancer will receive the combined imaging, and results will be compared to biopsy findings. The goa…

This trial is testing a new electrochemical method to monitor HPV infection in patients with head and neck cancers, specifically oropharyngeal carcinoma. The goal is to see if tracking HPV DNA levels during treatment can help personalize therapy, potentially allowing some patient…

This early-stage trial tests a fluorescent dye attached to the cancer drug nivolumab. The dye is meant to make cancer cells glow during surgery, helping surgeons remove them more precisely. The study will enroll 40 people with head and neck cancer who are already scheduled for su…

This study is testing whether a simple saliva sample can help diagnose oral squamous cell carcinoma (OSCC), a type of mouth cancer. Researchers will look for specific DNA changes (methylation) in the saliva of 30 patients with OSCC and compare them to 30 healthy controls. If the …

This study tests a special PET/CT scan that uses radioactive tracers to find cancers that have a protein called CD70 on their surface. The cancers being studied include kidney cancer, lymphoma, and nasopharyngeal cancer. About 300 adults will receive an injection of the tracer an…

This study looks at whether a simple ultrasound at the bedside can reliably detect vocal fold motion impairment in children who are on noninvasive breathing support in the ICU. About 50 children will get two ultrasounds of their vocal folds—one while on the breathing machine and …

This study tests whether adding a special ultrasound of the tonsils to standard exams helps doctors diagnose oropharyngeal cancer more accurately. About 180 patients with suspected throat cancer will be randomly assigned to either standard diagnostics alone or standard diagnostic…

This study tests a new device that uses artificial intelligence to help diagnose ear infections, strep throat, and asthma flare-ups in children. About 84 kids aged 3 to 17 will either use the device at home with a doctor's video visit or receive standard in-person care. The goal …

This study is testing a new, high-frequency ultrasound probe that goes inside the mouth to look at suspicious spots. The goal is to see if it can accurately measure how deep a mouth cancer goes, which might help doctors diagnose it without always needing a surgical biopsy. The st…

This study tests a new device that uses special lights to look at the eardrum and detect fluid behind it, which is a sign of middle ear infection. The goal is to make diagnosis more accurate than current methods. The study will include 150 people of all ages who are scheduled for…

This study tests a special PET/CT scan that uses a tracer called FAPI-74 to find fibrosis (scar-like tissue) in the body. It includes 45 adults with conditions like head and neck cancer or tuberculosis that can cause fibrosis. The goal is to see how well the scan shows fibrosis, …

This study is testing whether a simple mouth rinse can detect HPV-related throat cancer early, before symptoms appear. Researchers will compare results from 200 people with throat cancer and 200 healthy volunteers matched by age, sex, and background. If accurate, this test could …

This study tests whether a new imaging technology called optical coherence tomography (OCT) can help doctors more accurately diagnose ear infections in children. Researchers will compare standard ear exams with OCT-enhanced exams in 235 children. The goal is to see if OCT reduces…

This study tests whether a special type of CT scan (dual-energy CT) can be as good as MRI for staging oral and throat cancers. Staging helps doctors decide the best treatment. If the CT works just as well, patients might avoid an extra MRI, get treated faster, and free up MRI mac…

This study is developing an artificial intelligence system that can recognize different parts of the throat and nasal passages and detect abnormal growths or lesions. Researchers will train the AI using thousands of endoscopy images and then test its accuracy against doctors with…

This study tests whether an AI-powered app can help doctors more accurately diagnose ear infections in young children (6-24 months) with cold symptoms. Researchers will compare standard ear exams with the AI app's analysis of eardrum photos. The goal is to see if the AI reduces u…

This early-stage study is testing a new imaging agent called 68Ga-FL-031 to see if it can better detect and stage certain cancers, including small cell lung, breast, and nasopharyngeal tumors. Ten adults with suspected or confirmed cancer will receive both the new PET scan and a …

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing sound waves from the phone's speaker and microphone. Researchers will enroll 800 people aged 8-70, including healthy volunteers an…

This study tests whether a blood test that looks for HPV DNA can help monitor patients treated for HPV-related oropharyngeal cancer. The goal is to see if the test can detect cancer recurrence earlier than standard methods, and also reduce the number of routine follow-up visits f…

This early-stage trial tests a cream made from inactivated Akkermansia muciniphila bacteria to prevent skin injury in 40 breast or head/neck cancer patients receiving radiation. The cream is applied three times daily to the radiation area. The main goal is to see if it is safe an…

This study tests whether a special fish oil (Omega Cold) can help healthy adults avoid or recover faster from colds, flu, and COVID-19. Four hundred participants aged 18–80 will take either the fish oil or a placebo daily for four months during flu season. They will report any sy…

This pilot study is testing whether a light-activated gel applied inside the nose before surgery can prevent infections afterward. Eighty adults having nasal surgery will either get the light treatment or a plain gel. Researchers will track who needs antibiotics for infection wit…

This study tests whether a chlorhexidine spray can prevent severe skin reactions caused by radiation therapy in people with nasopharyngeal cancer. About 148 participants will use the spray or a placebo during their treatment. The goal is to see if the spray reduces the chance of …

This study tests whether a gel containing diclofenac, a common anti-inflammatory drug, can prevent severe skin irritation caused by radiation therapy. About 156 adults with head/neck or breast cancer will apply the gel or a placebo to the treated skin three times daily during the…

This study tests a liquid made from cockroach extract (Meilian Fuxin) to prevent severe skin damage in head and neck cancer patients receiving radiation therapy. About 60 participants will apply the solution to their skin during treatment. The goal is to see if it reduces the ris…

This study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure h…

This study tests whether a nasal spray called OPN-375 can reduce symptoms of chronic sinusitis (like stuffy nose, discharge, and facial pain) in adolescents aged 12 to 17. About 84 teens will receive either the spray or a placebo twice daily for 12 weeks. The main goal is to see …

This study looks at whether CPAP, a machine that pushes air through a mask at night, can help people with large airway collapse (LAC). LAC causes shortness of breath, cough, and wheeze, and is often mistaken for asthma. The study will test if a larger trial is possible by checkin…

Researchers are studying whether skipping opioids during functional endoscopic sinus surgery leads to better recovery. The trial follows 104 adults with chronic sinusitis who receive anesthesia with dexmedetomidine and other non-opioid pain relievers instead of standard opioid dr…

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

This study tests a new software called Motion Reset that may prevent or reduce cybersickness—symptoms like nausea, dizziness, and headache—when using virtual reality. Healthy adults aged 18 to 60 will try different VR experiences and then play a commercial VR game while reporting…

This phase 3 trial tests whether a lozenge called BupiZenge, which contains the long-acting painkiller bupivacaine, can relieve mouth pain from radiation therapy better than the standard lidocaine rinse. About 150 adults with head and neck cancer will be randomly assigned to one …

This study tests an experimental antihistamine called rupatifen fumarate for people with seasonal allergic rhinitis (hay fever). About 550 adults aged 18 to 65 with at least a 2-year history of seasonal allergies will take either the new drug, an existing antihistamine, or a plac…

This study tests a device called SWAN that guides people through head movements to reduce motion sickness and improve balance. It is for adults with inner ear disorders, motion sickness, or those recovering from vestibular schwannoma surgery. Participants use the device at home f…

This study tests whether an injection called stapokibart can reduce nasal allergy symptoms like runny nose, congestion, sneezing, and itching in adolescents aged 12 to 17 with seasonal allergic rhinitis (hay fever). Participants receive either stapokibart or a placebo alongside t…

This study tests whether hearing aids can improve quality of life in cancer patients who develop hearing loss from platinum-based chemotherapy. Fifty-two adults currently on such chemotherapy and with confirmed hearing loss will be randomly assigned to receive a hearing aid or st…

This phase 3 trial tests whether megestrol acetate, a drug that stimulates appetite, can prevent weight loss in people with nasopharyngeal carcinoma undergoing chemoradiotherapy. Half of the 204 participants will take the drug daily for 11 weeks, and the other half will take a pl…

This trial tests a personalized program called TIHA for adults with autism who find everyday sounds painfully loud, a condition known as loudness hyperacusis. The program combines counseling, safe sound management, and gradual exposure to therapeutic sounds. Researchers will rand…

This study tests whether wearing a small nasal dilator inside the nostrils can reduce symptoms of patulous Eustachian tube dysfunction, a condition where the Eustachian tube stays open and makes a person's own voice and breathing sound loud in the ear. About 50 adults at Houston …

This study is testing a new seawater spray with essential oils to see if it safely relieves nasal congestion from colds, sinus infections, or allergies. About 101 people aged 12 and older will use the spray for 8 days. The main goal is to check if nasal stuffiness improves by at …

This study is testing a seawater spray mixed with essential oils to see how well it relieves nasal congestion from colds, sinus infections, or allergies. About 114 people aged 12 and older will use the spray for 7 days. The main goal is to see if nasal blockage improves after 3 d…

This phase II trial tests whether adding BMX-001 to standard symptom management can reduce severe mouth sores in head and neck cancer patients receiving chemoradiation. About 98 participants will receive either BMX-001 or a placebo alongside usual care. The goal is to see if BMX-…

This Phase 3 trial tests an investigational injection called SHR-1819 in adults aged 18 to 75 with seasonal allergic rhinitis (hay fever) who haven't gotten enough relief from standard treatments like nasal sprays or antihistamines. The study compares the drug to a placebo to see…

This study tests if Dymista nasal spray safely eases allergy symptoms like sneezing, stuffy nose, and itchy eyes in Chinese teenagers aged 12 to 17. About 100 participants will use the spray twice daily for two weeks. The goal is to see if symptoms improve, not to cure allergies.

This study tests the long-term safety of rimegepant, a migraine medication taken as a dissolving tablet, in children and adolescents aged 6 to 18. About 600 participants with a history of migraine will take the drug as needed for up to one year. The main goal is to check for side…

This study tests whether combining a mild electrical nerve stimulation on the forehead with standard smell training can improve smell function in adults with smell loss. Participants use a small device at home for 8 weeks while smelling four different odors. Researchers measure c…

This study tests whether closely watching jaw movement and starting physical therapy early can prevent or reduce trismus (jaw tightness) in people receiving radiation for head and neck cancer. Thirty adults will be checked weekly during treatment and given jaw exercises if their …

This study tests whether adding lymphatic pump osteopathic manipulative therapy (OMT) to standard care helps older adults recover faster from respiratory illnesses like bronchitis, sinusitis, or pneumonia. Participants aged 65 to 100 with a new respiratory diagnosis will receive …

This study will test four medical devices (HMG, PHN, PHR, TUR) in 160 adults with sore throat from acute pharyngitis or viral tonsillitis. The goal is to see if they are safe and help reduce symptoms like pain when swallowing. Participants will use the device for up to 7 days and…

This trial investigates whether Yupingfeng Powder, a traditional Chinese herbal formula, can improve symptoms and quality of life in adults with allergic rhinitis (hay fever). Participants will take the herbal granules or a placebo twice daily for 8 weeks, with follow-up for anot…

This trial tests whether placing a special synthetic membrane called Suprathel 250 on the wound after tonsil removal can reduce pain and improve healing. About 80 adults scheduled for tonsillectomy will either receive the membrane or have the wound left to heal on its own. Resear…

This trial tests a wearable-sensor system called MINDGAPS that tracks eye and body movements during balance exercises. Researchers want to see if it can improve dizziness and stability in older adults with vestibular hypofunction — a common cause of falls. The study also checks w…

This early-stage trial tests an experimental RNA immunotherapy called ITI-9001 in adults with Japanese cedar pollen allergy. The treatment aims to retrain the immune system to reduce allergic reactions. Researchers are primarily checking safety and how well people tolerate the sh…

This trial tests whether programming a cochlear implant based on the individual's inner ear anatomy (anatomy-based fitting) improves speech understanding in noisy environments and music perception compared to standard programming. The study enrolls adults with single-sided deafne…

This study tests whether programming a cochlear implant based on a person's inner ear anatomy improves hearing compared to the standard approach. Participants are adults with severe hearing loss who use a cochlear implant in one ear and a hearing aid in the other. Researchers wil…

This study is testing whether changing the low-frequency settings on a cochlear implant can improve hearing for people who are deaf in one ear but have normal hearing in the other. Twenty-two adults will try four different sound maps during their first month after implant activat…

This trial tests whether adding dexmedetomidine or magnesium sulphate to lidocaine for a peribulbar block (anesthesia around the eye) helps keep heart rate and blood pressure steady during dacryocystorhinostomy (tear duct surgery) under general anesthesia. Sixty adults undergoing…

This study tests a new treatment called ACTIVE that combines counseling (Acceptance and Commitment Therapy) with balance exercises for people with mild traumatic brain injury. Researchers want to see if it helps reduce dizziness and anxiety better than standard balance therapy al…

This study tests high-dose steroids (methylprednisolone or prednisone) in 35 head and neck cancer survivors who have nerve damage from past radiation. The goal is to find the best dose that improves symptoms like tongue weakness while limiting side effects. Participants must be a…

This clinical trial tests whether a doxepin solution spray can relieve severe breakthrough pain when swallowing, a common side effect of radiation therapy for nasopharyngeal carcinoma. About 178 patients will be randomly assigned to receive either the doxepin spray or a placebo s…

This study tests whether a combination of two existing drugs, nortriptyline and topiramate, can reduce vertigo and other symptoms in people with Meniere's disease. Forty adults with active Meniere's will take the drugs or a placebo for 8 weeks. The goal is to see if this approach…

This study tests a new pill containing three ingredients (dipyrone, caffeine, and chlorpheniramine) to see if it works as well as a standard cold medicine for relieving stuffy nose and other cold and flu symptoms. About 620 adults with early cold or flu symptoms will take either …

This study is testing four medical devices (PIR, NS, NHE, NHG) in 150 adults with acute viral rhinitis, rhinosinusitis, or rhinopharyngitis (common cold). The goal is to see if they are safe and help reduce symptoms like sneezing, runny nose, and sore throat. Participants use the…

This study tests whether a series of sexology consultations can help people who had their voice box removed due to throat cancer, along with their partners, feel better about their intimate lives. The program involves individual talks with a trained sexology nurse and questionnai…

This study tests whether a drug called methylnaltrexone is safe for people with head and neck cancer when taken for two weeks before their surgery. The drug is already used for constipation, but researchers want to see if it can be given safely in this setting. About 25 adults wi…

This study compares two dental devices—the Leaf expander and the Hyrax expander—in 30 children aged 6 to 12 who have a crossbite (when upper teeth sit inside lower teeth). The main goal is to see which expander causes less pain during the first week. Researchers will also measure…

This study looks at whether starting speech and swallowing therapy early — before and just after surgery — can help people with head and neck cancer recover better. Forty patients will either get early therapy sessions with a speech-language pathologist or the usual care. The mai…

This study tests whether a 3D-printed replica of a person's own nose can help them position their head better when using steroid nasal rinses. 200 adults with chronic sinusitis will use a daily steroid rinse for 8 weeks, with some getting the 3D model to guide their head position…

This study tests whether taking fish oil for 12 weeks can help the body adapt to cold by activating brown fat, which burns energy to produce heat. Thirty healthy adults aged 18-40 will take either fish oil or a placebo and then undergo a cold chamber challenge. Researchers will m…

This study tests whether a personalized 12-week speech, swallowing, and voice rehabilitation program can help preserve swallowing function in head and neck cancer patients after minimally invasive robotic surgery. About 53 participants will be enrolled, including those having sur…

This study tests whether a simple head-and-body movement called the Epley maneuver can quickly relieve dizziness from benign paroxysmal positional vertigo (BPPV) in the emergency department. About 118 adults with BPPV will either get the real maneuver or a fake one. Researchers w…

This study tests whether virtual reality (VR) games can make speech therapy more fun and improve how often people practice. Researchers will enroll 30 adults with voice disorders at the Glenrose Rehabilitation Hospital. Participants will use VR speech therapy games at home and in…

This phase 3 trial tests whether Houyanqing Oral Liquid, a Chinese herbal mix, can prevent or reduce severe mouth sores caused by radiation therapy in 386 nasopharyngeal cancer patients. Participants take the liquid four times daily during radiation, alongside standard care. The …

This study looks at whether endoscopic sinus surgery can improve sleep in people with chronic sinusitis and nasal polyps. Researchers will measure sleep quality before and after surgery in 30 participants. The goal is to see if removing polyps and opening blocked sinuses helps wi…

This study tests a device called NOVOCLEAR™ that uses pulsed energy to treat chronic rhinitis, a condition causing long-term runny nose, congestion, itching, and sneezing. The treatment targets nerves in the nose to reduce symptoms. Researchers will enroll 30 adults who haven't g…

This study tests two throat sprays (CDN and CW) for adults with a cough from a viral cold. About 58 people will use one of the sprays for 7 days and report how well it works and any side effects. The goal is to see if these sprays are safe and help ease cough symptoms.

This study tests whether a daily physical activity routine, started before and continued during radiotherapy, can improve physical function and quality of life for head and neck cancer patients. 80 patients with tumors of the oropharynx, larynx, or hypopharynx will be randomly as…

This study compares black seed (Nigella sativa) oil to standard steroid ear drops for treating eczema in the ear canal. 85 adults with ear eczema will use either the oil or steroid drops twice daily for 10 days. Researchers will measure changes in inflammation, itching, and pain …

This early study tests whether ivacaftor, a drug used for cystic fibrosis, can help people with chronic sinusitis caused by hard-to-treat bacteria. Twenty adults will receive either ivacaftor plus standard care or standard care alone for 14 days. Researchers will check safety, sy…

This study tests whether a device called ScentCare, used with a companion app, can improve smell and well-being in adults aged 60 and older who have lost their sense of smell. Participants will use the device or solve Sudoku puzzles twice daily for three months. Researchers will …

This study tests whether using a CPAP machine during a 6-minute walk test helps people with excessive central airway collapse (ECAC) walk farther and feel less breathless. ECAC is a condition where the central airways narrow or collapse during breathing, making exercise difficult…

This study tests a new way to give radiation for head and neck cancer. Instead of a fixed plan, the radiation is adjusted daily to match changes in the patient's body. The goal is to lower side effects like trouble swallowing and dry mouth. About 40 adults with throat or voice-bo…

This study tests two at-home treatments—smell training and a gentle nerve stimulation device—for people with long COVID who have lost or distorted their sense of smell. About 145 adults will do daily sessions at home and attend three clinic visits over 12 weeks. The goal is to se…

This study tests whether a diet low in saturated fats and rich in whole grains, fruits, and vegetables can reduce the severity of atopic dermatitis (eczema) in young adults. Researchers will track changes in skin symptoms and barrier function over two months. The goal is to see i…

This study tests an injection called TQH2722 in 300 adults with seasonal allergic rhinitis (hay fever). The goal is to see if it safely eases symptoms like sneezing, stuffy nose, and itchy eyes when added to standard allergy treatments. Participants will receive the injection and…

This study tests whether a special belt that vibrates can help people with balance disorders walk better and feel more steady. Researchers will enroll 90 adults aged 18-80 who have balance issues from conditions like inner ear problems or ataxia. Participants will use the belt an…

This study tests whether a mobile app can help people with allergic rhinitis (hay fever) stay on their allergy immunotherapy (allergy shots or under-the-tongue drops) for the full 3 years. Many people stop early, reducing the treatment's effectiveness. The app provides reminders …

This study tracks how adults with grass pollen allergy use Grassmuno® in everyday medical practice. Researchers will monitor treatment adherence and injection schedules over two years. The goal is to understand how well patients stick with the therapy and how it controls their sy…

This study tests whether a 20-minute session of passive music therapy, delivered through an app just before entering the operating room, can lower anxiety and pain in adults undergoing ear, nose, or throat surgery. Five hundred participants will be randomly assigned to receive mu…

This study tests a new method for treating cat allergies called intralymphatic immunotherapy (ILIT), where allergen extracts are injected directly into a lymph node. Thirty-six adults with cat-triggered allergic rhinitis and asthma will receive 3-4 ultrasound-guided injections. T…

This study tests whether a new nasal spray system that delivers fluticasone deeper into the nose can relieve Eustachian tube dysfunction (ETD) — a condition causing ear pressure, popping, and muffled hearing. About 80 adults with chronic ETD will receive either the active spray o…

This study tests whether using a navigation system during balloon sinus dilation improves success rates for people with chronic maxillary sinusitis. Fifty adults who have not had prior sinus surgery will be randomly assigned to receive either standard balloon dilation or navigati…

This study tests whether specially adapted beauty sessions (onco-esthetics) can help people with head and neck cancer feel better about their changed appearance after treatment. Fifty-five patients will receive three sessions, and researchers will measure how their self-image cha…

This study tests if a drug called Sapylin, given through an inhaler, can prevent or reduce painful mouth sores caused by chemotherapy and radiation for nasopharyngeal cancer. About 180 adults with advanced cancer will be randomly assigned to receive either Sapylin or the standard…

This study tests whether virtual reality exercises can help people with balance problems caused by a weak inner ear on one side. 48 adults will be split into three groups: one doing standard balance exercises, one using VR, and one doing both. The goal is to see if VR can reduce …

This study looks at whether antibiotics, nasal steroids, or nasal irrigation work best for treating sinus infections. About 3,720 adults with acute sinusitis will be randomly assigned to one of these treatments or a placebo. The goal is to see which approach provides the most sym…

This study tests a virtual reality therapy for Mal de Débarquement Syndrome (MdDS), a balance disorder causing persistent rocking or swaying sensations. Two hundred participants will undergo five days of treatment using VR to retrain their balance system. The goal is to improve s…

This Phase 2 trial tests whether using MRI to map saliva ducts before radiation therapy can reduce dry mouth in people with oropharyngeal cancer. About 98 participants will be randomly assigned to standard radiation planning or a new approach that spares the parotid ducts. The ma…

This study compares standard radiation therapy to a newer method called dose painting for people with head and neck cancer. The goal is to see if dose painting causes fewer severe mouth ulcers one year after treatment. About 100 participants will be randomly assigned to receive e…

This study tests a new under-the-tongue treatment (MM09) for people with rhinitis or rhinoconjunctivitis caused by house mite allergy, with or without mild asthma. About 736 participants aged 12 to 65 will receive either MM09 or a placebo to see if it reduces allergy symptoms and…

This study looks at whether a Chinese herbal medicine nasal rinse can help people feel better and heal faster after sinus surgery for chronic sinusitis. About 80 adults who have already had surgery will use the rinse for two months. The goal is to see if it reduces symptoms and i…

This study tests whether vestibular therapy—a set of head-movement exercises done with a physical therapist—can reduce falls in people with Alzheimer's disease who also have inner-ear balance problems. About 100 participants aged 60 and older will receive either the therapy or st…

This study compares two ways to manage pain after scoliosis surgery: a nerve block called MTP (injected near the spine) versus patient-controlled morphine (PCA). Forty adults with idiopathic scoliosis will be randomly assigned to one of the two methods. The main goal is to see wh…

This study tests whether adding neck therapy (cervical mobilization) to standard balance exercises can reduce dizziness and improve balance in people with Meniere's disease. 33 adults with Meniere's will be split into three groups: one getting only their usual medication, one add…

This study tests a new noise-reduction feature for hearing aids that uses deep neural networks to help people hear speech better in noisy settings. Fifty adults with mild-to-moderate hearing loss will listen to sentences at different noise levels while using three settings: no no…

This study compares a single dose of methadone (a long-acting opioid) given during surgery to standard short-acting opioids for pain relief after tonsillectomy in children ages 3 to 17. The goal is to see if methadone reduces the need for extra pain medication in the recovery roo…

This study looks at how well seawater nasal sprays work in everyday life for people with nasal and sinus issues like colds, allergies, or after surgery. About 1065 people of all ages, including pregnant women, will use the sprays and report their symptoms. The goal is to see if t…

This study tests a new nasal spray called ALDP001 for people with seasonal allergic rhinitis (hay fever). Researchers want to find the best dose and how often to use it to reduce symptoms like sneezing, stuffy nose, and runny nose. About 164 adults will take part, and their sympt…

This study tests whether a special massage called manual lymph drainage can help reduce swelling in the face and neck caused by radiation therapy for head and neck cancer. The study will include 40 people who have finished radiation within the past year. It compares two different…

This study tests a new antibody drug for people whose seasonal allergies (hay fever) are not controlled by standard treatments. The drug targets a protein involved in allergic inflammation. About 120 adults will receive either the antibody or a placebo, and researchers will measu…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This study aims to develop a blood test that measures B regulatory cells, which may indicate whether allergen immunotherapy (allergy shots) is successfully reducing allergic reactions. Researchers will study 80 adults with pollen or venom allergies who are starting routine allerg…

This study aims to learn more about oropharyngeal carcinoma, a type of throat cancer that can be linked to HPV. Researchers will collect blood samples from 1,000 patients before treatment and at six follow-up visits, and also gather tumor tissue when available. The goal is to bet…

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study follows 80 children aged 2-8 with cystic fibrosis to see how highly effective CF drugs (Kalydeco or Trikafta) impact sinus disease and sense of smell. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand whe…

This study follows 170 adults with cystic fibrosis and chronic sinusitis to see if sinus surgery improves lung function and quality of life compared to medical treatment alone. Participants either have surgery or continue with standard care. Researchers will track changes in brea…

This pilot study will test if parents can learn to use a digital otoscope (ear camera) at home to check for ear infections in their young children. About 40 children aged 1-4 who have had ear infections before will take part. Parents in the study group will get training and a dev…

This study will use artificial intelligence to create a risk prediction model for head and neck cancers, including cancers of the throat and voice box. Researchers will collect data from 3000 participants, including their medical history, lifestyle habits, and laryngoscopy images…

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover surgical tissue and additional samples like blood, saliva, and cheek swabs to study the…

This study will collect ear swabs from 40 people with malignant otitis externa, a severe infection of the ear canal that mainly affects people with diabetes or weakened immune systems. Researchers will culture the samples to identify the bacteria and fungi causing the infection a…

This observational study will test whether two new types of PET/CT scans can more accurately stage nasopharyngeal carcinoma and predict how well patients respond to immunotherapy before treatment. About 732 participants aged 18-70 with newly diagnosed, untreated cancer will recei…

This trial explores whether physical activity, specifically walking in different visual environments, can improve the sense of self in people with schizophrenia, borderline personality disorder, or vestibular syndromes. Participants will complete walking sessions in three environ…

This study looks at why some active young adults have trouble breathing during exercise due to their vocal cords closing when they shouldn't. Researchers will use a small wearable device on the neck, treadmill tests, and MRI scans to measure breathing patterns and vocal cord move…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study looks back at medical records of 105 people who had a minimally invasive surgery called BEVAR to treat complex aortic aneurysms. Researchers want to see if two types of stent grafts (TUVA BX and iCover) are safe and work well. No new treatments are given; the study jus…

This study will track which respiratory viruses—like flu, COVID-19, and RSV—are circulating in French primary care clinics each winter. Up to 25,000 patients with cold or flu symptoms will provide a saliva or nose swab sample. The goal is to monitor virus activity and help guide …

This study looks at immune markers in tumor tissue, saliva, stool, and blood from 250 head and neck cancer patients who cannot receive cisplatin chemotherapy. Researchers want to see if these markers can predict how well patients respond to chemoradiotherapy with docetaxel. The g…

This study investigates how balance and cognitive tasks—like walking while doing mental math—affect each other in older adults. Researchers will compare healthy seniors with those who have experienced dizziness or falls, using wearable sensors and cognitive tests. The goal is to …

This study will collect and analyze nasal tissue from 230 Greek patients with chronic sinusitis (with or without nasal polyps) to identify different inflammation patterns, called endotypes. By understanding these patterns, researchers hope to better match patients with the most e…

This study investigates why some people with bilateral vestibular hypofunction—a chronic balance disorder—experience more severe symptoms than others. Researchers will use advanced brain imaging (MRI) and a battery of vestibular function tests in about 80 patients and 40 healthy …

This study follows 30 people with chronic sinusitis and nasal polyps who are starting dupilumab, a medication that can help restore smell. Researchers want to see if the degree of nasal blockage or specific electrical signals from the brain can predict who will regain their sense…

This study tests whether offering hearing tests close to home or remotely increases how many head and neck cancer patients get their hearing checked during treatment. Many patients on cisplatin chemotherapy or radiation near the ear can lose hearing, but not all complete recommen…

This study is testing whether wearing a fitness tracker (like a Fitbit) can give doctors a better picture of how active cancer patients are, and whether that activity level relates to how well they are doing overall. About 590 people with various cancers will wear activity monito…

This study follows 19 adults with hearing loss who already received a cochlear implant that releases a steroid to reduce inflammation. Researchers will check how well the implant works over 5 years by measuring electrical signals and tracking any side effects. The goal is to see …

This study aims to collect and analyze genetic information from 300 Taiwanese patients with oropharyngeal cancer. Researchers will use advanced DNA sequencing to find genetic changes linked to the disease. The goal is to improve understanding and help design future treatments or …

This study looks at people with smell loss caused by chronic rhinosinusitis. Participants will undergo a 3-month smell training program. Researchers will measure changes in smell function, mental health, and immune markers in blood and tissue samples. The goal is to understand th…

This study looks at tongue strength and endurance in people who have had part of their tongue removed due to oral tongue cancer. Researchers will use a device called the Iowa Oral Performance Instrument (IOPI) to measure tongue pressure. Some participants will also use the IOPI a…

This 18-month study tests whether a smartphone app with game-like features can help adults aged 40+ with a reduced sense of smell become more active. 110 participants will be randomly assigned to either a full-dose programme aiming to double their daily steps or a low-dose contro…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This pilot study looks at how different types and intensities of exercise affect muscle recovery in people taking statins compared to those not on statins. Researchers will test cycling and resistance training at various levels, measuring muscle damage markers and pain sensitivit…

This study follows people with a rare and advanced cancer of the nasal cavity and sinuses called T4 sinonasal adenoid cystic carcinoma. All participants receive the standard treatment: surgery followed by radiation therapy. The goal is to measure how long people live without the …

This study is looking at whether people with a common inner-ear condition called benign paroxysmal positional vertigo (BPPV) have lower vitamin D levels than those without it. Researchers will compare vitamin D in 160 adults — half with BPPV and half without. The goal is to see i…

This study investigates why some children still have speech problems (velopharyngeal insufficiency) after cleft palate surgery. Researchers will use real-time MRI to look at how the soft palate moves and its muscle structure in children aged 7 to 12. By comparing children with di…

This study collects nasal cells from 100 adults during planned nose surgery. The cells are grown in the lab to create a realistic model for testing how well drugs are delivered and work. The goal is to build a cell collection that helps improve treatments for respiratory infectio…

This study tests a device called SpiderMass that analyzes tissue molecules in real time during tongue cancer surgery. The goal is to help surgeons instantly tell cancerous from healthy tissue, so they can remove all the tumor in one operation. Currently, about 15-30% of patients …

This study collects a small sample of tissue from inside the nose to learn how the sense of smell changes in people with Alzheimer's. Researchers will compare samples from healthy volunteers and those with early or mild Alzheimer's. The goal is to understand the biology behind sm…

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study looks at whether a vestibular implant (a device that helps with balance) can improve how people with severe inner ear damage perform tasks like staying upright, navigating, and thinking. About 20 people who already have the implant will be tested with it on and off, an…

This study is collecting blood and tumor samples from 40 people with HPV-related oropharynx cancer to find biological markers that could predict how the disease will progress. Researchers will measure HPV DNA levels in the blood and analyze immune cells to better understand the b…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This observational study is testing whether a new tool called RAIRI can better identify which patients with nasopharyngeal cancer might benefit from additional therapy after standard chemoradiation. About 900 adults with non-metastatic disease will be followed to see if the RAIRI…

About 30 million US adults suffer from nasal sinus disease, often causing nasal obstruction and loss of smell. This study from Ohio State University will test a nasal plug (similar to a swimmer's nose clip) as a tool to better evaluate these symptoms. Researchers hope to develop …

This study tests a printed decision aid that helps people with chronic hypertrophic rhinitis compare five surgical options. About 158 participants will either get standard counseling or the extra aid. Researchers will measure how certain patients feel about their choice and wheth…

This study aims to grow miniature versions of head and neck tumors, called organoids, from patient samples. Researchers will test different cancer drugs on these organoids to see which ones work best. The goal is to eventually use this approach to tailor treatments to each patien…

This study looks at 50 people with nasopharyngeal cancer that has come back or spread. Researchers will use advanced lab tests (multi-omics) to see if they can predict how well a combination of chemotherapy, radiation, and immunotherapy works. The goal is to find better ways to p…

This study looks at how immunotherapy drugs (anti-PD-1) affect bone strength in people being treated for cancer. Researchers will measure bone density and blood markers over a year in 25 patients. The goal is to understand if these treatments increase fracture risk, so doctors ca…

This international study aims to improve how doctors stage nasopharyngeal cancer by collecting data from 5,000 patients across multiple countries. Researchers will use this information to refine the TNM staging system and combine it with other factors like biomarkers. The goal is…

This study is looking for 530 adults with hay fever in South-Eastern Australia to help create a tool that predicts thunderstorm asthma. Participants will have allergy and lung function tests, then track their symptoms during spring for two years. The goal is to find warning signs…

This study is testing whether a nasal allergen provocation test (NAPT) can help doctors start and monitor allergy immunotherapy more effectively. Researchers will follow 200 adults with allergic rhinitis who are beginning immunotherapy, using the NAPT along with blood tests and s…

This global registry is collecting information from 1,000 people with Takayasu's arteritis, a rare disease that inflames and narrows large arteries. Researchers will analyze patients' symptoms, lab results, imaging, and treatments to see how the disease behaves and is managed aro…

This study looks at whether a feature called tumor budding can help doctors decide if early-stage oral cancer patients need neck lymph node removal. About 524 participants will be randomly assigned to either have the main tumor removed alone or also have neck dissection. The goal…

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study is observing 120 patients with sinonasal or skull-base tumours at a specialist ear, nose, and throat centre. Researchers are tracking how these conditions are managed, what the outcomes are, and how patients' quality of life changes. The goal is to better understand cu…

This study looks at 220 people with HPV-related oropharynx cancer to see if certain gene mutations (TRAF3 and CYLD) and levels of HPV DNA in the blood can predict if the cancer will come back after treatment. Participants give blood samples and fill out quality-of-life questionna…

This study is checking how safe and effective the Propel sinus implant family is when used as part of standard care for chronic rhinosinusitis in Japan. About 100 people who have had sinus surgery will be followed for 3 months. The main goal is to see how their symptoms change us…

This study looks at whether a balance exercise called IVA is safe and helpful for adults who have vision problems, with or without inner-ear balance issues. Researchers will compare two groups: people with vision problems only and those with both vision and inner-ear problems. Pa…

This study looks at how common hyperacusis (sensitivity to everyday sounds) and misophonia (strong negative reactions to specific sounds) are among teachers, and whether these conditions add to their work stress. Researchers will survey 500 teachers in Turkey to measure these sen…

This study is looking at whether people with benign paroxysmal positional vertigo (BPPV) have differences in their autonomic nervous system compared to healthy people. Researchers will measure heart rate variability (HRV) in 104 participants (52 with BPPV and 52 matched controls)…

This study looks at how abnormal blood vessel growth (angiogenesis) contributes to various skin diseases like rosacea, psoriasis, and certain tumors. Researchers will collect skin samples from 85 volunteers aged 16 and older to analyze markers of angiogenesis. The goal is to bett…

This study aims to uncover genetic and biological differences between people with Menière's disease, those with vestibular migraine, and healthy individuals. Researchers will analyze blood samples from 250 participants to look for specific gene variations and biohumoral factors. …

This study tests a virtual reality (VR) game to measure hand-eye coordination in children aged 7 to 17 with and without chronic balance (vestibular) disorders. Researchers want to see if the VR tasks are reliable and fun for kids, and how balance problems affect coordination. The…

This large observational registry aims to collect data from over 13,000 adults across Europe with rare head and neck cancers, including cancers of the nasopharynx, nasal cavity, salivary glands, and middle ear. Researchers will track patient outcomes like survival, treatment resp…

This study follows 1,200 adults with asthma (with or without nasal polyps) for up to 7 years to see how their condition changes over time. Researchers will track symptoms, treatments, and biomarkers in blood and breath. The goal is to better understand different types of asthma a…

This study is testing a new tool designed to predict side effects from cancer treatment in elderly patients (70+) with advanced head and neck cancer. The goal is to see if the tool can help doctors choose safer treatments. Only 3 participants are being enrolled, making this a ver…

This study looks at how often young children get ear infections from RSV, a common virus. Researchers will track 1900 children under 2 years old to see how many have RSV-related ear infections, with or without bronchiolitis. The goal is to better understand the burden of RSV in t…

This study collects a small sample of fluid from the ears of children aged 3 months to 15 years who have a draining ear infection (otorrhea). The goal is to identify which bacteria are present using standard lab tests and newer molecular methods. By understanding the bacterial ca…

This study looks at whether a partial problem with a salt channel (CFTR) in the nose contributes to chronic sinusitis. Researchers will measure how well the nose clears mucus in 20 people with sinusitis and healthy volunteers. The goal is to understand the disease better, not to …

This study looks at whether orthodontic treatments like Twin Block and Hyrax appliances can improve breathing in children aged 8-14 with small jaws and narrow upper airways. Researchers will use 3D scans to measure changes in airway shape and airflow. The goal is to understand if…

This study is testing a blood test that looks for tiny pieces of cancer DNA in the bloodstream of people with throat cancer. The goal is to see if this test can track how well treatment is working and spot if the cancer comes back earlier than current methods. Researchers will co…

This large observational study is checking how pneumococcal vaccines have changed the types of bacteria living in children's noses. Researchers will compare healthy children and those with ear infections to see which bacterial strains are present and whether they resist antibioti…

This study aims to translate and test the Situational Vertigo Questionnaire (SVQ) in Turkish. The SVQ measures dizziness triggered by visual environments like supermarkets or driving. Researchers will check if the Turkish version is valid and reliable by comparing it with other d…

This study looks at 1,000 children (ages 5-18) with dust mite allergies to see if customizing allergy shots based on their specific mite protein sensitivities leads to better symptom control. Participants get a detailed blood test to map their allergy profile and are followed for…

This study looks at whether changes in the bacteria living in your mouth and gut (the microbiome) are linked to head and neck cancer. Researchers will collect stool and saliva samples from 60 people—half with cancer and half without—to compare their microbial makeup. The goal is …

This study looks at how cancer and its treatments change a person's sense of taste and smell, and how that affects their eating and nutrition. Researchers will follow 306 people newly diagnosed with cancer of the mouth, throat, colon, or liver. They will use questionnaires, taste…

This study explores whether people who seek help for both their allergies and their mental health (like anxiety or depression) have better control over their symptoms. Researchers will look at health records from 200,000 adults over several years. The goal is to understand if com…

This study aims to find out how many healthy adults over 40 carry high-risk HPV in their mouth, which can lead to oropharyngeal cancer. Researchers will test 20,000 volunteers in the Czech Republic to develop a better screening method. The goal is to identify people at risk earli…

This study is testing whether liquid biopsies (blood tests that look for bits of HPV and tumor DNA) can help doctors monitor treatment and spot early signs of cancer returning in people with HPV-related cervical and oropharyngeal cancers. Researchers will follow 480 participants …

This study looks at how indoor air and dust pollutants in classrooms impact children's allergies and lung function. Researchers will monitor 100 children, comparing those with allergies to those without, using questionnaires, allergy tests, and breathing tests. The goal is to ide…

This long-term study follows 1,000 people with eczema and related allergies, plus healthy volunteers, to see what factors help the disease go into remission. Researchers will collect medical and lifestyle data to find patterns and possible biomarkers. The goal is to better unders…

This study tracks the pregnancy experiences of women with vasculitis, a group of rare diseases causing blood vessel inflammation. Researchers will use online surveys to understand how vasculitis affects pregnancy and what outcomes occur. The goal is to gather information to help …

This study collects tissue samples from 1,000 people with various forms of vasculitis, a group of rare inflammatory blood vessel diseases. Researchers will analyze the samples alongside clinical data to identify genes that increase risk and to spark new ideas for diagnosis and tr…

This study uses two online questionnaires to learn about the experiences of people with Takayasu arteritis and how doctors manage the condition. About 50 patients and an unspecified number of physicians in the UK will share their views on symptoms, treatment priorities, and unmet…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study collects DNA samples and medical information from 1,000 people with various forms of vasculitis (blood vessel inflammation). Researchers will analyze the data to identify genes that increase the risk of developing these severe diseases. The goal is to better understand…

This study measures how well people with and without vestibular (balance) disease can sense motion through vision and balance. Researchers hope to learn how aging and disease change motion perception. About 300 healthy adults and patients with balance disorders will participate i…

This study is testing whether a simple symptom score questionnaire (SCST) is acceptable and useful for patients with allergic rhinitis during ENT check-ups. The goal is to see if this tool helps doctors monitor severity and response to treatment consistently. Thirty adults will p…

This study looks at whether sleep disorders make vertigo worse for people with Ménière's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Researchers will track 100 adults to see if those with more severe vertigo also have more sleep problems. Th…

This study looks at whether a blood test that finds circulating tumor cells (CTCs) can help decide if oral cancer patients need extra chemotherapy after standard treatment. About 100 patients who have completed surgery and chemoradiotherapy will be tested. If their CTC count is h…

This study is a registry that follows 500 people with smell or taste disorders to learn more about how these conditions progress and affect quality of life. Participants complete standard tests and questionnaires during their clinic visits. The goal is to better understand these …

This study looks at how two rare diseases that cause blood vessel inflammation—Takayasu arteritis and Behçet's disease—affect physical strength, breathing, daily function, and emotional well-being. Researchers will compare 30 participants (patients and healthy volunteers) using s…

This study enrolls 500 adults with nasopharyngeal carcinoma (stage I-III) who are receiving chemoradiotherapy with either proton or photon radiation. Researchers will collect imaging scans and blood samples to find markers that predict how well the cancer responds, side effects, …

This study is for people with HPV-related throat cancer who have surgery to remove their tumor. Researchers are testing whether a blood test that looks for leftover tumor DNA can safely identify patients who do not need additional radiation. The goal is to reduce side effects by …

This study tests whether a special PET scan can show how much of a certain protein (SSTR2) is present in nasopharyngeal cancer tumors. Ten adults with EBV-related nasopharyngeal cancer will get the scan before and after starting chemotherapy or chemoradiation. The goal is to see …

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…

This study observes 200 adults with head and neck cancer who need facial reconstruction using a free bone flap after surgery. Researchers will track their medical visits, treatments, and costs over time using national health data. The goal is to describe typical care pathways and…

This study follows 150 people with Takayasu's arteritis that also affects the lung arteries. Researchers will track their health over time, including how far they can walk in six minutes and their risk of death. The goal is to better understand the disease and its long-term outlo…

This study is looking at 50 adults with a rare genetic nerve disorder called RFC1-ataxia or CANVAS, which causes problems with balance, coordination, and sensation. Researchers will take blood samples and skin biopsies over 12 months to measure markers of cell stress and damage. …

This study looks at nerve-related problems like numbness, tingling, and pain in people who have been treated for oral cavity or throat cancer. Researchers will use simple tools like brushes and temperature tests to map these sensations. The goal is to better understand how common…