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Could a sleep apnea machine help people with collapsed airways?

NCT ID NCT07504926

Symptom relief Sponsor: Liverpool School of Tropical Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times

Summary

This study looks at whether CPAP, a machine that pushes air through a mask at night, can help people with large airway collapse (LAC). LAC causes shortness of breath, cough, and wheeze, and is often mistaken for asthma. The study will test if a larger trial is possible by checking how many people join, stay, and find CPAP acceptable. Sixty adults with LAC will be recruited, and some will use CPAP while others continue usual care. The goal is to gather information, not to prove CPAP works yet.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CPAP (continuous positive airway pressure) device
What this could lead to
If this works, it could point toward a new treatment for large airway collapse, reducing breathing problems and improving quality of life.
What could go wrong
This is a very early feasibility study with only 60 people. It is not designed to prove CPAP works, just to see if a larger trial is possible. CPAP may not help everyone and can cause discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Adult (≥18 years) at visit 1 2. Able to provide informed consent 3. Prior confirmation of LAC (diagnosed either radiographically or with bronchoscopy) 4. Respiratory co-morbidities optimised 5. ≥1 course of antibiotics and/or prednisolone for an exacerbation of chronic airway disease in the preceding 12 months before visit 1. Exclusion Criteria 1. Contraindication to CPAP as per British Thoracic Society (BTS) guidelines 2. Already using domiciliary CPAP (including privately purchased) 3. Known obstructive sleep apnoea syndrome (OSAS) eligible for CPAP 4. Suspected OSAS that is awaiting further investigation 5. Pregnant or planning a pregnancy in the next 12 months

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Conditions

The condition(s) this trial relates to.

asthma congenital tracheomalacia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma Large airway collapse

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Royal Liverpool Hospital

    RECRUITING

    Liverpool, United Kingdom

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