Fish oil might keep you warmer in the cold, study suggests
NCT ID NCT05822141
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking fish oil for 12 weeks can help the body adapt to cold by activating brown fat, which burns energy to produce heat. Thirty healthy adults aged 18-40 will take either fish oil or a placebo and then undergo a cold chamber challenge. Researchers will measure core temperature, shivering, and comfort to see if fish oil makes a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Fish oil (omega-3 fatty acids)
- What this could lead to
- If it works, this could point toward a way to improve cold tolerance and comfort in cold environments.
- What could go wrong
- This is a small, early-stage study in healthy young adults, so results may not apply to others. The effect of fish oil on cold tolerance is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2023
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male and female, between the ages of 18 to 40 years. * Body Mass Index (BMI) of 18.5 to 24.9 kg/m2 * Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ) and the Physical Activity Readiness Questionnaire (PAR-Q+) Exclusion Criteria: * History of smoking or recreational smoking, hyperlipidemia, hypertension/cardiovascular disease, diabetes, renal disease, neurological disease, metabolic disease, and bleeding disorders or delayed clotting time. * Taking SSRI's (antidepressants and anxiety medication), ADD/ADHD medication, and chronically consume pain medication (Aleve, Tylenol, CBD, etc). * Have or have had chronic disorders of the rectum (e.g., cancer, surgery, active hemorrhoids, etc.) or who currently have related acute conditions (diarrhea, constipation, etc.). * Have or have had a diagnosis of disorders related to immune suppression and/or autoimmune disease. * Are pregnant or planning on being pregnant. * Resting blood pressure of \> 130mmHg systolic or 90 mmHg diastolic. * Resting Pulse rate of \> 100 bpm. * History of regularly consuming fish oil supplements and/or regularly eating more than one fish meal per week. * Consuming more than one fish meal per week during the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Human Perfromance Lab, Indiana University
RECRUITINGBloomington, Indiana, 47405, United States
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