Sniffing your way back: does scent therapy rebuild COVID-Shattered smell?
NCT ID NCT05384561
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This trial tests whether a 12-week smell training program can help people who lost their sense of smell after COVID-19. Participants will sniff four different scents twice daily, with one group using rose, orange, clove, and eucalyptus, and another using cheese, coffee, strawberries, and lemon. The study compares the two scent sets to see which, if any, leads to greater improvement in smell function and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Smell training with different odor sets
- What this could lead to
- If effective, smell training could become a simple, at-home therapy to help people regain their sense of smell after COVID-19.
- What could go wrong
- This is a small trial, and results may vary. Some people may not improve, and the benefit could be modest or short-lived.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2022
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient diagnosed positive for COVID-19 with persistent olfactory dysfunction * Willing and able to provide written informed consent * Understand and read the French language * Have an internet connection and a working email address Exclusion Criteria: * Anosmia and hyposmia pre-covid-19 * Be known chronic rhinosinusitis with or without nasal polyposis * Have received radiotherapy or chemotherapy for Head and Neck Tumors * Have a diagnosis of Alzheimer's, Parkinson's, multiple sclerosis or any other neurodegenerative disease 5. Have a brain tumor or ENT diagnosis 6. History of naso-sinus surgery; 7. History of traumatic brain injury
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Université du Québec à Trois-Rivières
RECRUITINGTrois-Rivières, Quebec, G8Z 4M3, Canada
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