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Radiation after surgery may keep tongue cancer at bay for High-Risk patients

NCT ID NCT07402525

Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving radiation therapy after surgery can delay the return of early-stage tongue cancer in patients who have certain risk factors. About 190 adults aged 18 to 70 will be randomly assigned to either receive radiation or just be monitored. The goal is to see if radiation improves how long patients stay cancer-free and their overall survival, while also checking side effects and quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 190 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jul 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years old and ≤ 70 years old, gender not limited; 2. Newly treated patients (who have not undergone radiotherapy, chemotherapy, or targeted therapy before); 3. Complete resection of the tumor with naked eye and no residual tumor observed in postoperative pathology; 4. The lesion is limited to the anterior 2/3 of the tongue (active part of the tongue); 5. Postoperative pathological diagnosis was squamous cell carcinoma of the tongue; 6. According to AJCC 8th edition, the pathological TNM staging is T1-2N0M0; 7. Having at least one risk factor: vascular cancer thrombus, nerve invasion, moderate or low differentiation; 8. The general status score of the Eastern Cancer Collaboration Group (ECOG) is 0-2 points; 9. Not participating in other clinical trials within the previous 4 weeks prior to screening; If other trials fail to screen cases, but meet the requirements of this trial, they can be enrolled. Exclusion Criteria: 1. Patients who invade the oropharynx, mouth floor, cheeks, neck, and other organs; 2. Have received chemotherapy or other anti-tumor drugs; 3. Previously received radiation therapy for the head and neck area; 4. Patients with active autoimmune diseases that require systemic treatment in the past; 5. Pregnant or lactating women; 6. Individuals with acute infections that are difficult to control; 7. Patients with drug abuse, drug abuse, long-term alcoholism and AIDS; 8. The subjects also have other known invasive malignant tumors (excluding those with no evidence of tumor recurrence through treatment and a duration of more than 2 years); 9. Researchers believe that there are other conditions that hinder patients from participating in this trial.

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Conditions

The condition(s) this trial relates to.

Squamous Cell Carcinoma of Head and Neck squamous cell carcinoma of the oral tongue

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral tongue squamous cell carcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    28 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cancer Hospital Chinese Academy of Medical Sciences

    NOT_YET_RECRUITING

    Chaoyang, Beijing Municipality, 100020, China

  • Cancer prevention and treatment center, sun yat-sen university

    NOT_YET_RECRUITING

    Guandong, Guangdong, 510060, China

  • Fudan University Shanghai Cancer Center

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

  • Fujian Cancer Hospital

    NOT_YET_RECRUITING

    Fuzhou, Fujian, 350014, China

  • Harbin Medical University Cancer Hospital

    NOT_YET_RECRUITING

    Harbin, Heilongjiang, 150081, China

  • Hunan Provincial People's Hospital

    NOT_YET_RECRUITING

    Changsha, Hunan, 410005, China

  • Hunan cancer hospital

    NOT_YET_RECRUITING

    Changsha, Hunan, 410008, China

  • Huzhou Center Hospital

    NOT_YET_RECRUITING

    Huzhou, Zhejiang, 313000, China

  • Jiangxi Cancer Hospital

    NOT_YET_RECRUITING

    Nanchang, Jiangxi, 330029, China

  • Ningbo Medical Center Lihuili Hospital

    NOT_YET_RECRUITING

    Ningbo, Zhejiang, 315040, China

  • Renmin Hospital of Wuhan University

    NOT_YET_RECRUITING

    Wuhan, Hubei, 430060, China

  • Sichuan Cancer Hospital & Institute

    NOT_YET_RECRUITING

    Chengdu, Sichuan, 610041, China

  • The Affiliated Hospital of Qingdao University

    NOT_YET_RECRUITING

    Qingdao, Shandong, 266000, China

  • The First Affiliated Hospital of Bengbu Medical University

    NOT_YET_RECRUITING

    Bengbu, Anhui, 233030, China

  • The First Affiliated Hospital of China Medical University

    NOT_YET_RECRUITING

    Shenyang, Liaoning, 110001, China

  • The First Affiliated Hospital of Dalian Medical University

    NOT_YET_RECRUITING

    Dalian, Liaoning, 116011, China

  • The First Affiliated Hospital of Fujian Medical University

    NOT_YET_RECRUITING

    Fuzhou, 350005, China

  • The First Affiliated Hospital of Wenzhou Medical University

    NOT_YET_RECRUITING

    Wenzhou, Zhejiang, 325000, China

  • The First Hospital of Jilin University

    NOT_YET_RECRUITING

    Changchun, Jilin, 130033, China

  • The Huashan Hospital Affiliated to Fudan University

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200040, China

  • The Second Affiliated Hospital of Dalian Medical University

    NOT_YET_RECRUITING

    Dalian, Liaoning, 116027, China

  • The first affiliated hospital, college of medicinle, Zhejiang University

    RECRUITING

    Hangzhou, Zhejiang, 310009, China

  • Tianjin Medical University Cancer Institute & Hospital

    NOT_YET_RECRUITING

    Tianjin, Tianjin Municipality, 300060, China

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    NOT_YET_RECRUITING

    Wuhan, Hubei, 430030, China

  • Xiangya Hospital of Central South University

    NOT_YET_RECRUITING

    Changsha, 410008, China

  • Zhejiang Cancer Hospital

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, 310009, China

  • the First Affiliated Hospital of Xi'an Jiaotong University

    NOT_YET_RECRUITING

    Xi'an, Shaanxi, 710061, China

  • the second affiliated hospital of Zhejiang University Hangzhou, Zhejiang, China, 310009

    RECRUITING

    Hangzhou, Zhejiang, China

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