Blood test may allow safer radiation for head and neck cancer
NCT ID NCT05962242
First seen Feb 05, 2026 · Last updated Jun 22, 2026 · Updated 27 times
Summary
This study is testing whether a lower dose of radiation, guided by a blood test that detects HPV DNA from tumors, can safely treat head and neck cancer. About 90 adults with squamous cell carcinoma of the oropharynx will receive reduced radiation to the neck. The goal is to see if this approach controls the cancer as well as standard radiation while causing fewer side effects.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Bon Secours
NOT_YET_RECRUITINGRichmond, Virginia, 23114, United States
Contact
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Eastern Virginia Medical School
NOT_YET_RECRUITINGNorfolk, Virginia, 23507, United States
Contact
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Miami Cancer Institute
RECRUITINGMiami, Florida, 33176, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Virginia
RECRUITINGCharlottesville, Virginia, 22908, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23284, United States
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiation therapy (external beam radiation to head and neck)
What this could lead to
If successful, this could lead to a treatment approach that uses lower radiation doses for certain head and neck cancers, potentially reducing side effects while maintaining cancer control.
What could go wrong
This is a Phase 2 trial with only 90 participants, so results are preliminary. The lower radiation dose might not control the cancer as well as standard treatment, and there is still a risk of side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.