University Of Virginia

This phase 2 trial tests an experimental drug called CIR-0602K in 40 adults with type 1 diabetes who already use an automated insulin delivery system. The drug aims to improve how the body responds to insulin, helping people spend more time in a healthy blood sugar range and poss…

This study tests whether 24 weeks of exercise training, the drug liraglutide, or both together can improve blood flow in the heart and muscles and help insulin work better in adults with metabolic syndrome. 80 participants will be randomly assigned to one of four groups: control,…

This early-stage trial tests whether Brezavvy, a diabetes drug, can improve blood flow in the tiny vessels of the heart and reduce chest pain in women who have angina but no blocked arteries. 150 women will take either the drug or a placebo for 12 weeks and undergo heart scans an…

This study tests a new treatment for people with metastatic breast or prostate cancer that has stopped responding to standard therapies. Participants receive infusions of their own immune cells that have been armed with a special antibody to help them find and attack cancer cells…

This study tests whether giving two common heart medications (a beta blocker and an ACE inhibitor) before and during intensive chemotherapy can prevent heart damage in people newly diagnosed with acute myeloid leukemia (AML). About 70 adults will be randomly assigned to receive t…

This study is testing whether a lower dose of radiation, guided by a blood test that detects HPV DNA from tumors, can safely treat head and neck cancer. About 90 adults with squamous cell carcinoma of the oropharynx will receive reduced radiation to the neck. The goal is to see i…

This early-stage trial tests a single dose of a lab-made clotting protein (recombinant von Willebrand factor) in 12 adult patients on ECMO who have major bleeding. The goal is to see if the drug is safe and how it behaves in the body. If successful, it may lead to a new way to co…

This study tests three different antibiotics to treat small intestine bacterial overgrowth (SIBO) in 60 malnourished Bangladeshi children. The goal is to find which antibiotic works best to clear the overgrowth, which may help prevent growth stunting and malnutrition. Children wi…

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can improve treatment outcomes. Researchers will enroll 200 adults and children with active, drug-sensitive tuberculosis in Tanzania. The goal is to see if personalized dosing helps m…

This study is testing whether the BCG vaccine, originally developed for tuberculosis, can be safely used to treat Mycobacterium avium complex (MAC) lung disease. About 48 adults with MAC lung disease will receive either a BCG injection or a placebo. Researchers will monitor side …

This early-phase study tests a new treatment for adults with acute myeloid leukemia or myelodysplastic syndrome who still have detectable cancer cells after standard therapy. The treatment uses the patient's own blood cells, which are armed with a special antibody to better targe…

This study tests whether an artificial pancreas system can improve blood sugar control and, in turn, reduce heart disease risk in people with type 1 diabetes. The system combines an insulin pump with a continuous glucose monitor to mimic a healthy pancreas. Researchers will measu…

This study tests an experimental treatment for adults with advanced melanoma who are already getting immunotherapy and planning surgery. The treatment combines focused ultrasound (using sound waves to heat and destroy tumor tissue) with an injection of a drug called polyICLC that…

This study tests a pharmacist-led program called QuitAid to help rural smokers in Appalachia quit. About 768 participants will receive nicotine patches and may also get extra support like text messages, phone coaching, or longer medication. The goal is to see which combination wo…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The treatment uses the patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Participants receive these cells through an …

This study tests if a combination of two drugs (romidepsin and oral azacytidine) works better than standard single drugs for people with peripheral T-cell lymphoma (PTCL) that has returned or not responded to prior therapy. About 50 adults will be randomly assigned to either the …

This study looks at whether natural estrogen given through a skin patch improves bone strength more than natural estrogen pills or a synthetic birth control patch in women aged 14–30 with functional hypothalamic amenorrhea (missed periods due to stress, low weight, or exercise). …

This study tests whether giving two doses of ketamine along with the standard drug levetiracetam stops prolonged seizures (status epilepticus) better than levetiracetam alone. About 770 people aged 1 year and older who are still seizing after first-line treatment will take part. …

This early-stage trial tests a new treatment for a fast-growing brain cancer called glioblastoma. It combines special immune cells (EGFR BATs) with low-intensity focused ultrasound to temporarily open the blood-brain barrier, allowing more treatment to reach the tumor. The study …

Researchers are testing a new blood test that might predict if a pregnant woman will develop postpartum depression (PPD). The study will enroll 500 pregnant women, take a blood sample in the third trimester, and follow them for 6 months after birth to see who develops depression.…

This study tests whether a special MRI using inhaled xenon gas can detect early signs of rejection in lung transplant patients. Researchers will compare MRI results with lung function tests and cell analysis from fluid samples. The goal is to find a non-invasive way to catch reje…

This study is testing a new test called the Enlighten Device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and follow them for three months after delivery…

This study tests a digital health program called weSIPsmarter to see if it helps reduce sugary drink consumption in preschool children and their parents. About 744 families from 12 rural Head Start programs will take part, with some programs using the program and others acting as…

This study tests whether semaglutide (a drug used for diabetes and weight loss) can prevent weight gain and fatty liver disease in people who have recently had a liver transplant. About 50 adults who had a transplant 2 to 6 months ago will receive either semaglutide or a placebo.…

This study tests whether well-timed text messages can help young Air Force trainees avoid binge drinking and its consequences. About 7,000 trainees will either get the standard alcohol intervention or that plus automated texts sent just before, during, and after they first get ac…

This early-phase trial at the University of Virginia is testing whether psilocybin (the active ingredient in magic mushrooms) can help people with prolonged grief disorder. Twelve adults aged 18-65 with complicated grief will receive a single 25 mg dose of psilocybin along with t…

This study tests whether an online insomnia treatment, followed by either a meditation program or pain education, can reduce pain in adults with chronic low back pain and insomnia. About 300 participants will first complete a 9-week internet-based cognitive behavioral therapy for…

This study looks at whether short-term beetroot juice (a source of nitrate) can improve blood vessel function, insulin sensitivity, and exercise ability in adults with prediabetes. Researchers will compare people who take metformin with those who do not. The goal is to find simpl…

This study tests whether a single dose of methadone given during brain surgery can control pain and improve recovery better than the usual short-acting opioid remifentanil. About 40 adults having elective brain surgery will be randomly assigned to receive one of the two medicines…

This early-stage study tests a non-invasive procedure that uses focused ultrasound to create a tiny lesion in the brain's pain center. It is for 20 adults with head, neck, or brachial cancer whose pain is not controlled by opioids. The goal is to see if it is safe and can reduce …

This study tests whether a simple wooden block stretching routine can replace standard physical therapy for people recovering from ankle or pilon fracture surgery. About 30 adults aged 18-65 who had surgery for these fractures will be randomly assigned to either the wooden block …

This study tests a mobile app designed to help people with Huntington's or Parkinson's disease feel less anxious by changing how they interpret everyday situations. Researchers will enroll 136 participants who have anxiety symptoms. The goal is to see if the app can improve quali…

This study looks at whether taking melatonin can improve sleep for resident doctors working night shifts. Fifty doctors will be randomly assigned to take melatonin or a placebo, and their sleep will be measured with a special monitor. The goal is to see if melatonin helps them ge…

This study tests whether offering a small cash payment to households can encourage more people to get screened for tuberculosis (TB) in rural Tanzania. Researchers will enroll 360 people recently diagnosed with TB and their families. Half will receive the usual care, and half wil…

This study looks at whether men with prostate cancer who have hot flashes from hormone therapy will consistently wear a smartwatch to track their symptoms. For 4 weeks, 18 participants will wear the watch, log hot flashes by pressing a button, and complete daily surveys. The goal…

This observational study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity in 70 adults with heart failure, peripheral artery disease, or overweight…

This study looks at why people with cystic fibrosis often develop kidney disease. Researchers will test blood and urine samples for early signs of kidney damage, comparing CF patients with and without frequent hospital stays, as well as people without CF. The goal is to find bett…

This study is testing a new imaging method called 4D-MRI that creates 3D movies of the lungs and liver as a person breathes. The goal is to help doctors better track tumor movement during radiation therapy, making treatment more precise. Researchers will test this in healthy volu…

This study looks at how to give weekly feedback to people trying to lose weight. About 127 adults who are overweight or obese will test different types of messages about their progress. The goal is to find which feedback helps people lose weight most effectively.

This study tests a fast genetic test done in the hospital to see if it helps doctors pick the best blood thinner for stroke patients. Some people have a gene variation that makes the common drug clopidogrel less effective. The test checks for 11 known gene variants and alerts the…

This study follows 120 teens aged 12–21 with obesity over two years. Half take a GLP-1 drug (like semaglutide) plus calcium and vitamin D; the other half use lifestyle changes only. Researchers measure bone density to see if the drugs affect bone strength. The goal is to understa…

This study looks at how being overweight affects insulin sensitivity and heart and muscle fitness in people with type 1 diabetes. Researchers will compare people with and without diabetes, before and after a high-intensity interval training program. The goal is to understand why …

This study compares two ways of providing pre-test education for cancer genetic testing: a chatbot (called GIA) versus a live genetic counselor. About 96 adults at high risk for certain cancers will be randomly assigned to one of the two methods. The main goal is to see if the ch…

This study checks if having a vaginal infection before vulvar surgery raises the risk of wound infections or breakdown. About 91 adults with non-cancerous vulvar conditions will be tested with a swab on surgery day. Researchers will follow up by phone at 1 week and a clinic visit…

This study looks at whether starting physical therapy early or later after a reverse shoulder replacement for a broken upper arm bone leads to better recovery. Ten adults aged 50 to 85 who have this surgery will be randomly assigned to either early or delayed rehab. The goal is t…

This study uses advanced MRI to measure the fat around the heart in people with a type of heart failure called HFpEF. Researchers want to see if the fat's composition, not just its amount, is linked to disease severity. They will also test if a diabetes drug called semaglutide ch…

This study looks at why people with chest pain but no blocked arteries (ANOCA) often have poor fitness. Researchers will test if a remote, high-intensity interval training (HIIT) program can safely improve heart function, exercise capacity, and quality of life. About 25 adults ag…

This study looks at how the meaning we find in music can change the way we feel pain. Researchers will ask 50 healthy adults to listen to music and report their pain sensations. They will also interview some participants to learn which parts of music are most meaningful and how t…

This study tests whether private Facebook groups can help pregnant women and new parents follow safe sleep guidelines and breastfeed longer. About 3,000 participants from WIC or with low income will join either a support group or a control group. The goal is to reduce the higher …

This study is for women aged 65 and older with early-stage, hormone-sensitive breast cancer. It tests whether taking hormone pills for 3 months before surgery helps patients feel more confident about skipping radiation after surgery. Half the participants will receive this pre-su…