University Of Virginia

This early-stage study tests a new treatment for a type of aggressive brain cancer called glioblastoma. The approach uses the patient's own immune cells, trained to attack the tumor, combined with low-intensity focused ultrasound to temporarily open the blood-brain barrier so the…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The treatment uses the patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Participants receive 8 infusions twice a wee…

This study tests whether a closed-loop artificial pancreas system can improve blood sugar control and reduce heart disease risk in 40 adults with type 1 diabetes. Participants will use a continuous glucose monitor and insulin pump that work together automatically. The researchers…

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can improve treatment outcomes. Researchers will enroll 200 adults and children with active, drug-sensitive tuberculosis in Tanzania. The goal is to see if personalized dosing helps m…

This study is for people with a rare type of blood cancer called peripheral T-cell lymphoma (PTCL) that has returned or not responded to prior therapy. It tests whether taking two drugs together (oral azacytidine and romidepsin) works better than taking one of several standard si…

This study tests an experimental drug called CIR-0602K in 40 adults with type 1 diabetes who already use an automated insulin pump. The goal is to see if the drug helps keep blood sugar in a healthy range longer and reduces the amount of insulin needed each day. Participants will…

This study tests different antibiotics to treat small intestine bacterial overgrowth (SIBO) in 60 malnourished children in Bangladesh. The goal is to find the best treatment to help children grow normally and avoid stunting. Participants must have a positive breath test for SIBO …

This study looks at whether natural estrogen given through a skin patch improves bone strength better than natural estrogen pills or a synthetic birth control patch in women aged 14-30 with functional hypothalamic amenorrhea (missing periods). Participants take estrogen for one y…

This study tests whether a pharmacist-led coaching program called QuitAid helps rural smokers in Appalachia quit cigarettes. About 768 participants will receive nicotine patches and may also get text support, phone counseling, or extra nicotine gum. The goal is to find the best c…

This early-phase study tests a new treatment for adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who still have small amounts of cancer cells after standard therapy. The treatment uses the patient's own blood cells that are specially prepared in the lab…

This study tests whether a blood test that tracks HPV DNA can help doctors safely give a lower dose of radiation to the neck in people with head and neck cancer. About 90 adults with oropharynx cancer will receive radiation tailored to their blood test results. The goal is to see…

This early-stage study tests a single dose of a lab-made clotting protein (recombinant von Willebrand factor) in 12 adults on ECMO who have severe bleeding. The goal is to see if the drug is safe and how it works in the body. ECMO patients often bleed because their natural clotti…

This study tests whether adding two doses of ketamine to the usual seizure medicine (levetiracetam) stops prolonged seizures (status epilepticus) more effectively than the medicine alone. About 770 people aged 1 year and older who are still seizing after first-line treatment will…

This study tests a mobile app designed to help people with Parkinson's or Huntington's disease feel less anxious. The app works by training users to interpret everyday situations in a less threatening way. Researchers will enroll 136 adults with anxiety symptoms to see if the app…

This early-phase study tests whether psilocybin-assisted therapy is feasible for people with prolonged grief disorder. Twelve adults aged 18-65 with severe grief symptoms will receive the treatment and be followed for 6 months. The main goals are to see if people join and stay in…

This study looks at whether adding a meditation program or pain education to standard sleep therapy can help reduce pain intensity in adults with chronic low back pain and insomnia. About 300 participants will receive cognitive behavioral therapy for insomnia, then be assigned to…

This early-stage study tests a new way to treat severe pain from head, neck, and brachial cancers when opioids no longer help. Using MRI-guided focused ultrasound, doctors create a small lesion in the brain's pain pathway to block pain signals. The study involves 20 adults aged 1…

This study looks at whether common vaginal infections (like yeast or bacterial vaginosis) increase the risk of wound problems after vulvar surgery for non-cancerous growths. About 91 adults will be tested with a simple swab before surgery, then checked one week and 4-6 weeks afte…

This study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity on a bike. The goal is to understand these connections in people with heart failure, ar…

This study looks at whether metformin, a drug used to lower blood sugar in people with type 2 diabetes, changes how well healthy young adults can exercise. Twenty people aged 18-30 will take metformin or a placebo and do several bike tests. The goal is to see if metformin reduces…

This study is for women aged 65 and older with early-stage, hormone-sensitive breast cancer. It tests whether taking hormone pills for 3 months before surgery helps patients and their doctors make a more informed decision about whether to skip radiation after surgery. Half the pa…

This study looks at two ways to provide genetic counseling before cancer genetic testing: with a human genetic counselor or with a chatbot called GIA. The goal is to see if the chatbot can help more people in rural areas decide to get tested. Participants will answer questions, p…