University Of Virginia

This study tests a treatment plan for men with aggressive prostate cancer that combines hormone therapy, external beam radiation, and a precise internal radiation implant. The goal is to see if this approach causes fewer side effects while still controlling the cancer. About 60 m…

This study tests a combination of specially trained immune cells (HER2 BATs) and the drug pembrolizumab in women with metastatic breast cancer that has spread. The goal is to find a safe dose and see if the treatment can shrink tumors. About 22 women will take part, first in a do…

This study looks at how being overweight or obese might make multiple sclerosis (MS) worse in children. Researchers will compare brain scans and blood tests from 58 kids with MS—half of normal weight and half overweight or obese—to see if obesity leads to more inflammation and br…

This study looks at whether a pharmacist-delivered smoking cessation program can work for low-income smokers who may or may not be ready to quit. About 100 adults from community health centers will receive nicotine replacement therapy and coaching. The goal is to see if the progr…

This study looks at whether a new heart medication (cardiac myosin inhibitor) improves tiny blood vessel function in people with hypertrophic cardiomyopathy (HCM). Researchers will measure blood flow in the heart muscle using special ultrasound images. The study involves 30 adult…

This study looks at why aortic stenosis (a narrowing of the heart's aortic valve) gets worse over time. Researchers want to see if certain blood markers and special ultrasound patterns can predict faster disease progression. The goal is to find new ways to slow the disease down. …