University Of Virginia

This early-phase study tests a new treatment for adults with acute myeloid leukemia or myelodysplastic syndrome who still have detectable cancer cells after standard therapy. The treatment uses the patient's own blood cells, which are armed with a special antibody to better targe…

This study tests whether a lower dose of radiation to the neck can safely control head and neck cancer. About 90 adults with oropharynx cancer will receive radiation guided by a blood test that tracks HPV DNA from the tumor. The goal is to reduce side effects while keeping the ca…

This study tests whether an artificial pancreas system can improve blood sugar control and, in turn, reduce heart disease risk in people with type 1 diabetes. The system combines an insulin pump with a continuous glucose monitor to mimic a healthy pancreas. Researchers will measu…

This study tests an experimental treatment for adults with advanced melanoma who are already getting immunotherapy and planning surgery. The treatment combines focused ultrasound (using sound waves to heat and destroy tumor tissue) with an injection of a drug called polyICLC that…

This early-stage study tests a single dose of a lab-made clotting protein (recombinant von Willebrand factor) in 12 adults on ECMO who have serious bleeding. The goal is to see if the drug is safe and how the body processes it. ECMO patients often bleed because the machine damage…

This study is testing whether the BCG vaccine, originally developed for tuberculosis, can be safely used to treat Mycobacterium avium complex (MAC) lung disease. About 48 adults with MAC lung disease will receive either a BCG injection or a placebo. Researchers will track side ef…

This study tests a digital health program called weSIPsmarter designed to help preschool children and their parents drink fewer sugary drinks. About 744 families from 12 rural Head Start programs will take part, with some using the program and others continuing as usual. The goal…

This study tests an experimental drug called CIR-0602K in 40 adults with type 1 diabetes who already use an automated insulin pump. The goal is to see if the drug helps keep blood sugar in a healthy range longer and reduces the amount of insulin needed each day. Participants will…

This study tests a pharmacist-led program called QuitAid to help rural smokers in Appalachia quit. About 768 participants will receive nicotine patches and may also get extra support like text messages, phone coaching, or longer medication. The goal is to see which combination wo…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The treatment uses the patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Participants receive these cells through an …

This study tests whether giving two common heart medications (a beta blocker and an ACE inhibitor) before and during strong chemotherapy can prevent heart damage in people with newly diagnosed acute myeloid leukemia (AML). About 70 adults will be randomly assigned to receive the …

This study tests if a combination of two drugs (romidepsin and oral azacytidine) works better than standard single drugs for people with peripheral T-cell lymphoma (PTCL) that has returned or not responded to prior therapy. About 50 adults will be randomly assigned to either the …

This study tests different antibiotics to treat small intestine bacterial overgrowth (SIBO) in 60 malnourished Bangladeshi children. The goal is to find the best treatment to help them grow normally and avoid stunting. Children must have a positive breath test for SIBO and be at …

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can help more people reach effective drug levels in their blood. The goal is to improve treatment success and reduce the risk of drug resistance. The trial involves 200 adults and chi…

This study looks at whether natural estrogen given through a skin patch improves bone strength more than natural estrogen pills or a synthetic birth control patch in women aged 14–30 with functional hypothalamic amenorrhea (missed periods due to stress, low weight, or exercise). …

This study tests whether giving two doses of ketamine along with the standard drug levetiracetam stops prolonged seizures (status epilepticus) better than levetiracetam alone. About 770 people aged 1 year and older who are still seizing after first-line treatment will take part. …

This early-stage trial tests a new treatment for a fast-growing brain cancer called glioblastoma. It combines special immune cells (EGFR BATs) with low-intensity focused ultrasound to temporarily open the blood-brain barrier, allowing more treatment to reach the tumor. The study …

This study looks at whether exercise, a medication called liraglutide, or both can improve blood flow to the heart and muscles and help the body use insulin better in adults with metabolic syndrome. About 80 people will be placed into one of four groups: control, exercise only, l…

This study aims to validate a blood test that may predict a woman's risk of developing postpartum depression (PPD) after childbirth. Researchers will enroll up to 500 pregnant women, collect a blood sample in the third trimester, and then follow them for 6 months after delivery t…

This study tests a special MRI scan that uses inhaled gas to detect early signs of rejection in lung transplant patients. Researchers will compare MRI results with genetic tests from lung fluid to improve early diagnosis. The goal is to catch rejection sooner and help more patien…

This study is testing a new test called the Enlighten Device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and follow them for three months after delivery…

This study tests whether semaglutide (a drug used for diabetes and weight loss) can prevent weight gain and fatty liver disease in people who have recently had a liver transplant. About 50 adults who had a transplant 2 to 6 months ago will receive either semaglutide or a placebo.…

This study tests whether well-timed text messages can help young Air Force trainees avoid binge drinking and its consequences. About 7,000 trainees will either get the standard alcohol intervention or that plus automated texts sent just before, during, and after they first get ac…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with prolonged grief disorder when combined with therapy. It involves 12 adults aged 18-65 who have had intense grief for a long time. The main goal is to see if the study is practical,…

This early-stage study tests a non-invasive procedure that uses focused ultrasound to create a tiny lesion in the brain's pain center. It is for 20 adults with head, neck, or brachial cancer whose pain is not controlled by opioids. The goal is to see if it is safe and can reduce …

This study tests whether a single dose of methadone given during brain surgery can control pain and improve recovery better than the standard drug remifentanil. About 40 adults having elective brain surgery will take part. The goal is to see if methadone leads to less pain and op…

This study tests whether a simple wooden block stretching routine can replace standard physical therapy for people recovering from ankle or pilon fracture surgery. About 30 adults aged 18-65 who had surgery for these fractures will be randomly assigned to either the wooden block …

This study tests a mobile app designed to help people with Huntington's or Parkinson's disease feel less anxious by changing how they interpret everyday situations. Researchers will enroll 136 participants who have anxiety symptoms. The goal is to see if the app can improve quali…

This study looks at whether taking melatonin can improve sleep for resident doctors working night shifts. Fifty doctors will be randomly assigned to take melatonin or a placebo, and their sleep will be measured with a special monitor. The goal is to see if melatonin helps them ge…

This study looks at whether adding a meditation program or pain education to standard sleep therapy can help reduce pain in adults with chronic low back pain and insomnia. About 300 participants will receive cognitive behavioral therapy for insomnia, then be assigned to one of tw…

This study tests whether a diabetes drug (SGLT2 inhibitor) can improve blood flow in the tiny heart vessels of women who have chest pain but no blocked arteries. About 150 women will take either the drug or a placebo for 12 weeks and have heart scans and questionnaires. The goal …

This study looks at whether starting physical therapy early or later after a reverse shoulder replacement for a broken upper arm bone leads to better recovery. Ten adults aged 50 to 85 who have this surgery will be randomly assigned to either early or delayed rehab. The goal is t…

This study tests a fast genetic test in the hospital to see if it helps doctors pick the best blood thinner for stroke patients. Some people's DNA makes a common drug, clopidogrel, less effective. The test checks for these genetic differences so doctors can choose a different med…

This study uses advanced MRI to measure the fat around the heart in people with a type of heart failure called HFpEF. Researchers want to see if the fat's composition, not just its amount, is linked to disease severity. They will also test if a diabetes drug called semaglutide ch…

This study looks at whether short-term beetroot juice (a source of inorganic nitrate) can improve blood vessel function, insulin sensitivity, and exercise ability in people with prediabetes. Researchers will compare results between those taking metformin and those not. The goal i…

This study looks at how being overweight affects insulin sensitivity and heart/lung fitness in people with type 1 diabetes. Researchers will compare people with and without diabetes, before and after a high-intensity interval training program. The goal is to understand why some p…

This study aims to develop a new 4D-MRI technique that creates 3D movies of the lungs and liver during breathing. The goal is to help doctors better target tumors in cancer patients receiving radiation therapy, especially when tumors move with each breath. The study involves 100 …

This study looks at how your fitness level affects the bacteria in your mouth and the blood flow to your muscles. Researchers will collect mouth swabs, saliva, and have participants exercise on a bike to measure peak fitness. The goal is to understand these connections in people …

This study looks at why people with chest pain but no blocked arteries (ANOCA) often have poor fitness. Researchers will test if a remote, high-intensity interval training (HIIT) program can safely improve heart function, exercise capacity, and quality of life. About 25 adults ag…

This study looks at whether having a common vaginal infection (like bacterial vaginosis, trichomonas, or yeast) before vulvar surgery increases the chance of wound infections or breakdown. About 91 adults with non-cancerous vulvar conditions will be tested with a swab on surgery …

This study looks at how the meaning we find in music can change the way we feel pain. Researchers will ask 50 healthy adults to listen to music and report their pain sensations. They will also interview some participants to learn which parts of music are most meaningful and how t…

This study aims to find the most effective way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants lose more weight. The study involves 127 adults with overweight or obesity who will track thei…

This study looks at whether men with prostate cancer who get hot flashes from hormone therapy will wear a smartwatch to track their symptoms. For 4 weeks, participants log hot flashes on the watch and complete daily surveys. The goal is to see if the watch data matches survey rep…

This study compares two ways of providing pre-test education for cancer genetic testing: a chatbot (GIA) versus a human genetic counselor. About 96 adults at high risk for certain cancers will be randomly assigned to one of the two methods. The main goal is to see if using a chat…

This study aims to understand why people with cystic fibrosis (CF) often develop kidney disease. Researchers will collect blood and urine samples from 260 CF patients (both in and out of the hospital) and compare them to samples from people without CF. The goal is to find early w…

This study tests whether private Facebook groups can help pregnant women and new parents follow safe sleep guidelines and breastfeed longer. About 3,000 participants from WIC or with low income will join either a support group or a control group. The goal is to reduce the higher …

This study is for women aged 65 and older with early-stage, hormone-sensitive breast cancer. It tests whether taking hormone pills for 3 months before surgery helps patients feel more confident about skipping radiation after surgery. Half the participants will receive this pre-su…

This study looks at whether giving small cash payments can encourage more people in rural Tanzania to get screened for tuberculosis (TB). It will also study how malnutrition affects the risk of getting TB. The researchers will follow 360 people with TB and their household members…

This study compares bone health in 120 adolescents aged 12-21 with obesity who either take GLP-1 receptor agonist drugs (like semaglutide) or follow lifestyle changes for weight loss. Over 24 months, researchers will measure bone density and strength using scans and lab tests. Th…