University Of Virginia

This study tests whether a pharmacist-led coaching program (QuitAid) helps rural smokers in Appalachia quit. About 768 participants will receive nicotine patches and may also get text support, phone counseling, or extra nicotine gum. The goal is to see which combination works bes…

This study tests whether a blood test that tracks HPV DNA can help doctors safely give a lower dose of radiation to the neck in people with head and neck cancer. About 90 adults with oropharynx cancer will receive radiation tailored to their blood test results. The goal is to see…

This early-stage study tests a single dose of a lab-made clotting protein (recombinant von Willebrand factor) in 12 adults on ECMO who have severe bleeding. The goal is to see if the drug is safe and how it works in the body. ECMO patients often bleed because their natural clotti…

This study tests whether adding two doses of ketamine to the usual seizure medicine (levetiracetam) stops prolonged seizures (status epilepticus) more effectively than the medicine alone. About 770 people aged 1 year and older who are still seizing after first-line treatment will…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The treatment uses the patient's own blood cells, which are armed with a special antibody to target cancer cells. The goal is to see if this therapy is safe and can slow…

This study looks at 150 women aged 14–30 with functional hypothalamic amenorrhea (a condition where periods stop due to stress, low weight, or over-exercise). It compares three estrogen treatments—natural estrogen patch, natural estrogen pill, or a synthetic birth control patch—t…

This study tests whether measuring rifampin levels in urine can help doctors adjust doses for people with active tuberculosis (TB). The goal is to ensure each patient gets the right amount of medicine to kill the bacteria effectively. About 200 adults and children with drug-sensi…

This study is testing a mobile app that helps people with Parkinson's or Huntington's disease change how they think about everyday situations to feel less anxious. About 136 participants will use the app and report their anxiety levels. The goal is to see if this simple, at-home …

This early-stage study tests a new way to treat severe pain from head, neck, and brachial cancers when opioids no longer help. Using MRI-guided focused ultrasound, doctors create a small lesion in the brain's pain pathway to block pain signals. The study involves 20 adults aged 1…

This study looks at whether adding a meditation program or pain education to standard sleep therapy can help reduce pain intensity in adults with chronic low back pain and insomnia. About 300 participants will receive cognitive behavioral therapy for insomnia, then be assigned to…

This study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity in 70 adults with heart failure, artery disease, or overweight. The goal is to understa…