University Of Virginia

This study tests a new treatment for women with metastatic breast cancer that has spread. It combines specially trained immune cells (HER2 BATs) that attack cancer cells with a drug called pembrolizumab that helps the immune system work better. The goal is to find a safe dose and…

This study tests a treatment plan that adjusts chemotherapy based on a patient's fitness level for adults aged 60 and older with untreated classical Hodgkin lymphoma. All participants receive the immunotherapy drug pembrolizumab plus another targeted drug, then a PET scan and fit…

This study tests whether dulaglutide, a drug already used for type 2 diabetes, can improve blood vessel function in adults with type 1 diabetes. The goal is to see if it reduces damage to small blood vessels, which can lead to complications. About 47 people aged 18-40 with type 1…

This study tests a treatment plan for men with aggressive prostate cancer that combines hormone therapy, MRI-guided internal radiation implants, and external beam radiation. The goal is to see if this approach causes fewer side effects while still controlling the cancer. About 60…

This early-phase study tests a combination of three drugs (pembrolizumab, decitabine, and pralatrexate) in adults with relapsed or refractory peripheral or cutaneous T-cell lymphoma. The main goals are to find the safest dose and see if the treatment shrinks tumors. About 37 part…

This study is developing and testing a smartphone app designed for Native American women to help them avoid pregnancy affected by alcohol. Researchers will gather feedback and pilot test new features with 407 women who are at risk. The goal is to reduce risky drinking and improve…

This study looks at whether memantine, a drug already used for Alzheimer's symptoms, might help prevent the disease in people at high risk. Researchers are testing it in 32 adults aged 50 to 65 who have a family history of dementia and carry the ApoE4 gene. The main goal is to se…

This study tests a program called R-CITY that teaches students and teachers social skills like recognizing emotions and building resilience. The goal is to prevent violence and create safer classrooms. About 145 students and teachers from elementary and middle schools are taking …

This study looks at whether starting palliative care early can help adults with aggressive leukemias or myelodysplastic syndrome (MDS) have a better end-of-life experience. Researchers will compare where patients die (home, hospice, or hospital) and how often they need hospital c…

This study tests a smartphone app called Tremor Retrainer for people with functional tremor, a movement disorder not caused by other diseases. About 20 participants aged 10 and older will use the app and be monitored via video. The goal is to see if the app is easy to use and if …

This study looks at whether a pharmacist-led program can help low-income smokers use nicotine patches or lozenges to quit or smoke less. About 100 adults from community health centers will take part, including those not yet ready to quit. The goal is to see if the program is prac…

This study involves 30 adults with lung cancer who are taking oral targeted therapy. Participants use a smartphone app, a Fitbit, and a smart pill cap to track symptoms and medication use for up to 24 weeks. The goal is to see if this remote monitoring system is practical and can…

This study looks at whether metformin, a drug used for diabetes, changes how well healthy young adults can exercise. Fourteen people aged 18-30 will take metformin or a placebo and do bike tests to measure their endurance and blood lactate levels. The goal is to see if metformin …

This study aims to understand how the body's response to insulin changes during pregnancy in people with type 1 diabetes. Researchers will analyze data from continuous glucose monitors and insulin pumps used by 100 participants from before pregnancy to six months after birth. The…

This study was designed to see if women aged 40-49 with Polycystic Ovary Syndrome (PCOS) prefer metformin or birth control pills based on their quality of life. The goal was to compare how satisfied patients were with each treatment. However, the study was withdrawn before enroll…

This study looks at how being overweight or obese might make multiple sclerosis (MS) worse in children. Researchers will compare brain scans and blood tests from 58 kids with MS—half of normal weight and half overweight—to see if obesity leads to more inflammation and brain shrin…

This study looks at whether adults aged 65 and older with memory concerns can collect a small blood sample at home to check for Alzheimer's disease risk. Participants will use a simple device to draw blood, mail it to a lab, and get results from a doctor over video. The goal is t…

This study looks at 109 people in Virginia with nontuberculous mycobacterial (NTM) lung disease. Researchers use genetic sequencing to tell if a repeat infection is a relapse or a new infection from the environment. The goal is to better understand how the disease comes back and …

This study looks at whether a new heart medication (cardiac myosin inhibitor) can improve tiny blood vessel function in people with hypertrophic cardiomyopathy, a condition where the heart muscle is thickened. Researchers will use ultrasound to measure blood flow in the heart at …

This study looks at how certain blood components and heart imaging patterns might help predict the worsening of aortic stenosis, a common heart valve condition in older adults. Researchers will study 65 people with mild or moderate aortic stenosis and compare them to healthy cont…