Can a new heart drug improve blood flow in thick heart muscle?
NCT ID NCT06599229
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a new type of heart medication, called a cardiac myosin inhibitor, can improve blood flow in the small blood vessels of the heart in people with hypertrophic cardiomyopathy (HCM). Researchers will use special ultrasound imaging to measure blood flow before and after starting the medication. The study involves 30 participants who are already planning to take this medication as part of their regular care.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with HCM who are being started on cardiac myosin inhibitor therapy.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of hypertrophic cardiomyopathy * Subject being initiated on clinically-indicated cardiac myosin inhibitor therapy Exclusion Criteria: * Pregnancy * Lactation * Allergy to ultrasound enhancing agent (lipid-stabilized) or regadenoson * Serious AE to regadenoson * Hypotension * Serious bradycardia not addressed by pacemaker * Moderate or greater reactive airways disease
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Virginia
Charlottesville, Virginia, 22903, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- 3,000 hearts, one goal: mapping how hypertrophic cardiomyopathy unfolds in china
- Heart scan AI could predict sudden cardiac death risk in common heart condition
- Experimental pill aims to ease thick heart muscle symptoms
- Massive HCM database aims to unlock better heart care
- Heart drug swap tested for safer symptom control
- Real-World HCM drug use under the microscope