HYPERTROPHIC CARDIOMYOPATHY (HCM)

This study looks at whether patients with a thickened heart muscle condition can safely switch from one medication (mavacamten) to a newer one (aficamten). About 40 adults currently taking mavacamten will be monitored for side effects and heart function changes. The goal is to se…

This study tests a special PET/CT scan using a new tracer called [68Ga]Ga-NI-FAPI-04 to better see diseases linked to fibroblast activation, such as tumors, heart problems, lung scarring, and immune conditions. About 30 adults, including healthy volunteers, will get the scan to s…

This study uses artificial intelligence to analyze standard EKG results, aiming to more accurately diagnose hypertrophic cardiomyopathy (a thickened heart muscle) and tell it apart from other conditions that look similar. Researchers will enroll 15,000 adults, including those wit…

This study is building a secure database of health information from 2,500 people with hypertrophic cardiomyopathy (HCM), an inherited condition that thickens the heart muscle. Researchers will collect routine medical data like heart scans, blood tests, and genetic information ove…

This study will use advanced MRI scans to measure heart tissue in 2000 adults with different heart conditions. The goal is to create a reference guide for doctors to interpret these scans more easily, and to see if a simpler scan without contrast dye can be used for diagnosis. Pa…

This study looks back at medical records of 100 children with a rare genetic condition called RASopathy that causes severe heart thickening and heart failure. The goal is to collect detailed health and genetic information to create a comparison group for future drug trials. No ne…

This study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns for different heart conditions, like cardiomyopathy and heart transplant recovery. The goal is to improve how doctors diagn…

This study follows up on people with hypertrophic cardiomyopathy (HCM), a genetic condition that thickens the heart muscle and can lead to dangerous heart rhythms or heart failure. Researchers want to see if a substance called Gadolinium, which shows up on heart MRI scans, can pr…