HYPERTROPHIC CARDIOMYOPATHY (HCM)
Clinical trials for HYPERTROPHIC CARDIOMYOPATHY (HCM) explained in plain language.
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Heart drug mavacamten targets rare blockage in thick heart muscle
Disease control Not yet recruitingThis study tests the drug mavacamten in 132 people with hypertrophic cardiomyopathy (thick heart muscle) that blocks blood flow in the middle to lower part of the heart. The goal is to see if the drug reduces the pressure buildup in the heart during a breathing maneuver over 36 w…
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Phase: PHASE4 • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated May 22, 2026 14:05 UTC
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Blood thinner may prevent stroke in heart muscle disease patients
Prevention Not yet recruitingThis study tests whether the blood thinner rivaroxaban can prevent strokes in people with hypertrophic cardiomyopathy (HCM) who have early signs of heart strain but no irregular heartbeat. About 532 adults aged 40-80 with HCM and abnormal left atrial strain will be randomly assig…
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Phase: PHASE3 • Sponsor: Rennes University Hospital • Aim: Prevention
Last updated May 26, 2026 09:46 UTC
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Gene test could personalize heart drug treatment
Knowledge-focused Not yet recruitingThis study looks at why the heart drug mavacamten works better for some people with hypertrophic cardiomyopathy (a condition where the heart muscle thickens). Researchers will check if a person's specific gene causing HCM and their natural ability to process medications (via the …
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Sponsor: University of Manchester • Aim: Knowledge-focused
Last updated May 26, 2026 09:28 UTC
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Heart rhythm mystery: study targets AF in thickened hearts
Knowledge-focused Not yet recruitingThis study looks at why people with hypertrophic cardiomyopathy (thickened heart muscle) often develop atrial fibrillation (an irregular heartbeat) and why standard treatments may not work as well for them. Researchers will study electrical signals and images of the heart in 40 a…
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Sponsor: Guy's and St Thomas' NHS Foundation Trust • Aim: Knowledge-focused
Last updated May 22, 2026 13:50 UTC
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Heart energy boost: new MRI study tests Drug's hidden power
Knowledge-focused Not yet recruitingThis study looks at whether a new medication (mavacamten) can improve the energy levels of heart muscle in people with obstructive hypertrophic cardiomyopathy, a condition where the heart muscle thickens and blocks blood flow. Researchers will use a special MRI scan to measure th…
Matched conditions: HYPERTROPHIC CARDIOMYOPATHY (HCM)
Sponsor: University of Manchester • Aim: Knowledge-focused
Last updated May 04, 2026 16:22 UTC