University Of Virginia

This study compared two treatments for bleeding after heart surgery in children aged 2 years or younger. One group received a purified fibrinogen concentrate, the other received cryoprecipitate (a blood product). The goal was to see if the concentrate works as well as cryoprecipi…

This pilot study tested a new algorithm that uses continuous glucose monitor (CGM) data to automatically adjust long-acting insulin doses in people with type 2 diabetes. Thirty participants were followed for 18 weeks to see if the algorithm improved blood sugar control compared t…

This study looked at how well an artificial pancreas system (the Tandem t:slim pump with Control-IQ Technology) works for teenagers with Type 1 Diabetes during puberty. It followed 42 adolescents aged 11-13 for two years, comparing the device to usual care. The goal was to see if…

This study tested whether topiramate, a seizure medication, helps people who are dependent on both alcohol and nicotine. 236 adults took either a high or low dose of topiramate or a placebo for 18 weeks. The main goals were to see if the drug helped them stop smoking and reduce h…

This pilot study tested whether using an automated insulin delivery (AID) system for just 10 days can help people with type 2 diabetes safely adjust their long-acting insulin doses. 23 adults who already used insulin injections took part. The goal was to see if the device was saf…

This study tested a continuous glucose monitor (CGM)-based advisory system to help adults with type 1 diabetes better manage their blood sugar. The system gives personalized advice based on glucose readings and the person's behavior and mindset. The goal was to improve glucose co…

This small study tested a new tool called InsuLearn that helps people with type 1 diabetes calculate their insulin doses without needing to count carbohydrates. Seven adults on multiple daily injections used the tool for a day and were compared to their usual care. The goal was t…

This pilot study tested whether a smartphone app can accurately measure gaze stability and the vestibulo-ocular reflex (VOR) in adults with and without balance disorders. 35 participants performed standard balance tests using both a smartphone app and a commercial computer system…

This study tested a 45-minute classroom program called UP2UTobacco for 9th graders. The goal was to help students quit or avoid tobacco and nicotine products, including e-cigarettes. Nearly 600 students took part, and researchers checked if the program led to more teens being tob…

This study tested whether a mobile app called IntelliCare can reduce depression and anxiety in breast cancer survivors. 313 women who had been diagnosed within the past 5 years and had elevated symptoms used the app or received standard educational materials. The study also looke…

This study tested a program called iSIPsmarter, which uses text messages and online tools to help adults in rural Appalachia drink fewer sugary beverages like soda and sweet tea. About 249 adults who drank at least 200 calories of sugary drinks daily took part. The program was co…

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and boost well-being in breast cancer survivors. Researchers enrolled 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild to moderate a…

This study tested a telephone helpline designed to support people with opioid dependence. The helpline offered education, coping strategies, and referrals to medication-assisted treatment. Researchers enrolled 31 participants and measured satisfaction with the service. The goal w…

This study looked at whether donepezil (Aricept), a drug that boosts a brain chemical called acetylcholine, can help improve walking and balance in people with Parkinson's disease. Six participants took the drug for 12 weeks while researchers measured their walking speed and brai…

This study tested whether low-intensity focused ultrasound (LIFU) can safely reduce cravings in people with cocaine use disorder. 25 adults received either real or fake (sham) ultrasound while their brain activity was measured with MRI. The goal was to see if LIFU lowers craving …

This completed study from the University of Virginia looked at whether having a hiatal hernia (a stomach issue) is linked to early, undetected lung scarring. Researchers collected blood and lung fluid samples from 14 adults before surgery to measure signs of lung injury. The goal…

This study looked at how different exercise intensities change levels of ghrelin, a hormone that controls hunger, in 40 adults with obesity and prediabetes. Participants exercised on a stationary bike, and researchers measured ghrelin, appetite, and blood vessel function. The goa…

This study used a special MRI technique with inhaled helium to measure how fast air moves through the windpipe. Researchers compared 24 healthy volunteers and people with COPD or constrictive bronchitis. The goal was to gather real data to improve computer models that predict air…

This study tested a new way to measure muscle stiffness by taking pictures of the skin on the back. Five adults, either healthy or with mild neck pain, had their skin gently pulled and stretched while cameras recorded the movement. The goal was to see if this simple imaging metho…

This study tested how a pill called 2DG, which is similar to sugar but can't be used for energy, is processed by the body in 9 adults with epilepsy. The idea is that 2DG might stop seizures by blocking the brain's fuel supply during a seizure. Researchers measured drug levels in …

This pilot study tested whether computer models could predict sepsis and necrotizing enterocolitis (NEC) in very low birth weight infants (under 1500 grams). Researchers used existing NICU data to build and test these models. The goal was to see if this approach is feasible, not …

This study tested a group-based program to help endometrial cancer survivors adopt healthier habits. The goal was to lower their risk of other health problems like heart disease and diabetes. Twenty-three survivors who had finished cancer treatment took part in online learning an…