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Glow-in-the-Dark dye could help surgeons spot hidden cancer cells

NCT ID NCT07460765

First seen Apr 07, 2026 · Last updated Jun 23, 2026 · Updated 10 times

Summary

This early-stage trial tests a fluorescent dye attached to the cancer drug nivolumab. The dye is meant to make cancer cells glow during surgery, helping surgeons remove them more precisely. The study will enroll 40 people with head and neck cancer who are already scheduled for surgery. The main goal is to check if the dye is safe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

nivolumab with a fluorescent dye (IRDye800CW)

What this could lead to

If successful, this could help surgeons see cancer cells more clearly during surgery, potentially leading to more complete tumor removal.

What could go wrong

This is a very early phase 1 safety study with only 40 people. The dye may not work as hoped, and there could be side effects from the drug or the dye.

Conditions

The condition(s) this trial relates to.

head and neck carcinoma Head and Neck Neoplasms head and neck squamous cell carcinoma Mouth Neoplasms oral cavity squamous cell carcinoma squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck squamous cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.