Otorhinolaryngologic disease

This study looked at whether using antibiotic ear drops during and after ear tube surgery reduces the chance of tube blockage or ear drainage in children. Only 9 children took part, and each child received drops in one ear but not the other. The study was stopped early, so the fi…

This Phase 3 trial tests whether adding an experimental immunotherapy called PDS0101 to the standard drug pembrolizumab helps people with advanced HPV16-positive head and neck cancer live longer. About 252 participants will receive either the combination or pembrolizumab alone. T…

This trial tests whether the antiviral drug valganciclovir can improve hearing and language outcomes in infants who have hearing loss due to congenital cytomegalovirus (CMV) infection. Infants aged 1 to 12 months with confirmed sensorineural hearing loss will receive either valga…

This early study tested a new cell therapy called LUCAR-G79 in just 3 adults with severe autoimmune diseases that did not respond to standard treatments. The therapy uses specially engineered immune cells to target and potentially calm the overactive immune system. The main goals…

This study looked at whether treating the dental cause of chronic maxillary sinusitis with dental procedures and medication could resolve symptoms. Only 16 patients were enrolled before the study was terminated. The main goal was to see if symptoms disappeared and pus cleared fro…

This study tested whether injecting vidutolimod directly into tumors plus giving cemiplimab through a vein could shrink cancers that have spread. The trial included 77 people with several types of advanced cancer. Unfortunately, the study was stopped early, so we have less inform…

This early-phase trial tested combinations of the drugs bevacizumab and temsirolimus, sometimes with valproic acid or cetuximab, in 154 people with advanced cancers or certain non-cancerous but progressive diseases. The main goal was to find safe doses and look for any signs that…

This study looked at the best way to treat a tonsillar abscess, a painful infection near the tonsils. It compared two treatments: removing the tonsils (tonsillectomy) versus draining the pus with a needle under local anesthesia. The goal was to see which method works better to cl…

This study looked at adding two immunotherapy drugs (ipilimumab and nivolumab) to standard radiation for people with advanced HPV-positive throat cancer. The goal was to see if the combination was safe and could shrink tumors better than radiation alone. The trial enrolled 37 par…

This small, early-stage trial tested a combination of a steroid spray (triamcinolone) and a decongestant spray (oxymetazoline) to help people who were dependent on decongestants stop using them. The study planned to slowly reduce the decongestant dose while keeping the steroid st…

This early-phase study tested a treatment using donated natural killer (NK) cells from cord blood, combined with chemotherapy, for children and young adults with solid tumors that returned or didn't respond to standard care. The goal was to find the safest dose and check for side…

This study tested a drug called PRO1160 in people with advanced kidney cancer, nasopharyngeal cancer, or non-Hodgkin lymphoma. The goal was to find a safe dose and see if the drug shrinks tumors. The trial was stopped early, so results are limited.

This phase 3 study tested the drug benralizumab in 295 adults with severe nasal polyps and eosinophilic chronic sinusitis. Participants received injections of benralizumab or a placebo every 4 to 8 weeks for about a year. The goal was to see if the drug could shrink polyps and im…

This study tested an experimental drug called vobramitamab duocarmazine in people with advanced prostate cancer and other solid tumors that stopped responding to standard treatments. The goal was to see if the drug could shrink tumors or slow cancer growth. The trial was terminat…

This study tested whether metformin (a diabetes drug) and doxycycline (an antibiotic) could help treat head and neck cancer when taken before surgery. The trial aimed to see if these drugs could change certain proteins in the tumor's supportive tissue. Only 7 people took part bef…

This early-phase trial tested an experimental drug called TAK-500, alone or with the immunotherapy pembrolizumab, in 61 adults with advanced solid tumors like pancreatic, liver, and lung cancer. The main goals were to check safety and see if the drug could shrink tumors. The stud…

This early-stage trial tested a combination of two drugs, APG-1387 and toripalimab, in 40 people with advanced solid tumors including colorectal, nasopharyngeal, and lung cancers. The goal was to find a safe dose and see if the combination could control the disease. However, the …

This study tested a peptide-based immunotherapy in 17 people with head and neck cancer who were scheduled for surgery. The goal was to see if the vaccine could boost the immune system's attack on cancer cells and to check for side effects. The trial was stopped early, but the res…

This study tested a device called the SPIRION Laryngeal Pacemaker in 10 people with bilateral vocal cord paralysis who had prior vocal fold surgery. The device is implanted to help open the vocal cords during breathing. Researchers checked if it was safe and if it improved breath…

This study followed one person with microtia (a small or missing outer ear) who had already received an AUR-201 implant — a 3D-printed ear made from their own cartilage cells. Researchers checked how well the implant kept its shape and whether any side effects appeared up to 96 w…

This trial tested a new ear implant called AUR-201 for people with a rare birth defect called microtia, where one ear is small or missing. The implant was custom-made using the patient's own cartilage cells and a 3D-printed scaffold. Only 3 people were enrolled before the study w…

This study tested an experimental implant called AUR-201 to rebuild the outer ear in people with unilateral microtia (one ear that is small or missing). Only 2 people enrolled before the study was stopped early. The goal was to check safety and see if the implant improved ear app…

This early-phase trial tested a new drug called INCB062079 in 25 people with advanced liver cancer and other solid tumors. The main goal was to check safety and find the best dose. The study was terminated early, so results are limited.

This early-stage study tested an experimental drug called INCB099318 in people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check the drug's safety and how the body processes it. The study was terminated early, so results are…

This study looked at whether adding the immunotherapy drug nivolumab to standard chemotherapy could help people with nasopharyngeal cancer that has returned or spread. The trial was planned for many participants but was stopped early, so only 15 people took part. Because of the e…

This study tested a dye called tozuleristide that makes oral cancer cells glow under special light during surgery. The goal was to help surgeons see and remove all cancer while sparing healthy tissue. The trial included 8 adults with oral cavity cancer or high-grade dysplasia. Th…

This study tested whether a special imaging technique called narrow band imaging (NBI) can help surgeons find early cancer spots in the mouth that are not visible under normal light. The trial involved 23 people with oral cancer who were already scheduled for surgery. Doctors com…

This trial tests whether adding lidocaine ear drops to standard painkillers provides better ear pain relief for children aged 1–6 with acute otitis media. Half the children receive the ear drops plus usual care (oral painkillers, with or without antibiotics), while the other half…

This study tests a new sedative called remimazolam for people in the ICU who need a breathing tube after oral or facial surgery. It compares remimazolam to two standard sedatives, propofol and midazolam, to see if it works just as well and helps patients wake up faster. The trial…

This study compared a newer, less invasive procedure called balloon sinuplasty to standard surgery for people with frontal sinusitis that did not improve with medication. The balloon procedure uses a small catheter to open blocked sinus passages, aiming to reduce pain, bleeding, …

This study tested a redesigned lacrimal stent, called the Slit Stent II, for people with severe tearing (epiphora) caused by a blocked tear duct. The stent has slits to allow tears to drain while it is still in place after DCR surgery. The trial planned to enroll 5 people to chec…

This study tested whether teaching teens and young adults (ages 14-29) the correct way to use nasal sprays for hay fever would improve their symptoms compared to standard care. The trial was terminated early and enrolled only 18 participants. The goal was to see if repeat educati…

This study tested whether using the SinuSonic device—a handheld tool that uses sound and gentle pressure to relieve nasal congestion—could also improve anxiety, depression, and overall well-being in adults with chronic stuffy nose. Sixteen participants used the device for 5 weeks…

This study aimed to find the best amount of exercise needed to improve dizziness symptoms in people with balance disorders. Researchers used virtual reality (VR) to measure how much exercise helps and compared VR exercises to standard physical therapy. The study included people w…

This very early trial tested a single dose of HB-201 in 10 people with HPV 16+ throat or cervical cancer. The goal was to see how the drug affects the immune system, not to treat the cancer. The study was terminated early, so results are limited.

This study aimed to track lung function in children born prematurely (before 37 weeks) aged 3 to 5 years, comparing them to full-term children. Researchers used breathing tests and samples to look for early signs of asthma and allergies. The study was terminated early, so results…

This study looked at why people with mouth or throat cancer wait before seeing a doctor. Researchers interviewed 90 patients and asked them to fill out questionnaires about their feelings, thoughts, and social situation. The goal was to understand what factors cause the delay, so…

This study looked at whether people born with cytomegalovirus (CMV) infection who have hearing loss or balance problems also have a condition called endolymphatic hydrops (fluid buildup in the inner ear). Researchers used a special MRI scan with a contrast dye to check for this f…

This study tested a new planning method to protect areas where dental implants could later be placed in patients receiving radiation for head and neck cancer. Researchers used virtual implant markers on CT scans to adjust radiation doses, aiming to keep implant sites safe without…