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Cancer drug combo study halted early – only 15 patients enrolled

NCT ID NCT04458909

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding the immunotherapy drug nivolumab to standard chemotherapy could help people with nasopharyngeal cancer that has returned or spread. The trial was planned for many participants but was stopped early, so only 15 people took part. Because of the early closure, we don't have clear results on whether the combination works better than chemo alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

15 people

The number who actually took part.

Started

Dec 2020

Finished

Aug 2023

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pathologically (histologically or cytologically) proven diagnosis of NPC that has recurred at locoregional and/or distant sites. For locoregional recurrence, the disease must not be amenable to potentially curative surgery or re-irradiation. The following histological types are accepted: (a) Keratinizing - squamous cell carcinoma; (b) Non-keratinizing - undifferentiated or poorly differentiated * Measurable disease by the RECIST 1.1 criteria. Lesion(s) that have been irradiated previously can be counted as measurable as long as radiological progression has been demonstrated prior to enrollment * History/physical examination by a medical oncologist or clinical oncologist within 14 days prior to registration * Zubrod/Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 within 14 days prior to registration * Contrast enhanced magnetic resonance imaging (MRI) or computed tomography (CT) of the nasopharynx and neck within 30 days prior to registration * Contrast enhanced CT scan of the chest, abdomen, and pelvis within 30 days prior to registration * Absolute neutrophil count (ANC) \>= 1500 cells/mm\^3 (within 14 days prior to registration) * Platelets \>= 100,000 cells/mm\^3 (within 14 days prior to registration) * Hemoglobin \>= 9.0 g/dL (transfusion is accepted. Erythropoietin dependency not accepted) (within 14 days prior to registration) * Total bilirubin =\< 1.5 x upper limit of normal (ULN) OR direct bilirubin =\< ULN for patients with total bilirubin levels \> 1.5 x ULN. Patients with known Gilbert's syndrome are not excluded (within 14 days prior to registration) * Alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x ULN (=\< 3 x ULN for patients with liver metastases) (within 14 days prior to registration) * Serum creatinine =\< 1.5 x ULN OR calculated creatinine clearance (CrCl) based on Cockcroft-Gault equation \>= 30 mL/min for patients with serum creatinine levels \> 1.5 x ULN. In this protocol, cisplatin or carboplatin may be used at the discretion of the investigator - except for patients with CrCl between 30-50 mL/min, for whom carboplatin should be used instead of cisplatin (within 14 days prior to registration) * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable, and patients must be receiving anti-viral therapy at enrollment. Patients must agree to continue anti-viral therapy throughout the study period as directed by their treating physicians * Known positive test for hepatitis B virus surface antigen (HBsAg) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on anti-viral therapy * Patients who are immune to hepatitis B (anti-Hepatitis B surface antibody positive) are eligible (i.e., patients immunized against hepatitis B) * In some centers, hepatitis B core antibody (anti-HBc) is done routinely before chemotherapy for some cancer patients. This is because patients who are HBsAg-negative but positive for anti-HBc should have undetectable HBV viral load at enrollment and receive prophylactic anti-viral therapy throughout the study (American Society of Clinical Oncology 2015 guideline, Hwang 2015). In this protocol, anti-HBc should be performed based on institutional standards * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment they are eligible if they have an undetectable HCV viral load * Note: Known positive test for hepatitis C virus ribonucleic acid (HCV RNA) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy * For women of childbearing potential (WOCBP), negative serum or urine pregnancy test within 14 days prior to registration. For WOCBP randomized to Arm 1, an additional negative serum or urine pregnancy is required within 24 hours prior to starting nivolumab treatment * Women of childbearing potential (WOCBP) is defined as any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal. Menopause is defined clinically as 12 months of amenorrhea in a woman over 45 in the absence of other biological or physiological causes * Women of childbearing potential (WOCBP) and men who are sexually active with WOCBP must be willing to use an adequate method of contraception. Women must use an effective oral contraception and the male partner must use condom) during and after treatment * The patient or a legally authorized representative must provide written informed consent prior to study entry Exclusion Criteria: * Diagnosed with another invasive malignancy (except non-melanomatous skin cancer) unless disease free for more than 3 years. Note: Patients with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g. breast carcinoma, cervical cancer in situ) who have undergone potentially curative therapy are not excluded * Any prior systemic anti-cancer agents (including chemotherapy and investigational agents) for the purpose of treating locoregional and/or distant recurrence of NPC * Patients who have received neoadjuvant (induction) and/or adjuvant chemotherapy for primary NPC with chemotherapy (any drug regimens including those containing platinum and/or gemcitabine) at or within 6 months prior to registration are excluded (counting from the last day of the chemotherapy for the primary NPC, prior to enrolling into the current study). The following subgroups of patients are NOT excluded: * Patients who have received neoadjuvant (induction) and/or adjuvant chemotherapy for primary (non-metastatic/non-recurrent) NPC more than 6 months prior to registration, counting from the last day of the chemoradiotherapy for the primary NPC, prior to enrolling into the current study * For prior RT with radical intent: Patients who have prior radiotherapy (RT) to the primary and locoregional disease (i.e. non-recurrent disease) with or without concurrent cisplatin or carboplatin monotherapy are not excluded as long as they have not received any neoadjuvant/adjuvant chemotherapy within 6 months prior to registration (counting from the last day of the chemotherapy), and that the last RT fraction (with radical intent) has been given more than 3 months prior to registration * For RT with palliative intent: Prior radiotherapy (RT) at or within 30 days prior to registration, this includes RT given with palliative intent (with or without concurrent cisplatin or carboplatin alone) to recurrent/ metastatic sites in patients with recurrent/metastatic NPC. The re-irradiated sites must not be the only sites of measurable recurrent disease * Prior chemotherapy for cancers other than NPC is allowed as long as the last course of chemotherapy was administered more than 3 years prior to registration and the patient has remained disease-free for more than 3 years * Prior therapy for any indication, with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g. CTLA-4, OX-40, CD137) * History of severe (grade 3-4) hypersensitivity reaction to any monoclonal antibody including nivolumab and/or any of its excipients * Severe, active co-morbidity defined as follows: * Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months * Myocardial infarction within the last 6 months * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration * Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days of registration * Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects * History of (non-infectious) pneumonitis that required steroids or has current pneumonitis requiring steroids and/or immunosuppressive therapy * History of active TB (Bacillus tuberculosis, not known to be multi-drug resistant) as defined by the need to receive systemic treatment within the last 2 years or any known history of multi-drug resistant TB. Note: Patients who had a distant history of treated TB (not known to be multi-drug resistant) at 5 or more years from enrollment and have no current symptoms suggestive of active TB, are not excluded from this study. Note: Testing for prior exposure to TB is not required in this study since TB is endemic in parts of Asia * Prior solid organ transplant or bone marrow transplant * History of active primary immunodeficiency including, but not limited to acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; Note: Human immunodeficient virus (HIV) testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is necessary because the treatment involved in this protocol may be immunosuppressive * Condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone or equivalents) or other immunosuppressive medications within 14 days of registration. Inhaled or topical steroids and adrenal replacement doses \< 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. Steroid premedication for the prophylaxis of CT contrast-related allergies is allowed. The use of dexamethasone as an anti-emetic premedication prior to chemotherapy is also allowed * Active autoimmune disease requiring systemic treatment (i.e. disease modifying agents, corticosteroids, or immunosuppressive drugs) within the past 2 years. These include but are not limited to patients with a history of immune-related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), rheumatoid arthritis, connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease * Note: Patients are permitted to enroll if they have vitiligo; type I diabetes mellitus; hypothyroidism, pituitary or adrenal insufficiency requiring only hormone replacement; psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event) * Patients who are pregnant or breastfeeding and unwilling to discontinue breastfeeding * Known history of grade 3-4 allergic reaction and/or hepatic toxicity to cisplatin, carboplatin, or gemcitabine * Note: For patients with known history of grade 3-4 renal toxicity to cisplatin or known history of clinically significant hearing loss (grade 2 or above) attributed to cisplatin, or other intolerances to cisplatin that are of clinical significance, carboplatin can be used in this study and therefore these patients are NOT excluded from enrollment * Known central nervous system (CNS) metastases and/or carcinomatous meningitis. Patients with base of skull involvement by NPC are not excluded unless their disease is directly invading the brain parenchyma and is associated with clinical symptoms (headaches, nausea and vomiting, neurological abnormalities on physical examination) and/or cerebral edema on radiological imaging * Patients who have received a live vaccine within 30 days prior to the first dose of study treatment. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines and are not allowed * History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of the subject to participate, in the opinion of the treating investigator

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Conditions

The condition(s) this trial relates to.

nasopharyngeal carcinoma nasopharyngeal squamous cell carcinoma undifferentiated carcinoma of nasopharynx

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metastatic nasopharyngeal carcinoma Metastatic nasopharyngeal keratinizing squamous cell carcinoma Metastatic nasopharyngeal nonkeratinizing carcinoma Metastatic nasopharyngeal undifferentiated carcinoma Nasopharyngeal nonkeratinizing carcinoma Recurrent nasopharyngeal carcinoma Recurrent nasopharyngeal keratinizing squamous cell carcinoma Recurrent nasopharyngeal undifferentiated carcinoma Stage IV nasopharyngeal carcinoma ajcc V8 Stage IVA nasopharyngeal carcinoma ajcc V8 Stage IVB nasopharyngeal carcinoma ajcc V8

Contacts and locations

Locations

  • 21st Century Oncology-Pontiac

    Pontiac, Michigan, 48341, United States

  • Academic Hematology Oncology Specialists

    Grosse Pointe Woods, Michigan, 48236, United States

  • Advanced Breast Care Center PLLC

    Warren, Michigan, 48088, United States

  • Alaska Breast Care and Surgery LLC

    Anchorage, Alaska, 99508, United States

  • Alaska Oncology and Hematology LLC

    Anchorage, Alaska, 99508, United States

  • Alaska Women's Cancer Care

    Anchorage, Alaska, 99508, United States

  • Alegent Health Bergan Mercy Medical Center

    Omaha, Nebraska, 68124, United States

  • Alegent Health Immanuel Medical Center

    Omaha, Nebraska, 68122, United States

  • Alegent Health Lakeside Hospital

    Omaha, Nebraska, 68130, United States

  • Alegent Health Mercy Hospital

    Council Bluffs, Iowa, 51503, United States

  • Alta Bates Summit Medical Center - Summit Campus

    Oakland, California, 94609, United States

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska, 98508, United States

  • Anchorage Oncology Centre

    Anchorage, Alaska, 99508, United States

  • Anchorage Radiation Therapy Center

    Anchorage, Alaska, 99504, United States

  • Armes Family Cancer Center

    Findlay, Ohio, 45840, United States

  • Ascension Saint John Hospital

    Detroit, Michigan, 48236, United States

  • Ascension Saint Joseph Hospital

    Tawas City, Michigan, 48764, United States

  • Ascension Saint Mary's Hospital

    Saginaw, Michigan, 48601, United States

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio, 45005-1066, United States

  • Bay Area Breast Surgeons Inc

    Emeryville, California, 94608, United States

  • Bay Area Hospital

    Coos Bay, Oregon, 97420, United States

  • Bay Area Tumor Institute

    Oakland, California, 94609, United States

  • Benefis Healthcare- Sletten Cancer Institute

    Great Falls, Montana, 59405, United States

  • Bethesda North Hospital

    Cincinnati, Ohio, 45242, United States

  • Bhadresh Nayak MD PC-Sterling Heights

    Sterling Heights, Michigan, 48312, United States

  • Billings Clinic Cancer Center

    Billings, Montana, 59101, United States

  • Billings Clinic-Cody

    Cody, Wyoming, 82414, United States

  • Blanchard Valley Hospital

    Findlay, Ohio, 45840, United States

  • Bozeman Deaconess Hospital

    Bozeman, Montana, 59715, United States

  • Broadlawns Medical Center

    Des Moines, Iowa, 50314, United States

  • CHI Health Good Samaritan

    Kearney, Nebraska, 68847, United States

  • CHI Health Saint Francis

    Grand Island, Nebraska, 68803, United States

  • CHI Saint Vincent Cancer Center Hot Springs

    Hot Springs, Arkansas, 71913, United States

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526, United States

  • Cancer Center at Saint Joseph's

    Phoenix, Arizona, 85004, United States

  • Cancer Centers of Southwest Oklahoma Research

    Lawton, Oklahoma, 73505, United States

  • Capital Region Southwest Campus

    Jefferson City, Missouri, 65109, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401, United States

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois, 61938, United States

  • Carle at The Riverfront

    Danville, Illinois, 61832, United States

  • Caro Cancer Center

    Caro, Michigan, 48723, United States

  • Central Care Cancer Center - Bolivar

    Bolivar, Missouri, 65613, United States

  • Central Care Cancer Center - Garden City

    Garden City, Kansas, 67846, United States

  • Central Care Cancer Center - Great Bend

    Great Bend, Kansas, 67530, United States

  • Centralia Oncology Clinic

    Centralia, Illinois, 62801, United States

  • Chinese University of Hong Kong-Prince of Wales Hospital

    Shatin, Hong Kong, China

  • Clackamas Radiation Oncology Center

    Clackamas, Oregon, 97015, United States

  • Commonwealth Cancer Center-Corbin

    Corbin, Kentucky, 40701, United States

  • Community Hospital of Anaconda

    Anaconda, Montana, 59711, United States

  • Community Medical Hospital

    Missoula, Montana, 59804, United States

  • Contra Costa Regional Medical Center

    Martinez, California, 94553-3156, United States

  • CoxHealth South Hospital

    Springfield, Missouri, 65807, United States

  • Creighton University Medical Center

    Omaha, Nebraska, 68131, United States

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Dayton Physician LLC-Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Dayton Physicians LLC - Troy

    Troy, Ohio, 45373, United States

  • Dayton Physicians LLC-Atrium

    Franklin, Ohio, 45005, United States

  • Dayton Physicians LLC-Miami Valley South

    Centerville, Ohio, 45459, United States

  • Dayton Physicians LLC-Wayne

    Greenville, Ohio, 45331, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • Delbert Day Cancer Institute at PCRMC

    Rolla, Missouri, 65401, United States

  • Epic Care Cyberknife Center

    Walnut Creek, California, 94597, United States

  • Epic Care Partners in Cancer Care

    Emeryville, California, 94608, United States

  • Epic Care-Dublin

    Dublin, California, 94568, United States

  • Flaget Memorial Hospital

    Bardstown, Kentucky, 40004, United States

  • Franciscan Research Center-Northwest Medical Plaza

    Tacoma, Washington, 98405, United States

  • Freeman Health System

    Joplin, Missouri, 64804, United States

  • Genesee Cancer and Blood Disease Treatment Center

    Flint, Michigan, 48503, United States

  • Genesee Hematology Oncology PC

    Flint, Michigan, 48503, United States

  • Genesys Hurley Cancer Institute

    Flint, Michigan, 48503, United States

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio, 45220, United States

  • Good Samaritan Regional Health Center

    Mount Vernon, Illinois, 62864, United States

  • Great Falls Clinic

    Great Falls, Montana, 59405, United States

  • Great Lakes Cancer Management Specialists-Doctors Park

    East China Township, Michigan, 48054, United States

  • Great Lakes Cancer Management Specialists-Macomb Medical Campus

    Macomb, Michigan, 48044, United States

  • Great Lakes Cancer Management Specialists-Macomb Professional Building

    Warren, Michigan, 48093, United States

  • Great Lakes Cancer Management Specialists-Rochester Hills

    Rochester Hills, Michigan, 48309, United States

  • Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

    Grosse Pointe Woods, Michigan, 48236, United States

  • Greater Dayton Cancer Center

    Kettering, Ohio, 45409, United States

  • Greater Regional Medical Center

    Creston, Iowa, 50801, United States

  • Harrison HealthPartners Hematology and Oncology-Bremerton

    Bremerton, Washington, 98310, United States

  • Harrison HealthPartners Hematology and Oncology-Poulsbo

    Poulsbo, Washington, 98370, United States

  • Harrison Medical Center

    Bremerton, Washington, 98310, United States

  • Hawaii Cancer Care - Westridge

    ‘Aiea, Hawaii, 96701, United States

  • Hawaii Cancer Care Inc - Waterfront Plaza

    Honolulu, Hawaii, 96813, United States

  • Heartland Regional Medical Center

    Saint Joseph, Missouri, 64506, United States

  • Hematology Oncology Consultants-Clarkston

    Clarkston, Michigan, 48346, United States

  • Highline Medical Center-Main Campus

    Burien, Washington, 98166, United States

  • Holy Cross Hospital

    Fort Lauderdale, Florida, 33308, United States

  • Hope Cancer Center

    Pontiac, Michigan, 48341, United States

  • Hope Cancer Clinic

    Livonia, Michigan, 48154, United States

  • Hurley Medical Center

    Flint, Michigan, 48503, United States

  • Huron Gastroenterology PC

    Ypsilanti, Michigan, 48106, United States

  • Idaho Urologic Institute-Meridian

    Meridian, Idaho, 83642, United States

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Dixon

    Dixon, Illinois, 61021, United States

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356, United States

  • Indu and Raj Soin Medical Center

    Beavercreek, Ohio, 45431, United States

  • Iowa Lutheran Hospital

    Des Moines, Iowa, 50316, United States

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309, United States

  • Jewish Hospital

    Louisville, Kentucky, 40202, United States

  • Jewish Hospital Medical Center South

    Shepherdsville, Kentucky, 40165, United States

  • Kadlec Clinic Hematology and Oncology

    Kennewick, Washington, 99336, United States

  • Kalispell Regional Medical Center

    Kalispell, Montana, 59901, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826, United States

  • Katmai Oncology Group

    Anchorage, Alaska, 99508, United States

  • Kettering Medical Center

    Kettering, Ohio, 45429, United States

  • Kootenai Cancer Clinic

    Sandpoint, Idaho, 83864, United States

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho, 83854, United States

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho, 83814, United States

  • Kuakini Medical Center

    Honolulu, Hawaii, 96817, United States

  • LSU Health Baton Rouge-North Clinic

    Baton Rouge, Louisiana, 70805, United States

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania, 18017, United States

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania, 18103, United States

  • Lehigh Valley Hospital-Hazleton

    Hazleton, Pennsylvania, 18201, United States

  • Littleton Adventist Hospital

    Littleton, Colorado, 80122, United States

  • Longmont United Hospital

    Longmont, Colorado, 80501, United States

  • Louisiana Hematology Oncology Associates LLC

    Baton Rouge, Louisiana, 70809, United States

  • Macomb Hematology Oncology PC

    Warren, Michigan, 48093, United States

  • Mary Bird Perkins Cancer Center

    Baton Rouge, Louisiana, 70809, United States

  • Mary Greeley Medical Center

    Ames, Iowa, 50010, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • McFarland Clinic - Ames

    Ames, Iowa, 50010, United States

  • McFarland Clinic - Boone

    Boone, Iowa, 50036, United States

  • McFarland Clinic - Jefferson

    Jefferson, Iowa, 50129, United States

  • McFarland Clinic - Marshalltown

    Marshalltown, Iowa, 50158, United States

  • McFarland Clinic - Trinity Cancer Center

    Fort Dodge, Iowa, 50501, United States

  • Medical Oncology and Hematology Associates-Des Moines

    Des Moines, Iowa, 50309, United States

  • Medical Oncology and Hematology Associates-West Des Moines

    Clive, Iowa, 50325, United States

  • Memorial Hospital West

    Pembroke Pines, Florida, 33028, United States

  • Memorial Hospital of Carbondale

    Carbondale, Illinois, 62902, United States

  • Memorial Medical Center

    Springfield, Illinois, 62781, United States

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    Hollywood, Florida, 33021, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325, United States

  • Mercy Clinic-Rolla-Cancer and Hematology

    Rolla, Missouri, 65401, United States

  • Mercy Hospital Fort Smith

    Fort Smith, Arkansas, 72903, United States

  • Mercy Hospital Joplin

    Joplin, Missouri, 64804, United States

  • Mercy Hospital Oklahoma City

    Oklahoma City, Oklahoma, 73120, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Mercy Hospital South

    St Louis, Missouri, 63128, United States

  • Mercy Hospital Springfield

    Springfield, Missouri, 65804, United States

  • Mercy Hospital Washington

    Washington, Missouri, 63090, United States

  • Mercy Medical Center

    Durango, Colorado, 81301, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa, 50266, United States

  • Methodist Medical Center of Illinois

    Peoria, Illinois, 61636, United States

  • Methodist West Hospital

    West Des Moines, Iowa, 50266-7700, United States

  • Miami Valley Hospital

    Dayton, Ohio, 45409, United States

  • Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Miami Valley Hospital South

    Centerville, Ohio, 45459, United States

  • Michigan Breast Specialists-Grosse Pointe Woods

    Grosse Pointe Woods, Michigan, 48236, United States

  • Michigan Breast Specialists-Macomb Township

    Macomb, Michigan, 48044, United States

  • Michigan Breast Specialists-Warren

    Warren, Michigan, 48093, United States

  • Midlands Community Hospital

    Papillion, Nebraska, 68046, United States

  • Mission Cancer and Blood - Laurel

    Des Moines, Iowa, 50314, United States

  • Mission Hope Medical Oncology - Arroyo Grande

    Arroyo Grande, California, 93420, United States

  • Mission Hope Medical Oncology - Santa Maria

    Santa Maria, California, 93444, United States

  • Missouri Baptist Medical Center

    St Louis, Missouri, 63131, United States

  • Missouri Baptist Outpatient Center-Sunset Hills

    Sunset Hills, Missouri, 63127, United States

  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri, 63080, United States

  • National Cancer Centre Singapore

    Singapore, 168583, Singapore

  • Nebraska Methodist Hospital

    Omaha, Nebraska, 68114, United States

  • Newland Medical Associates-Clarkston

    Clarkston, Michigan, 48346, United States

  • Newland Medical Associates-Pontiac

    Pontiac, Michigan, 48341, United States

  • Northwest Medical Specialties PLLC

    Tacoma, Washington, 98405, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Oncology Hematology Associates of Saginaw Valley PC

    Saginaw, Michigan, 48604, United States

  • Oncology Hematology Care Inc-Kenwood

    Cincinnati, Ohio, 45236, United States

  • Orion Cancer Care

    Findlay, Ohio, 45840, United States

  • Our Lady of the Lake Physicians Group - Medical Oncology

    Baton Rouge, Louisiana, 70809, United States

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California, 93401, United States

  • Pacific Gynecology Specialists

    Seattle, Washington, 98104, United States

  • Pali Momi Medical Center

    ‘Aiea, Hawaii, 96701, United States

  • Parker Adventist Hospital

    Parker, Colorado, 80138, United States

  • Parkland Health Center - Farmington

    Farmington, Missouri, 63640, United States

  • PeaceHealth Saint John Medical Center

    Longview, Washington, 98632, United States

  • PeaceHealth Saint Joseph Medical Center

    Bellingham, Washington, 98225, United States

  • PeaceHealth Southwest Medical Center

    Vancouver, Washington, 98664, United States

  • PeaceHealth United General Medical Center

    Sedro-Woolley, Washington, 98284, United States

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado, 80907, United States

  • Pocono Medical Center

    East Stroudsburg, Pennsylvania, 18301, United States

  • Porter Adventist Hospital

    Denver, Colorado, 80210, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, 99508, United States

  • Providence Cancer Institute Clackamas Clinic

    Clackamas, Oregon, 97015, United States

  • Providence Newberg Medical Center

    Newberg, Oregon, 97132, United States

  • Providence Portland Medical Center

    Portland, Oregon, 97213, United States

  • Providence Regional Cancer Partnership

    Everett, Washington, 98201, United States

  • Providence Regional Cancer System-Aberdeen

    Aberdeen, Washington, 98520, United States

  • Providence Regional Cancer System-Centralia

    Centralia, Washington, 98531, United States

  • Providence Regional Cancer System-Lacey

    Lacey, Washington, 98503, United States

  • Providence Regional Cancer System-Shelton

    Shelton, Washington, 98584, United States

  • Providence Regional Cancer System-Yelm

    Yelm, Washington, 98597, United States

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    Burbank, California, 91505, United States

  • Providence Saint Mary Regional Cancer Center

    Walla Walla, Washington, 99362, United States

  • Providence Saint Vincent Medical Center

    Portland, Oregon, 97225, United States

  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii, 96813, United States

  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii, 96817, United States

  • Queen's Cancer Center - Pearlridge

    ‘Aiea, Hawaii, 96701, United States

  • Queen's Medical Center

    Honolulu, Hawaii, 96813, United States

  • Reid Health

    Richmond, Indiana, 47374, United States

  • Rocky Mountain Cancer Centers-Longmont

    Longmont, Colorado, 80501, United States

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado, 80907, United States

  • Rush - Copley Medical Center

    Aurora, Illinois, 60504, United States

  • Rush-Copley Healthcare Center

    Yorkville, Illinois, 60560, United States

  • SIH Cancer Institute

    Carterville, Illinois, 62918, United States

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, 83706, United States

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho, 83605, United States

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho, 83687, United States

  • Saint Alphonsus Medical Center-Baker City

    Baker City, Oregon, 97814, United States

  • Saint Alphonsus Medical Center-Ontario

    Ontario, Oregon, 97914, United States

  • Saint Anthony Hospital

    Lakewood, Colorado, 80228, United States

  • Saint Anthony Regional Hospital

    Carroll, Iowa, 51401, United States

  • Saint Anthony's Health

    Alton, Illinois, 62002, United States

  • Saint Charles Health System

    Bend, Oregon, 97701, United States

  • Saint Charles Health System-Redmond

    Redmond, Oregon, 97756, United States

  • Saint Clare Hospital

    Lakewood, Washington, 98499, United States

  • Saint Elizabeth Boardman Hospital

    Boardman, Ohio, 44512, United States

  • Saint Elizabeth Hospital

    Enumclaw, Washington, 98022, United States

  • Saint Elizabeth Regional Medical Center

    Lincoln, Nebraska, 68510, United States

  • Saint Elizabeth Youngstown Hospital

    Youngstown, Ohio, 44501, United States

  • Saint Francis Hospital

    Federal Way, Washington, 98003, United States

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703, United States

  • Saint John Macomb-Oakland Hospital

    Warren, Michigan, 48093, United States

  • Saint Joseph Hospital East

    Lexington, Kentucky, 40509, United States

  • Saint Joseph London

    London, Kentucky, 40741, United States

  • Saint Joseph Mercy Brighton

    Brighton, Michigan, 48114, United States

  • Saint Joseph Mercy Canton

    Canton, Michigan, 48188, United States

  • Saint Joseph Mercy Chelsea

    Chelsea, Michigan, 48118, United States

  • Saint Joseph Mercy Hospital

    Ann Arbor, Michigan, 48106, United States

  • Saint Joseph Mercy Oakland

    Pontiac, Michigan, 48341, United States

  • Saint Joseph Radiation Oncology Resource Center

    Lexington, Kentucky, 40504, United States

  • Saint Joseph Regional Cancer Center

    Bryan, Texas, 77802, United States

  • Saint Joseph Warren Hospital

    Warren, Ohio, 44484, United States

  • Saint Louis Cancer and Breast Institute-Ballwin

    Ballwin, Missouri, 63011, United States

  • Saint Louis Cancer and Breast Institute-South City

    St Louis, Missouri, 63109, United States

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712, United States

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho, 83619, United States

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho, 83642, United States

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho, 83686, United States

  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, Idaho, 83301, United States

  • Saint Mary Corwin Medical Center

    Pueblo, Colorado, 81004, United States

  • Saint Mary's Oncology/Hematology Associates of Marlette

    Marlette, Michigan, 48453, United States

  • Saint Mary's Oncology/Hematology Associates of West Branch

    West Branch, Michigan, 48661, United States

  • Saint Patrick Hospital - Community Hospital

    Missoula, Montana, 59802, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin, 54301, United States

  • Saint Vincent Hospital Cancer Center at Saint Mary's

    Green Bay, Wisconsin, 54303, United States

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri, 63670, United States

  • Saints Mary and Elizabeth Hospital

    Louisville, Kentucky, 40215, United States

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Cancer Center Worthington

    Worthington, Minnesota, 56187, United States

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, 56601, United States

  • Sanford Medical Center Fargo

    Fargo, North Dakota, 58104, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • Sanford South University Medical Center

    Fargo, North Dakota, 58103, United States

  • Sanford Thief River Falls Medical Center

    Thief River Falls, Minnesota, 56701, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Siteman Cancer Center at Christian Hospital

    St Louis, Missouri, 63136, United States

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri, 63376, United States

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141, United States

  • Siteman Cancer Center-South County

    St Louis, Missouri, 63129, United States

  • Southeast Cancer Center

    Cape Girardeau, Missouri, 63703, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • Southpointe-Sanford Medical Center Fargo

    Fargo, North Dakota, 58103, United States

  • Southwest Oncology PC

    Durango, Colorado, 81301, United States

  • Sparrow Hospital

    Lansing, Michigan, 48912, United States

  • Springfield Clinic

    Springfield, Illinois, 62702, United States

  • Springfield Regional Cancer Center

    Springfield, Ohio, 45504, United States

  • Springfield Regional Medical Center

    Springfield, Ohio, 45505, United States

  • Stanford Cancer Institute Palo Alto

    Palo Alto, California, 94304, United States

  • Straub Clinic and Hospital

    Honolulu, Hawaii, 96813, United States

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington, 98026, United States

  • Swedish Cancer Institute-Issaquah

    Issaquah, Washington, 98029, United States

  • Swedish Medical Center-Ballard Campus

    Seattle, Washington, 98107, United States

  • Swedish Medical Center-Cherry Hill

    Seattle, Washington, 98122-5711, United States

  • Swedish Medical Center-First Hill

    Seattle, Washington, 98122, United States

  • The Cancer Center of Hawaii-Liliha

    Honolulu, Hawaii, 96817, United States

  • The Cancer Center of Hawaii-Pali Momi

    ‘Aiea, Hawaii, 96701, United States

  • The Carle Foundation Hospital

    Urbana, Illinois, 61801, United States

  • TriHealth Cancer Institute-Anderson

    Cincinnati, Ohio, 45255, United States

  • TriHealth Cancer Institute-Westside

    Cincinnati, Ohio, 45247, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan, 48197, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan, 48154, United States

  • Trinity Regional Medical Center

    Fort Dodge, Iowa, 50501, United States

  • University Health Network-Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Cincinnati Cancer Center-West Chester

    West Chester, Ohio, 45069, United States

  • University of Hawaii Cancer Center

    Honolulu, Hawaii, 96813, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • UofL Health Medical Center Northeast

    Louisville, Kentucky, 40245, United States

  • Upper Valley Medical Center

    Troy, Ohio, 45373, United States

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia, 23235, United States

  • Valley Radiation Oncology

    Peru, Illinois, 61354, United States

  • Virginia Commonwealth University/Massey Cancer Center

    Richmond, Virginia, 23298, United States

  • Walter Knox Memorial Hospital

    Emmett, Idaho, 83617, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Wayne Hospital

    Greenville, Ohio, 45331, United States

  • Welch Cancer Center

    Sheridan, Wyoming, 82801, United States

  • Western Illinois Cancer Treatment Center

    Galesburg, Illinois, 61401, United States

  • Wilcox Memorial Hospital and Kauai Medical Clinic

    Lihue, Hawaii, 96766, United States

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