Promising combo for advanced cancers hits snag: trial terminated early
NCT ID NCT04916002
First seen Jan 08, 2026 · Last updated May 21, 2026 · Updated 22 times
Summary
This study tested whether combining two drugs—vidutolimod (injected into tumors) and cemiplimab (given through a vein)—could shrink or control advanced cancers like Merkel cell carcinoma, skin cancer, breast cancer, lung cancer, and throat cancer. The trial enrolled 77 adults and planned to give treatment for up to 2 years, but it was terminated early. The main goal was to see how many patients' tumors responded, and to check safety. Because lifelong medication may be needed, this is considered disease control, not a cure.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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City of Hope
Duarte, California, 91010, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dartmouth Clinical Trial Office
Lebanon, New Hampshire, 03756, United States
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East Carolina University
Greenville, North Carolina, 27858, United States
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Fiona Stanley Hospital
Murdoch, Western Australia, 6150, Australia
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GenesisCare USA
Jacksonville, Florida, 32204, United States
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Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Norton Cancer Institute
Louisville, Kentucky, 40202, United States
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OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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Oncology Consultants
Houston, Texas, 77030, United States
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Orlando Health Cancer Institute
Orlando, Florida, 32806, United States
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Peter MacCallum Cancer Centre (PMCC) and The Royal Melbourne Hospital
Melbourne, Victoria, 3050, Australia
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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St. Vincent's Hospital
Darlinghurst, New South Wales, 2010, Australia
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UC San Diego Moores Cancer Center
La Jolla, California, 92037-0845, United States
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University of Alabama
Birmingham, Alabama, 35294, United States
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University of California
Los Angeles, California, 90095, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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University of Utah Huntsman Cancer Center
Salt Lake City, Utah, 84112, United States
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University of Washington
Seattle, Washington, 98109, United States
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VA Maryland Health Care System
Baltimore, Maryland, 20814, United States
Conditions
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