MERKEL CELL CARCINOMA

This study tests a new combination treatment for Merkel cell carcinoma, a rare and aggressive skin cancer. It combines a radioactive drug (Lutathera) that kills cancer cells with an immunotherapy drug (pembrolizumab) that helps the immune system fight the cancer. The study will e…

This study tests a treatment made from your own immune cells (called TILs) that were found inside your tumor. These cells are multiplied in a lab and given back to you along with chemotherapy and a drug called IL-2. The goal is to see if this combination is safe and can shrink tu…

This early-phase study tests a new drug called AZD6750, which is designed to guide the immune system to attack cancer cells. It is for adults with advanced solid tumors like melanoma, lung cancer, or breast cancer that have not responded to other treatments. The study will check …

This study tests whether adding the drug tarlatamab to standard radiation is safe and effective for cancers that have a protein called DLL3. About 30 adults with cancers like melanoma, lung cancer, or glioblastoma will receive the combination. The goal is to find the best timing …

This study tests whether giving two immunotherapy drugs (nivolumab and relatlimab) before surgery can improve outcomes for people with stage I to III Merkel cell carcinoma, a rare skin cancer. About 20 adults with resectable tumors will receive the drugs for six weeks, then have …

This study tests a shorter, higher-dose radiation schedule (hypofractionated radiation) for people with Merkel cell carcinoma, a rare skin cancer. The goal is to see if this approach can control the cancer at the original site and nearby lymph nodes for at least two years. About …

This early-phase study tests a new drug called CRD3874-SI in people with advanced solid tumors, including sarcoma and Merkel cell carcinoma. The main goal is to find the safest dose and see if it can shrink tumors. About 81 participants will receive different doses to check side …

This study tests a new experimental drug called GI-101, given alone or with other cancer drugs (pembrolizumab or lenvatinib), in people with advanced solid tumors that have spread. The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults with canc…

This study is for people with Merkel cell carcinoma, a rare skin cancer, that can be removed with surgery. The goal is to see if giving the immunotherapy drug pembrolizumab before and after surgery can shrink the tumor and lower the chance of the cancer coming back. About 15 part…

This study tests an experimental oral drug called NEO212 in adults with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it can slow tumor growth. About 134 participants will receive NEO212 a…

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed by surgery. The treatment uses short electric pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to shrink tu…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively treat BK and JC virus infections in 100 people with cancer, HIV/AIDS, or organ transplants. These viruses can cause serious problems like kidney damage or brain…

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests whether EMLA numbing cream can reduce pain from Technetium 99 injections used in lymphoscintigraphy, a standard mapping procedure for skin cancers like melanoma. About 100 adults with skin cancer will receive either EMLA cream or a placebo before the injection. R…

This study is testing a new tool that predicts whether immunotherapy will work for people with melanoma and other skin cancers. Researchers will collect tumor tissue, blood, and stool samples from 1,000 participants and compare the tool's predictions to actual treatment outcomes.…