MERKEL CELL CARCINOMA

This study is for people with advanced Merkel cell carcinoma that has spread or cannot be removed by surgery and has stopped responding to standard immunotherapy. The researchers are testing whether giving a special type of radiation therapy (CART) together with the immunotherapy…

This study is for people with advanced solid tumors (like lung, bladder, or skin cancer) that have stopped responding to standard immunotherapy drugs called PD-1/PD-L1 inhibitors. Researchers are testing a new combination of immune-boosting drugs to see if they can shrink tumors …

This study tests whether adding a precise type of radiation (SBRT) to a two-drug immunotherapy combination (nivolumab and ipilimumab) works better than the drugs alone for people with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. About 50 adults whose cancer …

This study tests two drugs, lenvatinib and pembrolizumab, given before surgery to people with Merkel cell carcinoma, a rare skin cancer. The goal is to see if the combination can shrink or eliminate the tumor before it is removed. The trial enrolled 26 adults with stage II to IV …

This small pilot study looks at whether doing 20-30 minutes of moderate exercise right before immunotherapy can help the treatment work better for people with certain skin cancers (melanoma, squamous cell carcinoma, and Merkel cell carcinoma). The study includes 12 adults schedul…

This study tests whether a combination of three immunotherapy drugs can help people with advanced Merkel cell carcinoma that has stopped responding to standard treatment. The drugs work together to reactivate the immune system to fight the cancer. The trial involves 12 adults who…

This study tests a drug called RP1, which is injected directly into skin cancer tumors. It is for people who have had an organ or stem cell transplant and now have advanced skin cancer. The goal is to see if RP1 can shrink tumors safely without harming the transplanted organ. Abo…

This early-phase study tests whether giving the drug cemiplimab before tumor removal surgery is safe for people with Merkel cell carcinoma or cutaneous squamous cell carcinoma. About 36 adults with stage I-II or recurrent disease will receive the drug and then have surgery. Resea…

This study tests whether the immunotherapy drug avelumab can help prevent Merkel cell carcinoma from coming back after initial treatment. About 122 people with stage I to III Merkel cell carcinoma are randomly assigned to receive either avelumab or a placebo. The main goal is to …

This study tests whether giving a short course of chemo-immunotherapy before surgery can improve outcomes for people with Merkel cell carcinoma, a rare skin cancer. About 36 adults with operable tumors will receive one cycle of retifanlimab plus chemotherapy, then undergo surgery…

This early-phase study is testing a new form of the chemotherapy drug topotecan, wrapped in a liposome (a tiny fat bubble), to see if it is safe and what dose works best. About 96 adults with advanced solid tumors (including ovarian, cervical, sarcoma, and certain lung and skin c…

This early-stage trial tests a new treatment called BOXR1030, which uses specially engineered immune cells to attack cancer cells that have a protein called GPC3. The study includes adults with advanced liver, lung, skin, or soft-tissue cancers that have not responded to other tr…

This study tests a two-step treatment for people with rare skin cancers or certain lymphomas that haven't responded to standard care. First, patients receive a virus-based therapy (talimogene laherparepvec) that infects and kills tumor cells. Then, they also get an immunotherapy …

This early-phase study tests whether 30 minutes of moderate exercise (like cycling or walking) right before each immunotherapy treatment can help the body fight skin cancers such as melanoma. The study involves 22 adults who are about to start standard immunotherapy. Researchers …

This early-phase study tests whether a mix of drugs and targeted radiation can help the immune system recognize and attack hard-to-treat solid tumors. About 14 adults with advanced melanoma, breast cancer, or other solid cancers that cannot be surgically removed will receive inje…

This study is testing a new type of PET/CT scan that uses a special tracer (68Ga-DOTATOC) to find neuroendocrine tumors and other related cancers. The goal is to see if this scan is safer and more sensitive than current imaging methods. About 800 people with known or suspected tu…