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New combo therapy before surgery shows promise for rare skin cancer

NCT ID NCT05594290

First seen Jan 20, 2026 · Last updated May 25, 2026 · Updated 15 times

Summary

This study tests whether giving a short course of chemo-immunotherapy before surgery can improve outcomes for people with Merkel cell carcinoma, a rare skin cancer. About 36 adults with operable tumors will receive one cycle of retifanlimab plus chemotherapy, then undergo surgery. The main goal is to see how many patients have no cancer left in the removed tissue.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Fondazione IRCCS Istituto Nazionale dei Tumori di Milano

    Milan, 20133, Italy

Conditions

Explore the condition pages connected to this study.