CUTANEOUS SQUAMOUS CELL CARCINOMA

This study tests a small adhesive patch with tiny needles that deliver a low dose of the chemotherapy drug doxorubicin directly into skin cancer tumors. The goal is to see if the patch is safe and can shrink or clear the cancer. The trial includes up to 48 adults with early-stage…

This early-phase study tests a new drug called tolododekin alfa (ANK-101) in people with advanced solid tumors that have not responded to standard treatments. The drug is injected directly into tumors to see if it is safe and tolerable. About 97 adults with various cancers, inclu…

This study tests a treatment made from your own immune cells (called TILs) that were found inside your tumor. These cells are multiplied in a lab and given back to you along with chemotherapy and a drug called IL-2. The goal is to see if this combination is safe and can shrink tu…

This study tests a drug called ivonescimab in people with advanced cutaneous squamous cell carcinoma (cSCC) that cannot be removed by surgery or has spread. The goal is to see if the drug can help control the cancer and to check for side effects. About 24 participants will take p…

This study tests whether giving two immunotherapy drugs (nivolumab and relatlimab) before surgery can shrink advanced skin cancer (cutaneous squamous cell carcinoma) and lower the chance of it coming back. About 20 adults with stage II to IV cancer that can be removed will receiv…

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This study tests whether a special 3D ultrasound can accurately measure how deep a skin cancer (squamous cell carcinoma) goes after it's removed. About 30 adults will have their tumor scanned with 3D ultrasound after surgery, and the results will be compared to standard lab tests…

This study tests whether adding a special heat treatment (water-filtered infrared-A, or wIRA) to standard palliative radiation can help shrink tumors and ease symptoms in people with advanced head, neck, or skin cancers that cannot be cured. About 60 adults will receive the combi…

This study is testing a blood test (liquid biopsy) to see if it can find tiny bits of cancer DNA left behind after surgery for a type of skin cancer called cutaneous squamous cell carcinoma. The test may also help doctors monitor how well immunotherapy treatment is working. About…

This study is testing a new tool that predicts whether immunotherapy will work for people with melanoma and other skin cancers. Researchers will collect tumor tissue, blood, and stool samples from 1,000 participants and compare the tool's predictions to actual treatment outcomes.…

This study looks at 1,500 people with a common skin cancer called cutaneous squamous cell carcinoma. Researchers want to see how well current staging systems predict if the cancer will come back or spread. The goal is to improve how doctors assess risk and manage this cancer.