Otorhinolaryngologic disease

This phase 3 trial tests whether adding sintilimab, an immunotherapy drug, to chemotherapy before surgery helps people with early-stage oral squamous cell carcinoma. Participants are adults aged 18 to 75 with cT2N0M0 oral cancer that can be removed by surgery. Half receive sintil…

Researchers test a surgical technique that uses a boomerang-shaped piece of the patient's own cartilage and tissue to repair hard-to-close eardrum perforations. The study includes 50 adults with anterior or subtotal perforations that have been dry for at least three months. Surge…

This phase 2 trial is testing whether giving two drugs before surgery can help people with advanced oral cavity cancer. The drugs, becotatug vedotin and pucotenlimab, are designed to attack cancer cells and boost the immune system. Participants receive three cycles of the combina…

This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

Researchers are testing whether adding CT-guided thermal ablation of liver or lung metastases to standard systemic therapy improves tumor response in people with nasopharyngeal carcinoma. The trial enrolls 138 adults whose primary tumor was cured but who later developed up to fiv…

This phase II trial tests whether the experimental drug BL-B01D1, given with or without a PD-1 antibody, can improve tumor shrinkage in people with high-risk locally advanced nasopharyngeal carcinoma, a type of throat cancer. Participants also receive standard chemotherapy drugs …

This phase III trial is testing whether adding an experimental drug called BL-B01D1 to standard maintenance therapy with a PD-1 antibody can help people with recurrent or metastatic nasopharyngeal carcinoma live longer without their cancer progressing. Participants first receive …

Researchers are testing an experimental drug called BL-M08D1 in adults with nasopharyngeal carcinoma that has come back or spread, as well as other solid tumors. Participants receive the drug by intravenous infusion every three weeks. The trial aims to find a safe dose for furthe…

This study tests whether a blood test that detects HPV DNA can help doctors choose the right treatment for people with HPV-positive oropharyngeal cancer. About 116 participants with stage I to III cancer will receive either the immunotherapy drug pembrolizumab (Keytruda) or stand…

Researchers are testing whether adding rimegepant to standard chemoimmunotherapy before surgery helps shrink oral or oropharyngeal squamous cell carcinoma more effectively. The trial enrolls adults with primary or recurrent disease who are scheduled for surgery. Participants rece…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This trial tests whether adding a nasal spray made from pistacia lentiscus oil can help people with chronic rhinosinusitis control their symptoms while using a lower dose of a standard corticosteroid spray. Adults with the condition will be randomly assigned to either the oil spr…

This phase 2 trial tests a combination of two drugs, XL-092 and pembrolizumab (Keytruda), given before surgery to people with a type of oral cancer that is HPV-negative and can be removed. The goal is to see if the drugs can shrink or eliminate the tumor before the operation. Abo…

This phase II trial tests a new treatment approach for people with locally advanced nasopharyngeal carcinoma, a type of head and neck cancer. The regimen avoids platinum-based chemotherapy, using a combination of gemcitabine, camrelizumab, endostar, and low-dose radiotherapy befo…

This trial is testing whether CRB-701, a targeted chemotherapy that delivers a potent drug directly to cancer cells, can shrink tumors and extend life in people with recurrent or metastatic oropharyngeal (throat or tonsil) cancer. Participants will have already tried platinum-bas…

This trial tests whether a newer head-and-body movement, called Semont-plus, works better than the standard Epley maneuver for treating a common type of vertigo caused by loose crystals in the inner ear. Adults with posterior canal BPPV will be randomly assigned to one of the two…

This trial tests whether people with early-stage nasopharyngeal cancer who respond well to induction chemotherapy can safely receive a lower dose of radiation than the standard. Participants whose tumors shrink significantly and whose EBV-DNA drops to zero after chemo are randoml…

This trial tests whether adding a nasal spray made from Pistacia lentiscus oil (Bactorinol®) can help people with chronic rhinosinusitis maintain their quality of life when their steroid nasal spray dose is reduced. Participants first use a full dose of mometasone for 12 weeks, t…

This phase II trial is testing whether adding a special type of radiation therapy to the immunotherapy drug pembrolizumab before surgery can help shrink oral cavity tumors. The study compares two radiation techniques: proton spatially fractionated radiotherapy (SFRT), which deliv…

This phase 3 trial tests whether the experimental drug felcorekibart, added to standard care, can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a…

This phase 3 trial tests whether an experimental drug called felcorekibart can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a placebo on top of …

This phase II trial is testing whether combining a TROP-2 antibody-drug conjugate (sacituzumab govitecan or sacituzumab tirumotecan) with the immunotherapy drug toripalimab can shrink tumors in people with resectable, locally advanced oral squamous cell carcinoma. Participants re…

This trial tests a device called EarFlo, which delivers a small puff of air through the nose during swallowing to help open the Eustachian tube and equalize pressure in the middle ear. It is designed for adults with Eustachian tube dysfunction or fluid buildup in the ear (otitis …

This phase 2 trial is testing whether combining the immunotherapy drug pembrolizumab with a short course of high-dose radiation, with or without additional radiation to nearby lymph nodes, can shrink or eliminate head and neck tumors before surgery. Adults with resectable squamou…

This trial asks whether it is safe to skip the routine removal of impacted teeth before radiation therapy for nasopharyngeal carcinoma. Half of the participants will have the extraction as usual, while the other half will not. The study will compare the risk of jaw bone damage (o…

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This early-stage trial tests a new cell therapy called Rincell-1 for adults with certain types of hearing loss who are getting a cochlear implant. The study will compare the safety and early effectiveness of receiving the cell therapy plus the implant versus the implant alone. Ab…

This trial tests whether adding the immunotherapy drugs cemiplimab (with or without fianlimab) to standard chemotherapy before chemoradiation can improve outcomes for people with advanced nasopharyngeal cancer. About 60 adults with non-metastatic, EBV-positive nasopharyngeal carc…

This trial tests whether giving two immunotherapy drugs—pembrolizumab and cetuximab—before surgery can shrink advanced oral cancers linked to betel-nut chewing. The study enrolls 20 people in the Northern Mariana Islands who have not yet received treatment. Researchers will measu…

This trial is testing whether a special type of radiation called radscopal radiotherapy—which combines low-dose radiation to the main tumor and precise high-dose radiation to distant metastases—can enhance the effects of two immunotherapy drugs (sintilimab and ipilimumab) in peop…

This phase 2 trial is testing whether giving the immunotherapy drug penpulimab together with chemotherapy before surgery can help people with locally advanced hypopharyngeal carcinoma, a type of head and neck cancer. The study will include about 15 adults aged 18 to 80 with resec…

This trial tests whether two self-assessment methods in a smartphone app can generate hearing aid settings that match those from a standard hearing test. Adults with perceived mild-to-moderate hearing loss will use the app to self-test their hearing and also undergo conventional …

This trial tests whether common antibiotics—amoxicillin or amoxicillin-clavulanate—actually reduce symptoms in children aged 2 to 12 with acute sinusitis. About 1,100 children are randomly assigned to one of the two antibiotics or a placebo, and parents track daily symptoms. The …

This trial investigates whether antibiotics like amoxicillin or amoxicillin-clavulanate ease symptoms of ear infections (acute otitis media) in children aged 6 months to 3 years better than a placebo. Over 1,100 children are randomly assigned to one of three groups, and families …

This study tests whether a special scan (SPECT-CT) can show which side of the neck needs radiation in people with oropharyngeal cancer. Currently, both sides are treated to prevent hidden cancer spread, but this causes more side effects. The trial will enroll 128 patients to see …

This early-phase trial tests an experimental drug, KGX105, in people with advanced solid tumors that have not responded to standard treatments. KGX105 is designed to activate immune T-cells specifically within the tumor, potentially reducing side effects. The study will assess sa…

This phase 2 trial tests whether adding ivonescimab—a drug that blocks both PD-1 and VEGF—to standard chemoradiotherapy improves outcomes for people with high-risk nasopharyngeal carcinoma. The study enrolls adults aged 18–65 with previously untreated stage T3N2M0 or stage III di…

This trial tests a follow-up strategy for people with nasopharyngeal cancer that has spread to neck lymph nodes (N3) after radiation therapy. Participants are assigned to standard follow-up or an enhanced approach that uses advanced imaging and a blood test (EBV DNA) to decide if…

This early-phase trial tests whether a new drug (ATRN-119) combined with a single, precise dose of radiation to the neck can safely and effectively treat early-stage HPV-positive throat cancer before surgery. About 35 participants will take the drug daily for 10 days and receive …

This Phase III trial will compare proton beam radiotherapy with standard photon radiotherapy in 504 patients with non-metastatic nasopharyngeal carcinoma. The goal is to see if proton therapy reduces toxic side effects and improves survival. Participants will be randomly assigned…

This phase II trial tests a combination of two drugs—SYS6026 and Enlonstobart—in people with advanced solid tumors that have spread and are linked to HPV types 16 or 18. The study aims to see if the combination is safe and shows signs of shrinking tumors. Participants must be at …

This large Phase 3 trial is testing a new drug called APG-157, given as a pastille that dissolves in the mouth, for people with advanced head and neck cancer. The study will see if adding APG-157 before and after standard treatments (surgery or chemoradiation) helps keep the canc…

This early study tests a new surgical device called the Microtable® Stereotactic System for cochlear implants. The device uses a custom-made frame to guide a drill precisely to the inner ear, potentially making surgery faster, less painful, and better at preserving taste. The stu…

This study tests a new nasal spray for adults with chronic sinusitis. The spray turns into a gel inside the nose and releases three active ingredients: stem cell exosomes to help repair the nasal lining, an antihistamine to reduce inflammation, and an antiviral agent. The goal is…

This early-stage trial tests a nasal spray for adults with chronic sinusitis (without polyps). The spray contains stem cell exosomes to heal the nose lining, an antibiotic to kill bacteria, and an enzyme to break up thick mucus. 108 participants will use the spray twice daily for…

This phase 2 trial tests whether the drug becotatug vedotin can prevent cancer from returning in 140 patients with high-risk nasopharyngeal carcinoma who have completed standard chemo-radiation. Participants are randomly assigned to receive the drug or standard care. The main goa…

This study tests a new treatment plan for people with HPV-positive oropharyngeal cancer (a type of throat cancer linked to HPV). The plan combines an immune-boosting drug (nogapendekin alfa inbakicept), a vaccine targeting HPV, chemotherapy, and a lower dose of radiation. The goa…

This study tests whether an Ayurvedic treatment that targets digestion and gut health can reduce allergy symptoms and immune markers in people with allergic rhinitis (hay fever). 104 adults aged 18-40 with confirmed allergies will receive either the Ayurvedic treatment plus stand…

This study looks at whether taking the drug stapokibart for 4 weeks before sinus surgery helps adults with chronic nasal polyps more than surgery alone. About 48 participants will receive either the drug or a placebo before their operation and be followed for nearly a year. The g…

This study tests whether giving a combination of anlotinib (a targeted therapy) and epirubicin (chemotherapy) before surgery can improve outcomes for people with advanced sinonasal adenoid cystic carcinoma, a rare and aggressive cancer of the nasal cavity and sinuses. About 76 pa…

This study looks at 50 infants born with a blocked tear duct (a common condition causing watery eyes). It compares two treatments: early probing (a quick procedure to open the duct) and tear duct massage. The goal is to find which approach works best and when to do it, to help ba…

This study looks at whether patients with a rare nasal cancer (sinonasal adenoid cystic carcinoma) can safely avoid radiation after surgery if the tumor was completely removed. About 200 patients will choose either surgery alone or surgery plus radiation, and researchers will tra…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This phase 2 trial is testing a drug called ivonescimab in 42 people with a type of head and neck cancer (nasopharyngeal carcinoma) that has stopped responding to standard immunotherapy and chemotherapy. The drug is given every 3 weeks by IV. Researchers will measure how many pat…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests a new treatment for people whose nasopharyngeal cancer has come back and cannot be surgically removed. Participants will receive two cycles of a targeted drug (becotatug vedotin) plus an immunotherapy, followed by radiation and continued immunotherapy. The goal i…

This phase 3 trial tests whether adding an immunotherapy drug (PD-1 antibody) and a targeted therapy (anlotinib) to standard chemotherapy and radiation can help prevent cancer from returning in people with high-risk, advanced nasopharyngeal carcinoma. About 442 adults aged 18-65 …

This study tests whether giving two drugs together before surgery can shrink advanced mouth or throat cancers. The drugs are becotatug vedotin and pucotenlimab. About 26 people with stage III or IVa cancer will take part. The goal is to see if the cancer nearly or completely disa…

This phase 2 trial tests a combination of two drugs (Benmelstobart and Anlotinib) plus targeted radiation (SBRT) in 29 adults with liver cancer that has spread to a few other spots and no longer responds to first-line treatment. The goal is to see if this triple therapy can slow …

This Phase 3 trial tests whether adding a targeted drug (Becotatug Vedotin) to standard immunotherapy and chemo-radiation can improve outcomes for people with high-risk nasopharyngeal cancer. About 514 participants will be randomly assigned to receive either the new combo or stan…

This study tests whether giving the immunotherapy drug nivolumab before surgery can shrink tumors in people with advanced oral cancer. About 60 adults with resectable oral squamous cell carcinoma will receive nivolumab, then have surgery. Researchers will also look for biomarkers…

This trial tests whether adding natural killer (NK) cells from healthy donors to standard chemoradiotherapy can reduce the risk of cancer returning in people with advanced nasopharyngeal cancer. The study has two phases: first, finding the safest dose of NK cells, then testing th…

This phase 2 trial tests whether secukinumab, a drug that blocks IL-17A, can help people with active severe Takayasu arteritis achieve remission and stop taking steroids. About 52 participants will receive either secukinumab injections or standard care (like TNF inhibitors). The …

This study tests whether a mixed reality system, similar to video game technology, can help surgeons remove oral cancer and rebuild the area more accurately. Thirty people with oral cancer will be split into three groups: one using mixed reality, one using a virtual surgical guid…

This study tests a combination of three drugs (chidamide, toripalimab, and anlotinib) in 52 adults with recurrent or metastatic nasopharyngeal carcinoma that has failed at least one prior treatment. The goal is to find the safest dose and see how many patients' tumors shrink. Par…

This study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial …

This study tests a daily dissolving film placed under the tongue to treat dust mite allergic rhinitis (hay fever). About 250 adults in China will use either the active film or a placebo for one year. The goal is to see if the film reduces sneezing, stuffiness, and the need for re…

This study compares two types of cartilage grafts used to repair eardrum holes in adults. One graft is thin (0.5 mm) and the other is thick (1.8 mm). The goal is to see which one leads to better healing and hearing after six months. Thirty adults with long-standing eardrum perfor…

This study looks at people with advanced mouth or throat cancer who had chemotherapy and immunotherapy before surgery. After surgery, they will either get radiation, immunotherapy maintenance, or just be watched. The goal is to see which approach helps them live longer without th…

This study tests two new drugs, vunakizumab and ivarmacitinib, for people with active Takayasu arteritis (TAK), a rare disease that causes inflammation in large blood vessels. The trial will enroll 180 adults aged 18-70 whose disease is still active despite standard treatments. R…

This early-phase trial is testing whether inhaling tiny particles from stem cells (called small extracellular vesicles) can safely help people with both allergic rhinitis and asthma. About 18 adults will receive either the active treatment or a placebo via nebulizer daily for two…

This study tests a new approach for people with a certain type of throat cancer that is not low-risk. Participants first receive a combination of chemotherapy, immunotherapy, and a special type of radiation called lattice radiotherapy. Then, based on how much the tumor shrinks, t…

This Phase 3 trial tests whether giving a short course of targeted radiation (SBRT) followed by chemotherapy and immunotherapy before surgery can improve outcomes for people with advanced oral or HPV-negative throat cancer. About 184 participants will be randomly assigned to rece…

This Phase 2 trial tests a combination of two drugs—Becotatug vedotin (a targeted therapy) and Pucotenlimab (an immunotherapy)—as a first treatment for people whose nasopharyngeal cancer has come back or spread. The study will enroll 30 adults and measure how long the cancer stay…

This study will test whether using two OSIA bone conduction implants (one on each side) helps children with severe ear malformations hear better in noisy places compared to using just one implant. Twelve children aged 7 to 17 who already use a bone conduction device will receive …

This phase 2 trial tests whether giving a combination of the immunotherapy drug camrelizumab and two chemotherapy drugs (paclitaxel and carboplatin) before surgery can improve outcomes for people with advanced oral cavity or larynx cancer. Fifty participants will receive three cy…

This Phase II trial tests whether giving the immunotherapy drug toripalimab on different days during chemotherapy can improve outcomes for people with advanced nasopharyngeal cancer. About 198 participants will receive standard chemotherapy plus toripalimab on Day 1, Day 5, or Da…

This phase 2 trial tests whether combining two drugs—scipibaimab and tislelizumab—can shrink tumors in people with recurrent or metastatic nasopharyngeal carcinoma that has worsened after first-line treatment. About 37 adults whose cancer has not responded to platinum chemotherap…

This phase 3 trial tests a gel containing povidone-iodine and budesonide that is placed inside the sinuses right after endoscopic sinus surgery. The goal is to see if it reduces inflammation and scarring better than a placebo gel. The study will involve 180 adults with chronic rh…

This Phase 3 trial will test whether adding anlotinib (a drug that cuts off tumor blood supply) to standard immunotherapy and chemotherapy with radiation can improve outcomes for 412 people with high-risk nasopharyngeal cancer. Participants will receive either the new combo or st…

This phase 3 trial will test whether a shorter course of the immunotherapy drug tislelizumab, combined with chemotherapy and radiation, works as well as a longer course for people with advanced nasopharyngeal cancer. About 418 participants will be randomly assigned to receive eit…

This early-phase study tests a new type of radiation (lattice radiotherapy) given with chemotherapy and immunotherapy before surgery for oral cavity cancer. About 30 adults with advanced but removable tumors will receive different radiation doses to find the safest level. The goa…

This study tests whether a one-time booster dose of the Gardasil-9 vaccine can lengthen the time between surgeries for adults with recurrent respiratory papillomatosis (RRP), a condition where non-cancerous growths keep coming back in the airway. Researchers will enroll 50 adults…

This early-phase trial tests an mRNA immunotherapy for people with tumors linked to the Epstein-Barr virus, such as nasopharyngeal cancer, gastric cancer, and lymphoma. The treatment aims to help the immune system recognize and attack cancer cells. Researchers will check safety a…

This phase II trial tests whether surgically cutting the lingual nerve (which controls tongue sensation) can make chemoimmunotherapy work better for people with advanced tongue cancer. 69 adults with stage T3/T4 tongue cancer will receive the nerve cut along with two cycles of ti…

This study tests a two-step treatment for people whose nasopharyngeal cancer has come back after initial treatment. First, patients receive a targeted drug (MRG003) plus an immunotherapy (PD-1) for six weeks. Then, they take a chemotherapy pill (capecitabine) with the immunothera…

This study tests whether adding pirfenidone, a drug used for lung and liver scarring, to standard treatment can improve blood vessel damage in people with Takayasu arteritis. About 92 adults aged 18-60 will receive either pirfenidone or a placebo for 6 months. The goal is to see …

This study tests a surgical procedure called endoscopic stapedotomy for people with otosclerosis, a condition that causes progressive hearing loss. Surgeons will use a tiny camera to place a small artificial device in the middle ear to improve sound transmission. The study will f…

This study tests whether it is safe to skip radiation to a specific neck area (Level Va) in patients with a type of throat cancer called nasopharyngeal carcinoma. About 474 newly diagnosed patients without cancer spread will be randomly assigned to standard radiation or a reduced…

This study tests whether giving two drugs (pembrolizumab and MRG-003) before standard chemoradiation can shrink tumors in people with advanced nasopharyngeal cancer linked to Epstein-Barr virus. About 35 adults with stage III-IVa disease will receive 3 cycles of the drug combo, t…

This study tests whether the drug hetrombopag can prevent severe low platelet counts caused by chemotherapy in people with nasopharyngeal carcinoma. About 35 patients who already had low platelets during a previous chemo cycle will take hetrombopag tablets daily during their next…

This study tests whether adding chemotherapy to immunotherapy works better than immunotherapy alone for people with advanced nasopharyngeal cancer whose cancer did not fully respond to initial treatment. About 516 adults aged 18-65 with stage II-III disease will receive either th…

This study tests whether virtual reality (VR) therapy works better than standard balance exercises for people with long-term dizziness. Researchers will enroll 40 adults aged 18-70 who have had dizziness for over 3 months due to inner ear problems. Participants will receive eithe…

This study tests a cream called terbinafine hydrochloride for treating fungal ear infections (otomycosis). About 50 adults with symptoms like itching, pain, and discharge will have the cream applied in the ear every two days for two weeks. The goal is to see if the cream clears b…

This study compares two surgical techniques for infants born with choanal atresia, a condition where the nasal passages are blocked. Thirty infants up to 6 years old will receive either a puncture with mitomycin C or a flap technique. The goal is to see which method keeps the air…

This phase II trial tests whether giving pembrolizumab (an immunotherapy) plus chemotherapy before surgery, followed by maintenance pembrolizumab, can improve outcomes for people with locally recurrent nasopharyngeal carcinoma. About 53 participants will receive up to 6 cycles of…

This study tests whether a person's own platelet-rich plasma (PRP) can improve smell when placed in the nose on a gel sponge versus being injected. Sixty adults with smell loss lasting over three months will receive one treatment and then do smell training for three months. Resea…

This study tests whether special MRI scans can predict how well HPV-positive throat cancer responds to standard chemotherapy and radiation. Researchers will scan 30 adults before treatment and track their outcomes. The goal is to see if MRI patterns can identify low-risk patients…

This trial is testing two new imaging tracers, called CM500, to see if they can help detect solid tumors anywhere in the body. The tracers are given by injection and then used with PET scans to create detailed images. The study includes healthy volunteers and people with various …

This pilot study tests a new imaging system that uses OCT and vibrometry to let doctors see the middle ear bones and measure how they move in response to sound. The study enrolls 500 adults with conductive or sensorineural hearing loss. The goal is to compare these detailed motio…

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study aims to see if a simple blood test can find HPV-related oropharyngeal cancer early in men aged 50 and older who have no symptoms. Researchers will check blood for two markers of HPV and then follow up with those who test positive to find and treat any tumors. If succes…

This study will test artificial intelligence algorithms that analyze video from routine endoscopies of the head and neck. The AI will try to detect, classify (benign vs. malignant), and outline lesions, comparing its performance to doctors and lab results. About 283 adults with s…

This study will collect thousands of photos of mouth lesions from patients seen over 50 years at a French hospital. Experts will review each photo to confirm the diagnosis. Researchers will then use these images and patient data to train an AI system to automatically identify can…

This study tests a new laser otoscope to see if it helps doctors find fluid behind the eardrum in children. About 150 kids already scheduled for ear tube surgery will get both a laser and a standard white-light ear exam. The results will be compared to what the surgeon finds duri…

This study aims to see if a simple vibration test at the ankle can identify patients with superior canal dehiscence syndrome (SCDS), a condition where a thin bone in the ear causes hearing of internal body sounds or pulsatile tinnitus. Researchers will test 30 adults with these s…

This study tests whether a gamified training program for doctors, plus an AI tool that analyzes ear drum images, can improve the accuracy of diagnosing ear infections (otitis media). About 200 patients with ear symptoms will be seen by doctors who either received the training or …

This study tests whether a smartphone algorithm (Glimpse) can accurately diagnose ear infections in children aged 6 months to 6 years. Parents and doctors will take videos of the child's ear, and the AI's diagnosis will be compared to that of an ear specialist. The goal is to see…

This study aims to find the best concentration of Blomia tropicalis (a type of dust mite) extract for allergy skin testing. About 30 adults with known dust mite allergies will receive small pricks with different extract strengths to see which causes a reaction similar to a standa…

This trial tests whether a daily supplement called Immune X can help prevent common colds in healthy adults who often get upper respiratory infections. Over 16 weeks during winter, participants take either Immune X or a placebo and track any cold symptoms. The study compares how …

This pilot study tests two light therapy devices—one placed inside the mouth and one outside—to prevent and treat painful mouth sores caused by radiation therapy. Sixty adults with oral cavity or oropharynx cancer will receive light sessions twice a week for prevention, then thre…

This study tests whether removing a thin layer of tissue (pseudomembrane) from the back of the nose using a scope can prevent radiation-induced tissue death in patients with recurrent nasopharyngeal cancer who have had repeat radiation. About 40 adults in China will undergo the p…

This study tests whether a modified herbal mouthwash can prevent painful mouth sores caused by radiation therapy in people with head and neck cancer. About 156 participants will use either the herbal mouthwash or a placebo during their radiation treatment. The goal is to see if t…

This study tests whether a steroid nasal spray can prevent fluid buildup in the middle ear, a common side effect of radiation therapy for nasopharyngeal cancer. About 168 adults who are about to start radiation will use either the spray or a placebo for 12 months. The goal is to …

This study compares two ways to give steroid medicine to people with chronic sinusitis who have lost their sense of smell due to blocked nasal passages. One group will get standard steroid spray, while the other gets steroid drops placed directly where smell happens. The goal is …

Researchers want to see whether facial photographs can show how well a fluticasone propionate nasal spray eases facial allergy symptoms. The study enrolls 16 adults with moderate to severe seasonal allergic rhinitis. Participants use the nasal spray and have their faces photograp…

This trial asks whether adding a specific type of acupuncture—targeting a nerve bundle behind the nose—to a standard nasal steroid spray can ease allergic rhinitis symptoms like sneezing, congestion, and itching better than the spray alone. Adults with moderate-to-severe perennia…

This trial tests whether giving IV fluids on a fixed schedule during chemoradiation for head and neck cancer can reduce severe side effects like mouth sores, swallowing problems, and kidney injury. Half of the participants will receive IV fluids twice a week starting in week 3 of…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study is for people with HPV-related oropharyngeal (throat) cancer, which often responds well to treatment. The goal is to see if lowering the radiation dose to certain areas can reduce side effects like dry mouth without hurting the chance of curing the cancer. About 132 pa…

This trial tests whether chewing sugar-free gum for 20 minutes, alongside standard intravenous medication, can reduce dizziness and nausea in adults with a common inner-ear condition called posterior canal BPPV. Participants are randomly assigned to either chew gum or receive sta…

This study tests whether applying bee venom to the face using ultrasound can ease chronic sinusitis symptoms. Thirty adults with sinusitis will either get bee venom phonophoresis or standard care (decongestants and saline rinses). Researchers will measure changes in symptom sever…

This study tests whether a mobile-based rehabilitation program, built on the PERMA-H model of well-being, can improve hope, self-confidence, and social support in people recovering from a tracheostomy due to oral cancer. Participants use a WeChat mini-program with a chatbot and t…

This study compares two ways to lift the soft palate during throat surgery to see which causes fewer injuries. About 138 people aged 2 to 70 who need this type of surgery will be randomly assigned to either the standard double-strap method or a new full-wrap method. The goal is t…

This study looks at whether a special pillow that combines cold therapy and arm elevation can help children aged 7 to 12 feel less anxious and more comfortable after surgery for a broken arm. About 80 kids will be randomly assigned to use either the special pillow or standard car…

This trial compares early versus delayed acupuncture to reduce dry mouth caused by chemoradiation in head and neck cancer patients. Participants receive acupuncture either during chemoradiation or after, and their dry mouth symptoms are tracked for a year. The goal is to find the…

This study tests a new herbal blend designed to shorten the duration and reduce the severity of common cold symptoms. Researchers will enroll 300 healthy adults in Australia who get frequent colds. Participants will take the herbal product or a placebo whenever they feel a cold c…

This study tests whether osteopathic manipulative treatment (OMT) — a gentle, hands-on therapy — can reduce the need for ear tube surgery in children with chronic or recurrent ear infections. Two hundred children aged 6 months to 7 years will receive either OMT or a placebo manua…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This phase 2 trial tests the safety of stapokibart injection in 15 teenagers aged 12-17 with seasonal allergic rhinitis (hay fever). Participants receive the drug alongside their usual allergy treatments. The study focuses on side effects and how the body processes the drug, not …

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study compares two tonsil surgery methods in adults: full removal (extracapsular) and partial removal (intracapsular). The goal is to see if partial surgery allows a shorter sick leave and less need for opioid painkillers, while still being as effective at relieving tonsilli…

This study tests a new nasal spray called PL-14 Allergy Blocker in about 120 adults with seasonal allergies. Unlike regular allergy sprays, PL-14 is drug-free and works by forming a gel-like barrier in the nose to block allergens. The study compares it to a simple saline spray ov…

This study tests whether Ai Chi, a slow, controlled water exercise program, can help people with long-term dizziness from inner ear problems. 38 adults will either do standard home exercises or add Ai Chi sessions in a pool over 4 weeks. Researchers will measure changes in balanc…

This study is testing a special gel made from hyaluronan (a natural substance) to see if it can quickly ease discomfort in the throat and nose for people with chronic rhinitis and pharyngitis. Thirty adults with these conditions will use the gel twice daily for 10 days. The main …

This study tests whether special eye and balance exercises can reduce dizziness, motion sickness, and improve quality of life in people with inner-ear balance problems. Thirty-two adults with motion sickness or vertigo will do either standard habituation exercises or a new optoki…

This phase 2 trial tests whether taking taurine (a common amino acid) can prevent or reduce severe mouth sores caused by radiation therapy in people with nasopharyngeal cancer. 130 patients will take taurine pills or receive standard care starting 3 days before radiation until 1 …

This study tests whether a single one-hour educational session with an audiologist can help people with hyperacusis (extreme sensitivity to sound) feel more comfortable around everyday noises. Five participants will track their sound exposure and sensitivity for one month using a…

This study looks at whether removing the adenoids (with or without tonsils) can improve allergy symptoms in children aged 3 to 12 who also have enlarged adenoids and tonsils. Researchers will compare surgery to standard medication by tracking symptom scores and allergy markers in…

This study compares two common treatment combinations for allergic rhinitis (hay fever) in adults: a nasal steroid spray plus an oral antihistamine versus a nasal steroid spray plus an oral antileukotriene. The goal is to see which combo better relieves symptoms like sneezing, st…

This study tests whether injecting a person's own platelet-rich plasma (PRP) into the nose can help restore smell in adults who have had smell loss for more than 6 months due to aging or head injury. Thirty participants will receive three PRP injections over four weeks and be fol…

This study will test the safety of a new biologic drug called stapokibart, given as a shot, in 400 adults with seasonal allergic rhinitis (SAR). Participants are already prescribed the drug by their doctor. The main goal is to track any side effects. This is an open-label study, …

This study tests an injection called JYB1904 for people with year-round allergies (perennial allergic rhinitis). The goal is to see if it can reduce symptoms like runny nose, congestion, and sneezing better than a placebo. About 135 adults who already use nasal sprays will receiv…

This study tests whether rimegepant, a drug used for migraines, can quickly reduce dizziness from conditions like vestibular migraine. About 370 adults with moderate to severe dizziness will receive either rimegepant plus betahistine or betahistine alone. The main goal is to see …

This study tests a new medicine called AK139 for people with moderate to severe seasonal allergic rhinitis (hay fever). About 111 adults aged 18-65 with at least a 2-year history of seasonal allergies will receive either AK139 or a placebo. The main goal is to see if AK139 reduce…

This study tests whether a new way of aiming radiation beams (non-coplanar) can reduce side effects like dry mouth and swallowing problems in people with head and neck cancer. About 70 adults with cancer of the mouth or throat will be randomly assigned to standard or new radiatio…

This study tests whether adding insulin to a platelet-rich plasma (PRP) treatment helps adults who lost their sense of smell after an infection. Twenty participants will be randomly assigned to receive either PRP alone or PRP plus insulin. Their ability to smell will be measured …

This study tests whether adding steroid nasal drops to standard smell training can improve smell function in people who lost their sense of smell after an infection (like a cold or COVID-19). 100 adults with impaired smell will receive either steroid drops plus training or placeb…

This study tests whether the drug aprepitant can reduce nausea and vomiting after ear surgery. About 100 adults having middle ear procedures will be randomly assigned to receive the drug or a placebo. The goal is to see if it improves recovery comfort.

This study compares two ways to insert a cochlear implant: using a robotic device or the standard manual method. Researchers want to see which approach leads to better hearing one year after surgery. The study will enroll 32 adults with hearing loss, randomly assigning them to on…

This study tests whether rinsing with hydrogen water can reduce mouth inflammation and pain in people recovering from oral cancer surgery that used a free flap reconstruction. Thirty-six participants will use hydrogen water or plain water for oral care over 7 days. Researchers wi…

This study compares two ways to treat moderate to severe allergic rhinitis: using a nasal steroid spray plus an antihistamine nasal spray versus the same steroid spray plus an antihistamine pill. Fifty people aged 12 to 75 will be randomly assigned to one of the two treatments fo…

This study tests whether a nerve block (injecting numbing medicine near the cheekbone) can control pain after tonsillectomy in children aged 3-9, reducing the need for opioids. Sixty kids having tonsil surgery for sleep apnea will be randomly assigned to get either the nerve bloc…

This study compares a nerve block (injecting numbing medicine near the ear) to standard painkillers (fentanyl and ketorolac) for children aged 6 months to 6 years having ear tube surgery. The goal is to see if the nerve block works just as well for pain control, with fewer side e…

This study tests if a nebulized steroid (budesonide) delivered via the NasoNeb device is safe and effective for chronic rhinosinusitis. 50 adults with the condition will be randomly assigned to receive either nebulized budesonide or a standard steroid lavage. The main goal is to …

This study tests whether giving extra booster shots of allergy medicine directly into the tonsils can better control hay fever symptoms. About 276 adults with allergic rhinitis will receive either the standard three doses or additional boosters. Researchers will track symptom rel…

This study tests whether propofol or lidocaine, given right after surgery, can reduce agitation when children wake up from tonsillectomy. Eighty-two children aged 4 to 7 will be randomly assigned to receive one of the two drugs. The goal is to find a safer, more comfortable recov…

This study looks at how well a saltwater (saline) nasal spray works and how safe it is for infants and toddlers aged 3 months to 4 years with stuffy noses from colds, flu, or allergies. About 83 children will use the spray for up to 14 days, and parents will report symptom change…

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This study tests if Acoustic Resonance Therapy (ART) can relieve symptoms of Empty Nose Syndrome (ENS), a condition where past nose surgery leaves patients feeling blocked despite open airways. ART uses sound vibrations to clear mucus and reduce inflammation. About 40 adults with…

This study tests whether adding magnesium sulfate or lidocaine to a standard sedative (dexmedetomidine) better prevents coughing after functional endoscopic sinus surgery. Coughing after this surgery can cause bleeding and slow recovery. About 102 adults will be randomly assigned…

This study tests an injection called GR1802, given alongside usual allergy treatments, to see if it can better control symptoms like sneezing, runny nose, and itchy eyes in people with seasonal allergic rhinitis (hay fever). About 144 adults who have had poor symptom control with…

This study tests whether a natural nasal spray (Puressentiel Allergy Protection) can reduce symptoms of dust mite allergies. Twenty adults with dust mite allergic rhinitis will receive either the spray or a saline placebo before a nasal allergen challenge. Researchers will measur…

This small Phase 2 trial tests whether a single dose of zafirlukast, an asthma drug, can prevent nasal symptoms caused by cat dander. Twelve adults with cat allergies will receive either the drug or a placebo before being exposed to cat dander in a controlled setting. Their sympt…

Researchers at Queen's University are testing a method to safely trigger eye allergies in a research setting. They will apply timothy grass extract to the eyes of allergic and non-allergic volunteers, then measure symptoms and collect tear and nasal fluid samples. The goal is to …

This study follows about 1,000 adolescents and adults in China with severe chronic rhinosinusitis with nasal polyps, a condition causing nasal blockage, loss of smell, and poor quality of life. Over 36 months, researchers will track the treatments patients actually receive, such …

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks back at the medical records of 200 people who received a SONATA 2 cochlear implant. The goal is to understand how well the implant works over time in real-world settings, including speech recognition in quiet and noisy environments. Researchers will also analyze …

This study aims to find biological markers in saliva, mouth rinse, blood, or tissue that could help identify and predict the course of oral cancer, gum disease, and tooth decay. Researchers will collect health information and samples from 4,000 adults with these conditions and he…

This study looks at whether a rare, jagged shape of a small bone inside the nose (the inferior turbinate) is linked to thickening of the lining in the nearby maxillary sinus. Researchers will review existing cone-beam CT scans from adults aged 18-75 to compare sinus and nasal fea…

This study tests whether an artificial intelligence model can estimate a person's risk of developing Parkinson's disease. Participants aged 50 and older who have certain early warning signs—like REM sleep behavior disorder, drops in blood pressure upon standing, or reduced sense …

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study aims to identify and describe people with allergic conjunctivitis (eye allergies) caused by cats or birch tree pollen, with or without accompanying allergic rhinitis (hay fever). Researchers will collect information and perform allergy tests to see who qualifies for fu…

This study investigates whether substances in saliva, specifically interleukin-6 levels and certain gene variations, can indicate whether oral cancer has spread to lymph nodes in the neck. Researchers will collect saliva samples from adults with oral squamous cell carcinoma befor…

This trial tests whether a responsive web-based training system helps medical students and junior doctors learn to interpret sinus CT scans more accurately than traditional text-and-image materials. Thirty-six participants with no prior specialized training will be randomly assig…

This study compares two ways to rebuild the nose after partial or total loss: surgery using skin flaps, or a custom-made prosthetic nose (epithesis). Researchers will ask people who had either treatment at least one year ago to fill out a questionnaire about how their nose looks …

This study will measure balance, coordination, and reaction time in 41 adults aged 18-40 who experience motion sickness. Participants will complete a series of physical tests and a controlled motion sickness provocation session. The goal is to see how these sensorimotor skills re…

This study follows 100 adults diagnosed with skull base osteomyelitis, a rare and serious bone infection near the ear and skull base. Researchers will track how often the infection returns or leads to death within 12 months. The goal is to gather real-world data to help standardi…

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study aims to understand the different cell types in oral cancer and pre-cancerous mouth lesions. Researchers will analyze tissue and blood samples from 150 participants to map gene activity and cell interactions. They will also test whether a simple brush sample can replace…

This study will test whether a special ultrasound score, called OTUS, can accurately track disease activity in people with Takayasu arteritis, a rare condition that causes inflammation of the large arteries. Researchers will follow 100 patients with active disease, performing ult…

This study looks at chronic sinusitis with nasal polyps, a condition causing long-term nasal congestion and breathing problems. Researchers will measure inflammation markers and examine nasal tissue from 10 adults using a steroid spray (budesonide). The goal is to better understa…

This study looks at whether measuring the thickness (viscosity) of nasal mucus can help doctors better understand the type of inflammation in people with chronic sinusitis and nasal polyps. Researchers will compare mucus from 60 patients having sinus surgery—some with polyps and …

This study tests whether injecting two dyes around the tumor and into cancerous lymph nodes can help surgeons spot hidden cancer spread in head and neck cancer. Twenty adults with oral cavity or head and neck skin cancer will receive the dyes before surgery. The goal is to see if…

This study will use MRI scans to see how well the palate and throat muscles work after a special surgery for cleft palate repair. The surgery uses a piece of cheek muscle to close the gap and aims to improve speech. Ten people who have not had early treatment will get the surgery…

This study will interview 30 children aged 6-17 who are undergoing chemotherapy for cancer, along with their parents, to understand how they deal with changes in taste, smell, and food texture. The goal is to learn what coping strategies families use at home and in the hospital t…

This study looks at how often people develop speech or swallowing problems after a jaw-advancement surgery for obstructive sleep apnea. Researchers will measure nasality, speech, and swallowing in 28 adults before and after surgery at five different times. The goal is to better u…

This study looks at 10 adults over 50 with hearing loss and one weak balance ear. It compares implanting the device in the weak-balance ear versus the good-balance ear. The goal is to see if choosing the weaker side helps reduce dizziness after surgery.

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study looks at patients with a type of throat cancer (nasopharyngeal carcinoma) whose tumors did not shrink after two rounds of chemotherapy. It compares two different next steps: switching to a different chemotherapy combination before radiation, or going straight to radiat…

This study will test a new way to score CT scans to see how well it measures smell loss in people with central compartment atopic disease (CCAD), a type of nasal allergy. Researchers will compare the new scoring system to the traditional one in 120 participants. The goal is to im…

This study looks for biological markers in people with nasopharyngeal carcinoma to help predict how the disease will progress and how well treatments might work. Researchers will analyze tissue samples from 60 newly diagnosed patients who have not had their cancer spread. The goa…

This study uses artificial intelligence to understand how air pollution and climate change impact respiratory diseases like allergic rhinitis and asthma. Researchers will gather health data from about 1,900 patients across Europe and analyze it with AI tools to find better ways t…

This study aims to better predict how head and neck cancer responds to chemoradiotherapy. Researchers will use MRI, PET/CT scans, and blood/tumor DNA tests from 152 patients to build a combined prediction model. The goal is to identify which patients have a complete response with…

This study looks at whether helping people who have trouble smelling can improve their health and happiness. Many people don't realize their sense of smell is fading, which can affect mood, nutrition, and even safety. Researchers will give smell tests and coping advice to 1000 ad…

This study uses CT scans to see how a deviated nasal septum (a crooked wall inside the nose) affects the size of the maxillary sinuses and the chance of developing sinusitis. Researchers will compare the deviated side to the normal side in 120 adults. The goal is to better unders…

This study will look at tissue samples from 600 people with nasopharyngeal carcinoma to understand how the tumor's immune environment changes over time. The goal is to find markers that predict how well immunotherapy will work and to identify new treatment targets. Participants m…