New study aims to find best surgery for babies born with blocked nose
NCT ID NCT07173023
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two surgical techniques for infants born with choanal atresia, a condition where the nasal passages are blocked. Thirty infants up to 6 years old will receive either a puncture with mitomycin C or a flap technique. The goal is to see which method keeps the airway open longer and reduces the need for repeat surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mitomycin C
- What this could lead to
- If successful, this could identify a better surgical approach to keep nasal passages open longer in infants with choanal atresia.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply to all patients. The surgery carries standard risks of anesthesia and infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2025
An estimate. Start dates often move.
- Expected to finish
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Sep 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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0 to 72 months
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 0-72 months at enrollment. * Diagnosis of congenital choanal atresia (unilateral or bilateral) confirmed by nasal endoscopy and CT imaging. * Patients presenting with clinical symptoms (e.g., nasal obstruction, respiratory distress, feeding difficulties) or requiring surgical intervention. * Guardians willing to provide informed consent and comply with follow-up. Exclusion Criteria: * Acquired (non-congenital) choanal atresia. * Previous surgical intervention for choanal atresia. * Significant comorbidities contraindicating surgery (e.g., unstable cardiopulmonary status). * Incomplete medical records or anticipated inability to complete follow-up.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.