New beam angle may spare cancer patients from dry mouth and swallowing woes

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Patient diagnosed with non-operated, non-metastatic squamous cell carcinoma of the oral cavity or oropharynx, histologically confirmed, with p16 status determined by immunohistochemistry, and indicated for curative bilateral radiotherapy, with or without concomitant chemotherapy * Patient scheduled to receive standard photobiomodulation treatment protocol during radiotherapy * ECOG performance status ≤ 2 * Presence of xerostomia \< 1 according to CTCAE v6.0 at pre-inclusion * Patient able to provide informed consent and capable of complying with study follow-up, including visits for completion of quality of life questionnaires and salivary tests * Patient affiliated with a social security system or equivalent Inclusion Criteria (RECOARD 2.0 recommendations) to be confirmed with the information provided by the simulation/plan treatment CT scan : \- Exceedance of a dose constraint for at least one Organ at Risk (OAR) as defined below with a coplanar beam arrangement : * The average dose delivered to at least one parotid gland must be greater than 26 Grays, and/or =\> 65% of the oral cavity receives a dose greater than 30 Grays, and/or * The average dose delivered to at least one submandibular gland must be greater than 32 Grays, and/or * The average dose delivered to the larynx exceeds 43.5 Grays. Exclusion Criteria: * Other head and neck locations than the oral cavity and oropharynx, and/or a surgically treated UADT cancer, and/or radiotherapy treatment already started. * Histologies other than squamous cell carcinoma * Tumors requiring only unilateral irradiation. * Non-curative irradiation and/or metastatic patient * Double tumor localization * Previous history of head and neck radiotherapy. * Inability to comply with study follow-up visits and medical assessments due to geographical, social, or psychological reasons. * Individuals under legal custody or guardianship (including curatorship). * Pregnant or breastfeeding women (pregnancy test required at inclusion).